Peptide and Protein Drug Delivery (Advances in Parenteral Science, No 4)

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This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai

Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Second Edition

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Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Second Edition
Ajay K. Banga
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 0849316308

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Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up-to-date, relevant information on protein formulation and/or delivery systems and the need for a new edition is self-evident. This second edition continues the tradition of providing a ready-to-use reference of accurate information, tables, and illustrations. The book begins with the basics of the origin of recombinant proteins, explores structural and analytical aspects, and moves on to discuss the stability of proteins and peptides. Against this background, the author addresses preformulation and formulation considerations and provides detailed information on important topics such as lyophilization. He goes on to discuss various delivery systems, including controlled release delivery systems and products currently on the market. The book also contains newly added regulatory information and thoroughly investigates therapeutic drugs made from proteins as well as protein-based vaccines. A new chapter on recombinant protein subunit vaccines and their delivery systems has been added. The work of a single author, the book provides complex information in a simple, elegant, and cohesive style. The author minimizes overlap between coverage and includes extensive cross-referencing that links related topics. Completely revised and updated, packed with cutting-edge information, the second edition once again fills the need for a reference that pulls all the relevant information together into one resource.

Inhalation Delivery of Therapeutic Peptides and Proteins (Lung Biology in Health and Disease)

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Inhalation Delivery of Therapeutic Peptides and Proteins (Lung Biology in Health and Disease)

Manufacturer: Informa Healthcare
ProductGroup: Book
Binding: Hardcover

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ASIN: 0824797809

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This exhaustive reference-the first book of its kind to describe in detail the functionality of the human respiratory tract and its impact on both local and systemic delivery of biotherapeutic and macromolecular drug systems-offers comprehensive analyses of peptide and protein drug delivery through the lung. Summarizes over 130 patents granted worldwide on alternative systems for pulmonary delivery of therapeutic drugs-especially peptides and proteins! Examining macromolecular drug delivery as an efficient, patient-friendly, and cost-effective method of treatment, Inhalation Delivery of Therapeutic Peptides and Proteins discusses · airway physiology and biomechanics · the pharmaceutical concerns associated with the respiratory tract as a viable port of drug entry to the body · key peptide drugs under development and in use to treat local lung disease, including cyclosporines, interferons, antitrypsins, protease inhibitors, and deoxyribonucleases · the systemic delivery of peptide and protein drugs using fine-particle technology · gene therapy employing gene delivery through the airways · new developments in pulmonary delivery technologies emphasizing inhaled peptide and protein drugs · guidelines for the successful introduction of peptide inhalation aerosol products into the marketplace · and much more!

Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids

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Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids

Manufacturer: CRC
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ASIN: 0849323347

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Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present biological barriers to extravasation and cellular uptake of proteins and nucleic acids. Combining an introduction to biomaterial delivery with the latest developments in the field, this is a valuable reference for both the novice student and the practicing scientist on delivery of biomaterials, on biomedical polymers, and on polymer therapeutics. Understanding these core fundamentals is critical to moving on to more advanced study.

Delivery of Protein and Peptide Drugs in Cancer

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Delivery of Protein and Peptide Drugs in Cancer
Vladimir P. Torchilin
Manufacturer: Imperial College Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1860946275

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Written by leading scientists in the field of delivery of protein and peptide drugs to tumors for cancer therapy, this important book provides a broad introduction to the field, with discussion by key experts on the physiological barriers for protein and peptide drugs in tumors, and the different approaches to stabilization of these drugs in biological surroundings, as well as their enhanced delivery to tumors and inside cancer cells.

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This volume reviews protein stability and the analytical and biophysical characterization of proteins. It emphasizes drug delivery approaches, especially local delivery through the skin. Including both academic and industrial perspectives from such companies as Genentech, Amgen, and Merck, the book also discusses novel drug delivery polymers and the development of pharmaceutical protein formulations.

Trends and Future Perspectives in Peptide and Protein Drug Delivery (Drug Targeting and Delivery, Vol. 4)

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Trends and Future Perspectives in Peptide and Protein Drug Delivery (Drug Targeting and Delivery, Vol. 4)
Vincent Lee
Manufacturer: CRC
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Binding: Hardcover

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Peptide and protein drug delivery research has been moving at a brisk pace for over 10 years. Trends and Future Perspectives in Peptide and Protein Drug Delivery is a collection of snapshots of the major past and future developments in this exciting field as seen by over 20 invited speakers at a three-day conference on protein drug delivery held on September 2-4, 1993, in Kyoto, Japan. The wide-ranging topics covered included polymeric delivery systems for protein drugs, means of enhancement of protein drug transport, protein modification for improved pharmacokinetic/pharmacodynamic properties, targeting of peptide and protein drugs, and delivery of oligonucleotides and genes.

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Sobolev Spaces presents an introduction to the theory of Sobolev Spaces and other related spaces of function, also to the imbedding characteristics of these spaces. This theory is widely used in pure and Applied Mathematics and in the Physical Sciences.

This second edition of Adam's 'classic' reference text contains many additions and much modernizing and refining of material. The basic premise of the book remains unchanged: Sobolev Spaces is intended to provide a solid foundation in these spaces for graduate students and researchers alike.

* Self-contained and accessible for readers in other disciplines.
* Written at elementary level making it accessible to graduate students.

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The creation of an ethos.......2005-09-18

A comprehensive exposition of the Sobolev creation: the ethos of the solutions for differential equations. Ethos means dwelling, but much more than abode it means a way of being. The Sobolev spaces are the whole being of the solutions, the way they are. The way they look like.

Adams and Fournier present that ethos with detail. All important and essential properties are studied rigorously and exhaustively. Those dwellings have the convenient property of being complete. This means that they are Euclidean extensions without gaps; they are continuous extensions, no holes, no hiatus. One cannot gain everything, there is always something missing. The lack of the ethos created by Sobolev is huge: the metric limitation does not guarantee scarceness of extension. This is a major problem we have to deal with. A new concept of proximity has to be invented. Also, it is very important to enable reification since a solution living in the Sobolev ethos has to be a vintage solution.

The book is indispensable for graduate student and researcher that wish to struggle along the road of the non-linear differential equations.

An invaluable resource.......2003-08-19

As a PhD student in mathematics focusing on theoretical PDE, I find this monograph to be one of the most useful in my collect. The book is self contained and very easy to read, requiring only a background in real analysis at the beginning graduate/senior undergrad level. This text covers a wide range of topics from the basics of topological vector spaces, all the way through interpolation methods and Besov spaces, but maintains a deep enough level so that most researchers will find this book to be very useful as a reference for the subject. In particular, I really like the completeness by which the imbedding theorems in the book are stated and proved. In addition to the content, the book is also beautifully bound and is printed on very high quality paper.

very interesting.......2003-07-18

A very interesting textbook for people interested in functional analysis. It provides a great introduction for beginners but also clear and rigorous demonstrations of more technical points.

highly recommended.......2003-07-14

I highly recommend this book. It is a valuable reference and a great introduction to sobolev spaces for people interested in functional analysis.

Sobolev Spaces, Second Edition (Pure and Applied Mathematics, Volume 140) (Pure and Applied Mathematics)

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Sobolev Spaces, Second Edition (Pure and Applied Mathematics, Volume 140) (Pure and Applied Mathematics)
Robert A. Adams
Manufacturer: Academic Press
ProductGroup: Book
Binding: Paperback
ASIN: B000OHG6A2

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James McPherson has emerged as one of America's finest historians. Battle Cry of Freedom, his Pulitzer Prize-winning account of the Civil War, was a national bestseller that Hugh Brogan, in The New York Times Book Review, called "history writing of the highest order." In that volume, McPherson gathered in the broad sweep of events, the political, social, and cultural forces at work during the Civil War era. Now, in Abraham Lincoln and the Second American Revolution, he offers a series of thoughtful and engaging essays on aspects of Lincoln and the war that have rarely been discussed in depth. McPherson again displays his keen insight and sterling prose as he examines several critical themes in American history. He looks closely at the President's role as Commander-in-Chief of the Union forces, showing how Lincoln forged a national military strategy for victory. He explores the importance of Lincoln's great rhetorical skills, uncovering how--through parables and figurative language--he was uniquely able to communicate both the purpose of the war and a new meaning of liberty to the people of the North. In another section, McPherson examines the Civil War as a Second American Revolution, describing how the Republican Congress elected in 1860 passed an astonishing blitz of new laws (rivaling the first hundred days of the New Deal), and how the war not only destroyed the social structure of the old South, but radically altered the balance of power in America, ending 70 years of Southern power in the national government. The Civil War was the single most transforming and defining experience in American history, and Abraham Lincoln remains the most important figure in the pantheon of our mythology. These graceful essays, written by one of America's leading historians, offer fresh and unusual perspectives on both.

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McPherson Excels with A. Lincoln Again.......2006-06-30

James McPherson (Battle Cry of Freedom) is the preeminent Civil War author and scholar of our time. The Princeton University professor provides fresh insight into A. Lincoln in these seven essays.

McPherson demonstrates conclusively that the Civil War was indeed the Second American Revolution - it abolished slavery and smashed the political, economic, and social status quo. Before the War, southerners dominated American politics - after the war it was decades before a son of the south could be elected President. The absence of the south from the national legislature during the war allowed the passage of the great progressive and modernizing legislation; the Homestead Act, enabled a continental railroad, and land-grant colleges. After the war, blacks made great (if far from complete) progress in education, politics, and economics.

Unfortunately, the reactionary forces led a counter-revolution that attempted to turn back the massive changes in society with much success. That counter-revolution eventually yielded to a Second Reconstruction in the mid-20th century.

McPherson repeatedly returns to Lincoln's political evolution as the War changed from a limited war for limited ends to a total war for revolutionary ends. In the end Lincoln insisted on unconditional surrender.

I particularly enjoyed the essays entitled 'How Lincoln Won the War with Metaphors', which contrasts the communication abilities of Lincoln and Jefferson Davis, and 'The Hedgehog and the Foxes', in which McPherson favors us with a description of Lincoln as the single-minded hedgehog outlasting the multifarious foxes such as Horace Greeley and William Seward.

My only small quibble is that similar points are made using the same quotes in multiple essays (perhaps unavoidable in a collection of previously published essays), but the quotes are so evocative of Lincoln's thinking that the repetition is not only forgiven, but enjoyed.

Highly recommended for anyone interested in US history, Lincoln, or the Civil War era.

CATACLYSMIC MIND.......2005-11-24

ABRAHAM LINCOLN AND THE SECOND AMERICAN REVOLUTION by James M. McPherson is a thin juicy volume. You feel energized as you read and absorb its deep insights. Each of six essays shows that it was Lincoln's reality anchored character and powerful intellect that transformed the United States to the country it is today. One essay shows how Lincoln's use of metaphor, culled from Aesop's Fables, the works of Shakespeare, and the Bible made him a consummate communicator. His metaphors resonated to the deepest layers of mind of the average American in way that instilled motivation and purpose to a war that seemed impossible to manage or win. Compared to Jefferson Davis who was so highly educated and abstract but was unable to connect with ordinary folk. But it is McPherson who too is able to convey to us this president's great powers with his own metaphors i.e. "barnyard philosophy," and his essay, "The hedgehog and the fox," which compares and contrasts Lincoln's abilities with the "smartest contemporaries." ABRAHAM LINCOLN AND THE SECOND AMERICAN REVOLUTION is a great distillate of the voluminous Civil War Literature. You must have it for your library.

How Lincoln changed the United States..........2004-06-08

This thin book which contains series of essays on how Abraham Lincoln revolutionized our nation during one of the most important periods of our nation proves to be well written and amazingly easy to understand. James McPherson writes clearly how the American Civil War was truly a revolutionary moment in our nation's history and how Lincoln took steps to ensure these changes. How we lived, our political/racial/social norms that are part of our society today took form during the Civil War. Even the way we waged war, have it roots in the Civil War, all have Lincoln's fingerprints all over it.

The book proves to be easy to follow and read. But in its simple prose, lies amazing insights and perception of Lincoln's influence during the war and his abilities to effect changes in our nation. I would say that this book is a "must read" for anyone interested in American history.

How Lincoln Transformed America.......2003-09-30

Books on Abraham Lincoln and on the Civil War abound, but few books explore their significance with the eloquence and erudition of Professor McPherson's "Abraham Lincoln and the Second American Revolution." This book is a compilation of seven essays which discuss the transformations the Civil War brought to the character of the United States and the indespensable role Lincoln played in bringing these transformations about.

In these essays, Professor McPherson explains that the changes the Civil War brought about can be summarized in two words: Nation and Liberty. First, The Civil War transformed a Union of States into a single Nation. This change is exemplified in Lincoln's Gettysburg Address. As Professor McPherson points out in the preface to his essays, in the Gettysburg Address Lincoln spoke of the American "nation" rather than of a "union" in order "to invoke a new birth of American Freedom and nationhood." (p. vii)

Second, the change of America from a union of states to a nation was accompanied by a change in the concept of liberty on which the nation was founded. In a word, this change involved emancipation, the abolition of slavery, and the application to all people of the principle articulated in the Declaration of Independence that "all men are created equal". In several essays, Professor McPherson uses the work of the political philosopher Isaiah Berlin to develop a distinction between negative and positive liberty. Before the Civil War, liberty was understood primarily in a negative way whcih involved individual freedom from government regulation and freedome from interference with private property. With the Civil War, the concept of liberty changed to allow the Federal government to assume a positive role in promoting human freedom and human good. The most striking example, of course, is the abolition of slavery. But the concept of the government's role in creating a positive concept of liberty has continued.

Professor McPherson's essays show how Lincoln unified the ideals of Nationhood and Liberty as the Civil War progressed and thus effected a revolution in the basic nature of the United States. The essays explore these basic themes masterfully as Professor McPherson discusses Lincoln's political skills, his insistence on the unconditional surrender of the South, the development of Lincoln's ideas on emancipation, the significance to the second American Revolution of Lincoln's eloquence as a speaker and a writer, and much else.

Professor McPherson also discusses the Reconstruction period in a thoughtful way. He takes issue, in part with modern revisionsists who claim that the Civil War failed in its basic aims by the backtracking from Reconstruction and the reinstitution of Jim Crow that occurred following 1876. A "second reconstruction" proved necessary in the mid-20th Century to realize fully the aims of the first. But this does not derogate, Professor McPherson argues, the significance of the Revolution that was wrought by Lincoln and the Civil War.

This book will help the reader to think about Abraham Lincoln and to understand why the Civil War remains the pivotal event in our Nation's history.

Great Analysis, Poor Editing.......2003-03-19

James McPherson is not only the preeminent Historian of the US Civil War, but one of the greatest historians working today. He offers razor sharp analysis of complicated issues, with fair consideration of all points of view. Best of all, McPherson does all that in clear, concise and at times poetic language, that is remarkably easy to read.

'Abraham Lincoln and the Second American Revolution' enjoys all the benefits of McPherson's considerable scholarship. Its problems are almost exclusively editorial.

This thin volume (152 pages of text; 20 more pages for notes, bibliography and an index) contains seven essays about the two themes in the title - The US Civil war seen as the second American Revolution, and Abraham Lincoln's role in it.

The first essay argues convincingly that the Civil War did radically change the Unites States. From a Slaveholding Republic, it became a free one. Politically, the center of gravity moved from the South to the north. Economically, the Industrial revolution, earlier contained in New England, spread out and defeated the plantation economy. In the South, the prevailing order was weakened, although not surmounted, and the situation of Blacks improved considerably, although equality was still very far. The theme McPherson is most interested in, however, is the change from a philosophy of negative liberty - freedom from government oppression - to one of positive liberty - the right for protection - guaranteed by the Federal government.

The second essay discusses Lincoln's role as the leader of the revolution. Lincoln, McPherson argues, was a pragmatic revolutionary. The revolution, which he brought on America, was caused by Lincoln's accurate assessment of necessities, not by a strong ideological tie to the revolution. Lincoln was no Lenin - he held sternly to the one principle of democracy, and the second American Revolution happened as a by-product of defending this principle.

In the third essay, 'Lincoln and Liberty', McPherson discusses how Lincoln's struggle for positive liberty was seen as despotic by those holding the principles of negative liberty. The Republicans wanted to restrict and ultimately destroy the rights of Southerners to hold slaves - and to enforce these restrictions by government action, if that was what it took.

Lincoln's role as supreme military commander is a neglected issue in Civil War historiography, claims McPherson, and he sets out to remedy that in the following essay. Lincoln's most important contribution, he concludes, was his unyielding hold on the doctrine of Unconditional Surrender. This issue also returns in Essay number 6, which compares Lincoln to Northerners who were not nearly as clear about the goal of fighting as he was.

Lincoln's rhetoric and the use of metaphors is the subject of the fifth essay. In an interesting comparison with Jefferson Davis, McPherson concludes that Lincoln's usage of metaphors in writing and speaking made him a superb communicator, which Davis wasn't. Thus, McPherson agrees with David Potter that had Lincoln been the leader of the South in the war, the confederacy might have maintained its independence.

One weakness of the collection is the lack of coherence in topics. The illuminating comparison between Jefferson Davis and Abraham Lincoln in this essay, for example, is sadly missing from other chapters. Take War Leadership -Lincoln's grasp of the northern grand strategy made him replace popular generals who nonetheless could not follow his concept of total war. Jeff Davis on the other hand, despite his superior military background (as a war hero and a West-Point graduate), never articulated war aims as Lincoln did, and the Confederate war policy was constructed de facto by the decision of its irregularly brilliant generals. Lincoln would have made much better use of Robert E. Lee than Davis did.

The absence of such themes concurring through the book weakens the narrative, and it remains more an anthology than a focused monograph. Another such problem is the repetition between the essays. The final essay repeats almost all of the discussion about Isaiah Berlin's concepts of positive and negative liberty, before launching into the new theme. That theme, the turning away from positive liberty back to negative liberty during reconstruction, is fascinating. During reconstruction, Republicans had to constantly use the military in order to enforce equality for blacks on the unwilling Southrons. The disillusionment from Reconstruction and the resurrected fear from governmental tyranny left the racist policies of the South for another century, when Martin Luther King finished that job that Abraham Lincoln has began.

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Abraham Lincoln and the Second American Revolution
James M. Mcpherson
Manufacturer: Easton Press
ProductGroup: Book
Binding: Leather Bound
ASIN: B000IOW8EO

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Abraham Lincoln and the Second American Revolution
James McPherson
Manufacturer: Oxford University Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000K00QH2

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Abraham Lincoln and the Second American Revolution
James M. McPherson
Manufacturer: Oxford
ProductGroup: Book
Binding: Hardcover
ASIN: B000O61HMU

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Abraham Lincoln and the Second American Revolution
James M. mcPherson
Manufacturer: Oxford University
ProductGroup: Book
Binding: Paperback
ASIN: B000GX3YAE

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By the Pulitzer Prize-winning author and Civil War expert, emphasizing how thoroughly Lincoln changed the U.S.

ABRAHAM LINCOLN AND THE SECOND AMERICAN REVOLUTION

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ABRAHAM LINCOLN AND THE SECOND AMERICAN REVOLUTION
James M. McPherson
Manufacturer: OUP
ProductGroup: Book
Binding: Paperback
ASIN: B000NST36G

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Abraham Lincoln and the Second American Revolution
James M. Mc Pherson
Manufacturer: Easton Press
ProductGroup: Book
Binding: Leather Bound
ASIN: B000TBNQN8

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Abraham Lincoln and the Second American Revolution
James M. McPherson
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback
ASIN: B000OKG8RK

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Abraham Lincoln and the Second American Revolution
James M. McPherson
Manufacturer: Oxford Univ Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000OLTCTU

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