Annual Reports in Medicinal Chemistry, Volume 41 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market.

* Critical reviews of the previous year's literature in many topics of interest to medicinal chemists
* Highlights major developments in medicinal chemistry
* Includes a comprehensive set of cumulative indices to easily locate topics in all published volumes

Annual Reports in Medicinal Chemistry, Volume 38 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry, Volume 38 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry, Volume 41 (Annual Reports in Medicinal Chemistry)

ASIN: 0120405385

Book Description

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Sections I-IV are disease-orientated and generally report on specific medicinal agents.

Sections V-VI continue to emphasize important topics in medicinal chemistry, biology and drug design.

In addition to the chapter reviews, a comprehensive set of indices has been included to enable the reader to easily locate topics in Volumes 1-38 of this series.

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Annual Reports in Medicinal Chemistry, 1965 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry, 1965 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry, 1966 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry, 1966 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry, 1967 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry, 1967 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry, 1968 (Annual Reports in Medicinal Chemistry)

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Annual Reports in Medicinal Chemistry, 1968 (Annual Reports in Medicinal Chemistry)

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An Account of the Necessity for and Probable Origin of the Development of Sex. And of the Development of the Conscious State In the Evolution of the Organic World, with a Preliminary Statement of Fundamental Cosmical Principles.

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"Is it any wonder I had to go to Africa?".......2007-07-13

What do Saul Bellow, Joni Mitchell, Sonic Youth, Counting Crows, and the X-Files all have in common? In his novel, Henderson the Rain King (1959), Bellow (1915-2005) blends philosophy and comic adventure to tell the story of 55-year-old Eugene Henderson who, despite his wealth, is unhappy with "the disorderly rush" of his life. "All is grief," he says, "my parents, my wives, my girls, my children, my farm, my animals, my habits, my money, my music lessons, my drunkeness, my prejudices, my brutality, my teeth, my face, my soul" (p. 3). He asks, "is it any wonder I had to go to Africa?" In an attempt to escape his troubled existence and the voice in his heart saying, "I want, I want, I want," Henderson sets off for Africa. Upon his arrival, he hires a native guide (Romilayu), who leads him to the village of the Arnewi, where the village water supply is plagued by frogs. After traveling to another village (Wariri), the natives mistake Henderson for the Wariri Rain King, and he becomes friends with the village's western-educated king (King Dahfu), who teaches him how to fill his spiritual void. Transformed from The King of Pain to The King of Rain by his African experience, Henderson returns to America claiming to see life from both sides now, to "dream both upward and downward." "We are the first generation to see the clouds from both sides," he says. "What a privilege! First people dreamed upward. Now they dream both upward and downward. This is bound to change something, somewhere" (p. 280). Bellow's novel was not only the inspiration for Joni Mitchell's 1967 song, "Both Sides Now," it was also the inspiration for Sonic Youth's song, "Rain King," (on the Daydream Nation cd), for the Counting Crows' song, "Rain King," (on the August and Everything After cd), and for the X-Files' episode, "Rain King," in which agents Mulder and Scully investigate a man who claims to control the weather.

Henderson's mid-life search for meaning is a prominent theme in Bellow's novels. It resurfaces, for instance, in his Pulitzer-Prize winning novel, Humboldt's Gift (Penguin Classics) (1975), where Bellow's middle-aged protagonist, Charlie Citrine, observes "how sad about all this human nonsense which keeps us from the large truth." Among Bellow's novels, critics consider Henderson the Rain King either his best or worst work, but Bellow reportedly considered it his personal favorite. It is ranks at 21 on Modern Library's list of The 100 Best Novels.

G. Merritt

I didn't like it..........2007-04-01

The blurbs on the book cover promised laughs. There weren't any. This book made the MLA 100. I'm mystified why. It is competently written, I admit, but Henderson is an unlikable jerk, and the dialogue given him by Bellow is ridiculous. I didn't care if Henderson lived or died; I didn't care what Henderson thought; I didn't care about the book. I wanted to hurry up and finish the damned thing, already.

Absurd but engaging Africa, a great writer........2007-03-24

First of all who am I to review a Pulitzer prize winner? Anyhow, this book was very highly recommended to me by my friend, an English college professor. He knew I had lived for two years in Africa and enjoyed good writing.

The verdict: Bellow is undoubtably a great writer. This book is an unusual vehicle to showcase his talent. I had a hard time liking Henderson, the main character, too much of an ugly american but with a subtle side with some charitable nature. The Africa detailed here is too fantastic, a tribal fantasy but it is a clever way to bring the adverturesome Henderson into contact with King Dahfu. King Dahfu is the highly educated African caught between the western world and his traditional home. Some of the best writing in the book comes in the dialogue between Henderson and Dahfu as they encounter Dahfu's captured deadly lioness in the dungeon. Somehow they wage wits over man's stuggle for meaning while dodging the circling lioness. There were additional sections that had me laughing out loud at Henderson's predicaments.

There are brilliant lines in this book, lines that make you pause to savor them, scenes vividly painted and strong emotion, enough here that makes me want to read more from Bellow even if it isn't about Africa.

A LARGE MAN, A SPECIAL FRIEND AND A LION CUB.......2007-03-22

This is such an entertaining novel. Henderson is a colorful and honest narrator and his story becomes surprising real to the reader. It has been over a week since I finished Henderson the Rain King and it is still vivid in my memory. I started my Saul Bellow collection with the Adventures of Augie March and I did not find Augie to be a likeable hero. Henderson is a very flawed man, but is touching in his struggles.This book is a brilliant reminder of the powers of friendship.

Inspirational and Entertaining Story of one Man's Search for Meaning.......2006-08-06

In this book, Saul Bellow creates one of the most colorful and interesting characters in American Literature. Eugene Henderson is an eccentric millionaire restlessly struggling with a lack of purpose and an inner-voice that keeps crying out "I want, I want." In order to find meaning in his life and silence this voice inside him, he travels to the deepest reaches of the African jungle.

There, stricken with a constant fever and facing challenges including wrestling with a tribal warrior and foraging on locusts for survival, the 'unkillable' Henderson will stop at nothing to acquire this enlightenment. His adventures, which can be quite comedic at times, are rewarded by the wisdom he obtains from the tribal leaders including the highly educated and equally eccentric King Dahfu.

The result is a very inspirational and entertaining story that will stay with you for a long time.

Saul Bellow: Novels 1956-1964: Seize the Day, Henderson the Rain King, Herzog (Library of America)

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Bellow Vol.2
A beautiful edition of three powerful works by an American master
The best of Bellow in one great volume

Saul Bellow: Novels 1956-1964: Seize the Day, Henderson the Rain King, Herzog (Library of America)
Saul Bellow
Manufacturer: Library of America
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Binding: Hardcover

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ASIN: 159853002X
Release Date: 2007-01-11

Customer Reviews:

Bellow Vol.2.......2007-02-06

Another great collection of Bellow's works. Hope the Library of America comes out with the next volume sooner than a year.

A beautiful edition of three powerful works by an American master.......2007-02-06

These are three very fine, even great, novels. Of course, one doesn't simply dash through Bellow. Each page requires and rewards close reading. While Bellow has been criticized for putting some things in his novels to show off his vast erudition, I found those details interesting and that they contributed to an understanding of the characters in each story.

The first novel is also the shortest. "Seize the Day" is about a middle-aged man who has lost his way in life. Tommy Wilhem can't escape his father or his wife. He hasn't ever found a way to get a footing in life or to carve out a place of success for himself. Tommy's mother died too soon, and it seems his father is living too long. Not that we wish the old guy would die, but because he is so focused on himself that he has become a competitor to his son and does not respond as much of a father, let alone an indulgent one. The wife Wilhelm has left won't give him a divorce (this is before no-fault divorces) and is using everything at her disposal to punish Tommy. Should Tommy surrender and come home emasculated? Yes, Wilhelm has or had a girlfriend, but he doesn't even pull that off well.

Tommy is so desperate for approval that he first went to Hollywood to become the movie star a crooked agent said he could be. The central part of the story involves the investment strategies of Dr. Tamkin. Tommy hopes against reason that Tamkin can succeed and get him not only out of the financial pit he is in, but make him a success so he can finally be his own man. Well, a man of any kind. Some read the end of the story as Tommy finding a place for himself at last and that he will turn things around. I think this is a quite optimistic gloss on what the text actually says.

"Henderson the Rain King" is actually a lot of fun. While many have made the observation that Eugene Henderson's initials, the big gun, Africa, and hunting all betoken a satire of Hemingway, the writing is nothing like his. There is no doubt that Bellow is poking fun at a great many schools of then modern writing, but he is also dealing with the same kinds of themes teased out in "Seize the Day", but in comic form and drawn on a much larger canvas.

Henderson is a huge and physically imposing middle-aged man who is quite wealthy. However, he didn't earn the money, nor was he supposed to get it by inheritance. His father didn't have much use for him, but the favored son died and so the $3 million went to Eugene when dear old Dad died. Henderson was also quite unsuccessful in love, though he did have some adventures along those lines. He can never settle on anything because of the inner voice that cries out "I want, I want, I want". He is able to still the voice for a time with each new thing he tries, whether it is pig farming, playing the violin, painting, taking on a new lover, or adventuring in Africa.

It is this adventuring in Africa that provides the central adventures of the story and the title of the book. It is so much fun that I have to leave it for you to read and enjoy. It isn't all comic, though there are some serious, and some tender moments. The ending does leave the door open for hope that Henderson has found a way to quiet that voice at last. However, it is also possible to read it as another temporary respite and that Eugene will need to find another distraction to throw himself into in order to find another spot of peace.

"Herzog" is unquestionably a masterpiece. This book seems to be the fulfillment of Bellow's desire for "an American novel that might more optimistically search for the `sealed treasure' of ordinary life" [from the entry for 1960 of the chronology provided in this edition]. The actual story of the book occupies only a few days in the life of Moses Elkanah Herzog. Don't you think that name is significant? Is he Moses the lawgiver? Hardly. What about the liberator - the one drawn forth in the reed basket or the one who draws his people out of slavery from Egypt to the Promised Land? Or is Bellow using ironically? What about the contrast between the English - American Moses verses the Yiddish - Hebrew Moshe that we hear him called by his stepmother? Which is he, really? Is he both the assimilated American still rooted in his childhood Yiddish? The middle name, Elkanah, means "God created" and refers to several different Levites (priestly class) in the Bible. Might this be a reference to his being a professor? A Ph.D.? The idea that the modern priests are the professors and educated elite? Again, there would be a certain sense of irony here, because Moses has quit his job, and a great deal of the book is him rejecting and commenting on the whole range of modern thought (as it was in the early 1960s).

Herzog is worn out. And very much like Tommy Wilhelm and Eugene Henderson, he suffers from a kind of impotence of the soul. His promiscuity is actually evidence of the sickness in his soul rather than a sign of robustness. He has former wife and son he threw over for a beautiful younger model, but she threw him over and cuckolded him with his "best friend" and took the daughter they had away to Chicago. It is obvious that Herzog wants her as a kind of possession and how that beauty makes him feel about himself. But it is a story that is richly played out in this large novel. Along the way, Herzog also had a longish relationship with a Japanese woman who was devoted to him, but he threw her away, too. At the time of the novel, he is involved with a strong woman named Ramona, and one of the results of her strength, which he needs and loves, is to run away from her to visit some friends. Immediately after arriving at his friends' home, he flees them, as well.

The story is famous for his impotent letter writing to historical figures, world authorities, friends, enemies, doctors, shrinks, and many other folks. But he rarely sends any of them. He does send a telegram to Ramona towards the end of the novel.

This is an amazingly detailed work that achieves a great deal in revealing the inner life of its protagonist. It was a best seller in its day and won the national book award. It is hard for me to believe that a great many of those who bought it read it from cover to cover. Maybe I am wrong. The topics of divorce, sexual affairs, cuckoldry, and madness were much more taboo than it would soon become. Maybe it was those subjects that caught the imagination of the public. However, there is nothing sensational or erotic in this work of art. That would be left to the pulp novelists such as Jacqueline Susann and an army of others beginning a few years later.

I do want to share one contrary thought that kept coming back to me as I read these novels. To these post-this and post-post-that sophisticates for whom all belief is provincial and even childish and for whom their sexual desires and phantasies become their gods and all important self-definition. Look at the wreckage of your lives, the lost wives, husbands, and children. Look at the lack of lasting happiness. Notice the need for pharmacological assistance to fight depression. Might I suggest something? Make your family the center of your life and give up the sexual fantasies and dalliances. Keep your children close and set aside the things that detract from these foundational values. Oh, I know this sounds so hick and, worst of all, center-of-the-country values. But it really isn't that. It is a form of happiness that actually works. Maybe it doesn't make for interesting novels, plays, movies, or TV shows, but those matter nothing at all. Keep your first wife or your first husband, (after you chose each other carefully - not for narcissistic reasons) and both focus on each other and your kids. Life will actually be better, and you will need a lot less legal and chemical help. Really.

All three of these novels are quite memorable. Bellow's importance has been recognized as has the quality of his work. He was awarded the Nobel Prize for literature and was also given many other awards throughout his life. "Seize the Day" was made into a movie starring Robin Williams in 1986, but I can't find it in print anywhere. One of the things I do wonder about is having twenty-year-old college students read these works. It isn't that they can't read them, of course they can. However, it is hard for me to see how they can relate to these middle aged folks without having lived more and experienced more of the vagaries of real life.

This is a fine edition from the Library of America with a great chronology of Bellow's life and some notes on the text.

The best of Bellow in one great volume .......2007-02-04

This remarkable volume contains what are in my opinion the three best novels of Bellow. One is the remarkable short novel, 'Seize the Day' the second is his African adventure the wildly comic 'Henderson' the third , his arguably best book, 'Herzog'. Herzog is his great meditation on history and civlization as he traces five - days in the life of Moses Herzog, a former university teacher, a historian, who is struggling to survive in the wake of his divorce from his second wife. In the course of this work Herzog writes letters to the living and the dead, including the famous dead a feature which gives special life to the book. In 'Seize the Day' the upper West Side of New York is the scene of the hero, Tommy Wilhelm's loss of a hold on his own life. As he pleads for money with his successful patronizing father Dr. Adler he falls into the clutches of the charlatan- wiseman Temkin and blows his last seven- hundred dollars on a speculative venture Temkin has recommended. The pathos of this tale of money- machine- murder of the soul- is great. It is a masterpiece of concise comic description and deep insight into the human heart. The final funeral scene is a truly great one.
These novels are among the finest twentieth- century American Literature has given us.
'Library of America' has done a service by putting them together in one most attractive volume.

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Henderson the Rain King

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Henderson, the rain king; a novel

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Acclaimed Christian fiction writer Francine Rivers's (The Atonement Child) Leota's Garden uses the image of the garden as a metaphor for the cycles of life that the characters experience. While the story revolves around a number of lives, they are all connected through Leota--an 84-year-old grandmother--and her garden, which was once a place of beauty and hope but has in recent years gone to ruin. Beginning in desolation--Leota has been neglected by her self-centered daughter, whose obsession with getting her own daughter into the best college has driven them apart--the novel slowly shows the weaving together of lives in the mysterious ways of grace: a proud and narrow-minded college student ends up learning more from Leota than he'd bargained for, and the granddaughter Leota had never been allowed to know shows up looking for some answers, and even more, looking for Leota herself. A garden blooms, the novel suggests, by getting one's hands a little dirty doing the hard work of love. --Doug Thorpe

Book Description

Value priced!

Award-winning author Francine Rivers opens a world full of vibrant characters with a powerful story of hope. In this stunning novel, Francine explores the new life that love can bring to a decaying garden of broken relationships. Through the lives of 84-year-old Leota, her granddaughter, and a college student with all the answers, Francine leads readers to ponder the value of life and truth in a way that only she can.

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Customer Reviews:

awesome.......2007-07-12

I'm a big fan of Francine Rivers. Love all her books. Enjoyed this one because of the struggles the mom had with her children and the way she loved her children unconditionally, even though they didn't try to see it and find it.

Beautiful.......2007-05-31

I have come to truly love every Francine Rivers book I have read. I first read the Mark of the Lion series and was so utterly blown away that I immediately began to devour the rest of her novels. True to form, Leota's Garden is much like her other non-historical fiction: very well written, engaging storyline, and characters you care about. With Rivers' historical fiction, you always feel that she has done a tremendous amount of research. With novels like Leota's Garden, a contemporary setting, you feel like she's lived it.

It took a while for me to buy this one. I was concerned that the "topic" wouldn't feel relevant or interesting to me. Not only was I wrong, but it inspired me to expand my volunteer work to include seniors.

If you are a Rivers fan, buy it. If you are an avid reader who has not read this author, very seriously consider it, but check her other works out too. Everyone to whom I have introduced her novels has had glowing reviews.

Leota's Garden.......2007-05-30

This was a good book and it is well written. I enjoyed it very much. Francine Rivers is a great author.

A beautiful story of life..........2007-03-19

in a real way. I loved reading through the eyes of Leota. She has insights that most of us just push aside. The story opened my eyes and hope it will continue how I feel in the future. It is a book everyone should read, especially mothers and daughters! I plan on letting my oldest read it!

As good as I had hoped it would be........2007-01-10

I gave this book to a Francine Rivers fan. They loved it.

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Leota's Garden
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Francine Rivers Set (The Scarlet Thread, Leota's Garden, Redeeming Love)

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Francine Rivers
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