Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding

Customer Reviews:

A lot of information, but not-so-well explained..........2005-04-13

With an undergrad degree in chemistry and a year of graduate school (granted, without a focus solely in biochemistry), this text was often difficult for me to follow and gain much from. Though the text contained an impressive breadth of topics, this breadth came at the cost of depth. In my opinion, a textbook should more-or-less stand on its own in providing a clear understanding of a topic. All too often I didn't find this to be the case with the Fersht book. Instead, I often had to consult many of the references listed in the text to obtain sufficient understanding of topics. (Fortunately, the book includes extensive reference lists.) If looking up endless references (many old and sometimes difficult to obtain) is something you enjoy, this book is for you.--If not, forget it!

Highly recommend it.......2003-08-31

Hands down the bible of enzyme kinetics!

Anyone looking to learn more about enzyme kinetics, thermodynamics, structure, and function will find this book clear, thoughtfully written, and at the forefront in the field.

essential.......2002-05-01

If you are studying protein structure, you probably should read this book for reference.

This is solely my opinion, but I have learned new things and reinforced some old knowledge, as well. The book is well-written, and understandable, without being simplistic.

Some texts are difficult to understand, or dry, or facile. This is not one of those texts.

Biochemists Can't Miss.......2001-08-23

The book focuses on enzyme catalysis, stereochemistry of enzyme reactions, determination of rate constant, enzyme kinetics, and protein structure and folding. It would be an ideal reference for the study of protein chemistry. It can serve as the primary text for an advanced course in protein chemistry or a supplement for undergraduate biochemistry text.

Protein folding has remained one of the most intricate yet less understood process in modern biochemistry. Feersht's treatise of the subject in this book is splendid. The author overviews protein structure and diversity in the opening chapter. What I find really precious about this book is the discussion on protein engineering, forces on folding, and recombinant DNA technology in the context of protein folding.

Aside from protein chemistry, the chapter on chemical catalysis is excellent in learning more about transition state theory, general acid/base catalysis, covalent catalysis, structure-reactivity relationships, and kinetic isotope effects.

The Mother of All Enzyme Books.......2001-01-10

Man, this book rocked! I took one look at the ribbon structure of ATPase on the cover and said to myself, "Whoa dude! This is, like, phat!" Then I turned the pages and BAM! I was knee deep in protein structure! Like, any first-year biochemist knows its all about the acids, as in amino, and Fersht, he knows his peptides! Oh man, I was on cloud nine! And I've been off my meds for two months now! But you wanna know the real dope? You can't say diddly about function unless you know structure, and that Alan, as in Fersht, dude! Like, he starts you off simple, like, you know, with the "building blocks," like we're a bunch of two-year-olds, and you string 'em together and get all that higher-order structure and stuff, and slowly, ever so slowly, like a mental itch that invades your consciousness and becomes screaming voices telling you to AHHHHHHHHH! So many domains! Too many functional units! No, no, nooooooo! Schiff base? Shift Bass! Ah HA HA HA HA! What do all those K's mean!?! Take me home! Please...

Protein Purification: From Molecular Mechanisms to Large-Scale Processes (Acs Symposium Series)

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Protein Purification: From Molecular Mechanisms to Large-Scale Processes (Acs Symposium Series)

Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover

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Book Description

This practical volume gives real-life examples of how separation techniques are used in industry with recombinant proteins and emphasizes which techniques might be more useful than others. An introductory chapter ties together the various topics and associates the methods used with examples of large-scale methodologies. The emphasis of the volume is on how series can be applied to developing strategies and appropriate approaches for difficult protein separation problems. This valuable book provides an update on some of the existing technology used in industry and presents separation examples of several commercially important and recently developed proteins.

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Mechanism in Protein Chemistry
Jack Kyte
Manufacturer: Routledge
ProductGroup: Book
Binding: Hardcover

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ASIN: 081531700X

The Enzymes: Mechanisms of Catalysis (The Enzymes)

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The Enzymes: Mechanisms of Catalysis (The Enzymes)
David S. Sigman
Manufacturer: Academic Pr
ProductGroup: Book
Binding: Hardcover

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Bacterial and Eukaryotic Porins: Structure, Function, Mechanism

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Bacterial and Eukaryotic Porins: Structure, Function, Mechanism

Manufacturer: Wiley-VCH
ProductGroup: Book
Binding: Hardcover

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Book Description

This first book dedicated to the topic relates the known physiological functions of porins to their molecular structure and mechanism, as documented by various in vitro and in vivo methods, including the generation of null mutants in mice.
For the first time, it brings together biophysical evidence with studies performed in a cellular context, presenting a unified picture of the fundamental importance of porins for cellular function.
With 16 contributions by an interdisciplinary team of leading porin researchers, this reference is essential reading for every molecular or structural biologist with an interest in this essential protein family.

Comprehensive Natural Products Chemistry : Enzymes, Enzyme Mechanisms, Proteins and Aspects of NO Chemistry

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Comprehensive Natural Products Chemistry : Enzymes, Enzyme Mechanisms, Proteins and Aspects of NO Chemistry

Manufacturer: Pergamon Pr
ProductGroup: Book
Binding: Hardcover

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ASIN: 0080431577

Book Description

Hardbound. This volume describes the dramatic advances in studies of the structure and function of enzymes which have led to an understanding of the rich chemistry used by nature to construct molecules and how the enzymes of natural products biosynthesis catalyze these reactions. Natural products are synthesized from simple precursors through a series of enzyme mediated reactions that are exquisitely selective and efficient. Questions about the mechanisms of these reactions and what features of enzyme catalytic sites are important for stabilizing transition states and reactive intermediates have been addressed by combining studies in mechanistic organic chemistry, structural biology, and molecular genetics. Except in rare instances, the enzymes of natural products biosynthesis are not found in abundance, and as a consequence, they are not readily available for study from natural sources. This situation has changed through the dramatic advances in gen

Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 2nd Edition

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Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 2nd Edition
Robert R. Crichton
Manufacturer: Wiley
ProductGroup: Book
Binding: Hardcover

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Book Description

Iron is of fundamental importance for the growth, development and well being of almost all living organisms. Multiple biological systems have been developed for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. e.g. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies; iron has a well established role in infections by a wide range of microorganisms and parasites; there is a close link between iron requirements and cellular division with implications for cancers and other metals such as copper and zinc are closely linked with iron metabolism.

The first edition of this book was published in 1991 and since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of its homeostasis. The explosive use of molecular biological techniques applied to cellular biology of iron metabolism has resulted in a rapid expansion in the literature that has led to the need for this second edition.

This collaboration between five specialist authors covers the fundamental concepts and applied aspects of iron biochemistry. Completely updated it reflects the latest advances in the field and now includes new chapters on iron and cell division and the interactions of iron with other metals.

Exploring the chemistry, biology, biochemistry, physiology and medical aspects of iron in biological systems from microorganisms to man this essential title:

Introduces illustrations and colour photos to make the basic concepts far clearer
Includes new chapters on iron and cell division and interactions of iron with other metals - particularly copper and zinc
Provides additional anecdotes
Incorporates an extensive and up-to-date bibliography
Covers both fundamental and applied aspects

Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 2nd Edition is therefore essential to researchers interested in iron in the areas of:

Biochemistry
Molecular Biology
Microbiology
Cell Biology
Nutrition and Medical Sciences

University lecturers of:

Bioinorganic Chemistry
Inorganic Chemists interested in Biochemistry
Biochemists with an interest in iron metabolism

Health professionals with an interest in iron metabolism diseases

Pharmacologists in drug companies interested in developing novel iron binding drugs

Book Description

This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GÑnnproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins.

Mechanisms of Homogeneous Catalysis from Protons to Proteins

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Mechanisms of Homogeneous Catalysis from Protons to Proteins
Myron L. Bender
Manufacturer: John Wiley & Sons Inc
ProductGroup: Book
Binding: Hardcover

General & Reference | Chemistry | Science | Subjects | Books

Customer Reviews:

A Journey of Discovery.......2001-11-12

Readable and amusing ! As Don Forsdyke explains evolution and the human stories behind its discovery he discovers the answer was almost in own backyard.

Amazon.com

The success of Jerry B. Jenkins and Tim LaHaye's fast-paced apocalyptic Left Behind thrillers is built on a straightforward Christian message and a blend of dialogue and action; the 10th installment of the series, The Remnant: On the Brink of Armageddon, sticks to the same proven formula that has captivated legions of fans. It's one month into the Great Tribulation, and a million people gather in the ancient city of Petra to await the foretold "Glorious Appearing." The Global Community loses no time in bombing the city, which is completely engulfed in flames, guaranteeing certain doom for those assembled unless a miracle occurs. In other parts of the world, martyrdom continues for the remnant of believers as Global Community potentate Nicolae Carpathia's thirst for blood escalates. There are lots of slick escapes, plenty of intrigue, some genuinely gory moments, and enough gruesome plagues straight out of the biblical Book of Revelation to keep readers turning the pages. When the Chicago believers are forced to scatter and discord breaks out among those gathered at Petra, changes accelerate for the Tribulation Force and other series characters, leaving an ample number of loose ends to be picked up in the next episode. --Cindy Crosby

Book Description

The incredible tenth book in the international best-selling Left Behind series is now available in paperback. The Great Tribulation unfolds as the forces of evil and the armies of God prepare for mankind's ultimate battle. Millions of Christians are protected by God as the anger of the Antichrist, Nicolae Carpathia, burns against them. Over 2.5 million copies sold in hardcover.

Customer Reviews:

Just one more book in the all-encompassing, enthralling, and utterly absorbing Left Behind Series.......2007-09-14

From the very first letter of the alphabet that my eyes looked upon inside this series of books, until the very last period of the very last sentence, I was hooked. Each one of these books absorbed my attention like no other book has ever done in my life. Biblically sound, theatrically entertaining, and brilliantly written, the Left Behind books will inspire you to dig into God's word and take the pieces of news from your T.V. screen and match them right smack-dab up with the prophecies of the Bible. Your hair will stand up, your heart will race, and you will find yourself helplessly caught in the suspense. Once you finish one of these books, you will desperately race to your computer screen or your local library to pick up the next one!

Carrie Lynn Jones
Author of It All Began... When Jesus Gave Me Sneakers

GREAT listening!.......2007-08-26

My husband enjoyed reading all of the left behind books but I am not much of a reader so I bought them each on audio and listened in the car on the way to work and such. The readers keeps your attention with different voices and sound effects. GREAT TAPES!

ANOTHER LAHAYE FIVE STAR.......2007-03-09

THIS IS ONE OF THE MOST EXCITING IN THE SERIES. IT IS DIFFICULT TO
CONTINUE WRITING REVIEWS ON THE LEFT BEHIND SERIES WHICH IS BEYOND
WORDS. CAN'T PUT THEM DOWN FOR FOOD OR SLEEP.
I BUY 2 COPIES AND GIVE 1 AS A WITNESS.

Read the first 9 .......2007-02-01

This is #10 in the series, so make sure you read the first 9. If you try to read this without the other 9 you will be lost.
This book in itself is a great story of a group of friends trying to make it to the return of Jesus Christ to the world. I am not going to give away the story, read the series. It's a real awakening.

Definitely a Page Turner.......2007-01-26

To me this was like reading a science fiction story. I did not feel that any of it could happen. Of course, that is my perception. It was fast moving and unpredictible. I thought it was an overall good read. By the time you have gotten to the 10th book you care and wonder what is happening with the characters.

The Remnant: An Experience in Sound and Drama: On the brink of Armageddon (Left Behind)

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The Remnant
Why continue to be deceived...
Okay, but no great.
I'm first to review it!

The Remnant: An Experience in Sound and Drama: On the brink of Armageddon (Left Behind)
Jerry B. Jenkins
Manufacturer: Tyndale Audio
ProductGroup: Book
Binding: Audio CD

General | Fiction | Religion & Spirituality | Subjects | Books

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ASIN: 0842343466

Book Description

The Experience in Sound and Drama series of audio products from Left Behind have captured the minds and ears of fiction fans worldwide. Aired on hundreds of radio stations nationwide as well as the World Wide Web, this package of 12 new episodes will make a total of 120 episodes available in this format. Based on The Remnant, which was released in July 2002 and sold millions in hardcover.

Customer Reviews:

The Remnant.......2007-06-09

Great! The entire series is wonderful. The authors had to have a special inspiration from God in putting together the details. I listened to this about 6 years ago and again this month--today, I can see the progression of earth's events--just as depicted in the audio. One suggestion: would like to have had musical effects and sound better balanced--small parts were barely audible others overwhelming. Overall...I would definitely recommend it--and would listen again!

Why continue to be deceived..........2006-06-26

Tim LaHaye, Jerry Jenkins, and others in the Pre-Trib circle, such as Ed Hindson, Tommy Ice, Chuck Missler, etc., continue to put forth the same deceptions that Hal Lindsey popularized decades ago. The notion of a pre-tribulation rapture is foreign to scripture, it is foreign to the teachings of the early Church, and it is grooming the Church for destruction through ignorance and lack of preparation for what is really coming. These men are novices and not prophecy "experts" or "scholars" by any stretch of the imagination; they are those who tickle the ears of gullible Christians. Why continue to be deceived? Tim Cohen, in his excellent book, "The AntiChrist and a Cup of Tea," provides biblically sound and testable evidence to show that the coming AntiChrist is known NOW. Not only that, the same author (Tim Cohen) has now put out the strongest presentation on the whole issue of the rapture EVER offered to the saints of God in Christ: "The REAL Rapture". If you really want to know the truth about the timing of the coming rapture, then you need to hear Tim Cohen's "The REAL Rapture" (based on a volume in his forthcoming "Messiah, History, and the Tribulation Period" series (see Prophecy House's site for details on these items, which are also available via Amazon).

Okay, but no great........2003-04-12

This book spends more than 2 CD's on a rescue mission to save George, which I think was too much time. I am saddened by the brave Steve Plank (main character from books 1-2)but happy that he was a believer. This book does not feature another battle between Nicolae and Micah, like book #9 did, but I wish it did.

I'm first to review it!.......2003-02-15

...It's excellent! It lives up exactly to the book, and dramatises it perfectly. What more can I say? It truly is an experience in sound and drama.

They create an unbelievable sense of reality by using the theater of the imagination. Thus, using a fraction of a movie budget, they create a movie-of-the-mind. Fitting voices, awesome acting, super-cool music, incredible effects, and masterful sound all create the ultimate "experience in sound and drama" for Left Behind's 10th book.

By the way, when they say it's abridged, the audio team cuts some corners, but ONLY in the interest of the listener...I know the books, and I have all the audios, and they work together perfectly...if the audio does not indeed surpass the book.

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The Remnant: On the Brink of Armageddon (Left Behind No. 10)
Tim LaHaye; Jerry B. Jenkins
Manufacturer: Tyndale House Publishers
ProductGroup: Book
Binding: Hardcover

General | Jenkins, Jerry | ( J ) | Authors, A-Z | Religion & Spirituality | Subjects | Books
ASIN: B000OLF53W

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The Remnant - On The Brink Of Armageddon - The Continuing Drama Of Those Left Behind, Book 10
Tim; Jenkins, Jerry B. Lahaye
Manufacturer: Tyndale House
ProductGroup: Book
Binding: Paperback

General | Jenkins, Jerry | ( J ) | Authors, A-Z | Religion & Spirituality | Subjects | Books
Paperback | Jenkins, Jerry | ( J ) | Authors, A-Z | Religion & Spirituality | Subjects | Books
ASIN: B000K1MVWE

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The Remnant - On The Brink Of Armageddon - The Continuing Drama Of Those Left Behind, Book 10
Tim; Jenkins, Jerry B. Lahaye
Manufacturer: Tyndale House
ProductGroup: Book
Binding: Hardcover

General | Jenkins, Jerry | ( J ) | Authors, A-Z | Religion & Spirituality | Subjects | Books
ASIN: B000K1OIGQ

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The Remnant :On the Brink of Armageddon (Left Behind, Volume 10)

Manufacturer: Recorded Books LLC
ProductGroup: Book
Binding: Audio CD
ASIN: 1402536496

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THE REMNANT ON THE BRINK OF ARMAGEDDON

Manufacturer: Tyndale House
ProductGroup: Book
Binding: Hardcover

General | Jenkins, Jerry | ( J ) | Authors, A-Z | Religion & Spirituality | Subjects | Books
ASIN: B000H3AF5A

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The Remnant: Left Behind, Volume 10 (Unabridged)
Jenkins, Tim, Jerry LaHaye
Manufacturer: audible.com
ProductGroup: Book
Binding: Audio Download
ASIN: B000165IK0

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The Remnant: On the Brink of Armageddon
Tim & Jerry B. Jenkins LaHaye
Manufacturer: Tyndale House Pub.
ProductGroup: Book
Binding: Paperback

General | Jenkins, Jerry | ( J ) | Authors, A-Z | Religion & Spirituality | Subjects | Books
Paperback | Jenkins, Jerry | ( J ) | Authors, A-Z | Religion & Spirituality | Subjects | Books
ASIN: B000QIN6NY

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