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This introductory organic chemistry laboratory manual to accompany BROWN'S INTRODUCTION TO ORGANIC CHEMISTRY text contains mini-scale experiments written and organized in a step-wise, easy-to-read approach for students to perform in the laboratory.
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Organic and Biological Chemistry: Introductory Experiments and Exercises
Claudia Hein
Manufacturer: Kendall/Hunt Publishing Company
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ASIN: 0840392168 |
Book Description
Smart genomes--an enthralling account of revolutionary discoveries at the cutting edge of genomics research
Written by a molecular biologist at the forefront of genomics research, Darwin in the Genome is an exciting account of one of the hottest new theories in biology today: evolution by natural selection inevitably leads to strategic mutations. In the struggle for survival, from pathogens to flowers, birds to orangutans, baker's yeast to people, the fittest genomes are those that evolve effective molecular strategies that respond to, and in fact anticipate, challenges and opportunities in their environments.
Writing in a clear, accessible style, Lynn Caporale describes the emergence of genomic mutation strategies, which researchers are just beginning to uncover. She also spells out some of the more profound implications of these findings, including the importance of biodiversity, indeed human diversity, for survival, the possibility of bold new directions for medical research, and the inherent dangers of attempting to fix perceived "errors" in a human genome.
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Written by a molecular biologist at the forefront of genomics research, Darwin in the Genome is an exciting account of one of the hottest new theories in biology today: evolution by natural selection inevitably leads to strategic mutations. In the struggle for survival, from pathogens to flowers, birds to orangutans, baker's yeast to people, the fittest genomes are those that evolve effective molecular strategies that respond to, and in fact anticipate, challenges and opportunities in their environments.
Customer Reviews:
Being good at evolution.......2006-07-19
Back in 1996 Stuart Kauffman, in "At Home in the Universe: the Search for Laws of Self-Organization and Complexity", postulated convincingly on theoretical grounds that evolution would favor organisms which were good at evolution, i.e. they were more likely to generate favorable changes in their genome. Sex is theorized by many to have arisen as a means of responding to the evolution of disease causing agents, as well as to promote evolutionary adaptation in general. I myself, as I am sure many others, always questioned that organisms would have all this junk DNA, costly (in terms of energy) to maintain, without any use. Caporale's book attempts to gather all the evidence currently available that Kauffman was correct, and finds that junk DNA plays a role in facilitating evolution. Caporale also does a lot of speculating, because the body of experimental evidence is still in its infancy. Incidentally, Caporale gives the impression that the postulate I have ascribed to Kauffman (and which undoubtedly had earlier antecedents), is a new idea.
At times Caporale's book is almost painfully detailed in describing biological processes, albeit always without invoking organic chemistry. Her motivation is good: having gone through some concrete detail, for example about "slippery" DNA, the reader should be better able to appreciate the more general arguments. Caporale loves sustained metaphors; often the metaphors help, sometimes they get in the way. In general, I found the book uneven. The critical chapter on jumping genes left me with too many questions that I attribute to the writing. The final chapter, instead of being a much needed summary, presents material that anyone sophisticated enough to get that far, already knows. On the other hand, the chapter on the immune response was clearer than other accounts I have read, and the general topic of processes favoring successful evolution is fascinating. So my advice is: if you are already conversant with evolution, and willing to deal with some challenging material, perhaps sometimes unnecessarily challenging, read this book. In case you do not, I must point out that I was delighted to learn that there is now evidence that the intron RNA is not immediately destroyed after protein synthesis, and likely has some function to perform.
How Our Genomes Generate Variation to Promote Evolution.......2006-04-12
Darwin postulated that evolution resulted from the accumulation of small variations from generation to generation. Once Watson and Crick described the structure of DNA, many people thought that variation arose mostly from point mutations: changes, insertions, and deletions of single "letters" of the DNA code. Since then, it has become obvious that larger changes are more important. For example, whole segments of DNA, including genes and gene families, are duplicated; the copies are then available to be modified for new purposes while the originals still do their old jobs. A number of other books look at how such large changes promote evolution; this book focuses on molecular mechanisms behind these changes, i.e. where the variation comes from.
For example, there are molecular mechanisms that cut sequences of DNA from a chromosome, and other mechanisms that patch those sequences back into the DNA in other places. Such changes can affect the interactions of genes and so influence evolution. Other mechanisms will copy instead of cutting and will therefore provide the material for creating new genes. This book pays more attention to the molecular processes that make changes happen than to the evolutionary consequences of genetic changes and thus it complements a number of other books on the market.
Caporale, a medical researcher, gives special attention to bacteria and cancer on one side, and our bodies' defenses on the other. This gives examples that are relevant to readers' lives and also gives readers some insight into important medical issues. And, again, it means her book contains a lot of material that some other books don't have.
I see two minor weak points in the book. First, on page 130, she gives the impression that the material is a bit speculative, using such phrases as "I am convinced" and "the idea that I have proposed". In fact, as she says later in the book, specific gene mechanisms that make some mutations more likely than others are well known. Second, she uses "random" to mean that not all events are equally likely, even though there is nothing deterministic involved. I.e. there is no guiding power which says, e.g., "This DNA segment should be duplicated now." I mention these points because the text can easily be cited by creationists to cast doubt on the existence of evolution. But these don't detract from a very good book.
I found this book to be a very easy read and I feel certain that almost anyone who is thinking about buying this book will have no difficulty either. The main thing you need is a modest knowledge about genes. At least that is my judgment and, although my knowledge of evolution is rather extensive for a non-scientist, I think I have a good feel for what others can read. For more about this, click on my name, above, and read the "In My Own Words" section.
You might also be interested in other books about ways in which nature promotes evolution. I have listed several of these, along with some background information, in my Listmania list "Natural Processes That Promote Evolution", a link to which can be found by clicking on my name. These are books which I have reviewed and which I recommend.
[Added 31 Jan 2007] The first time through, I didn't pay close attention to the chapter on cancer. I read it again after I had developed a personal interest in cancer and had read a book entirely on the biology of cancer. Now I see this as an excellent chapter. Because cancer lives in a relatively simple ecosystem (e.g. my insides) and since it goes through a relatively small number of evolutionary steps, it is a good model to start with.
The Dancer and the Dance.......2006-03-13
Imagine you're sitting in the audience at a play, one with a large cast and a complex plot, Les Miserables, say, or Nicholas Nickleby. Only this play isn't presented in the usual way. Sometimes you see the actors but you can't hear them speak. Other times the curtain hides the stage, but you can hear the actors clearly. And sometimes you can both see the actors and hear them deliver their lines. After sitting through this odd drama, you're required to provide a detailed critique of the play to someone who hasn't seen it.
Some of what happened you'd know for certain, some of it you'd try to infer by piecing together partial information, and some of your explanation would be sheer guesswork. This seems to approximate current scientific writing about the human genome: some knowledge, some inference, some guesswork. We've learned a considerable amount about the overall structure of our genome during the past two decades. But there's a lot about the mechanics of how genes duplicate, edit and regulate themselves that remains hidden from us. Molecular biologist Lynn Helena Caporale uses her considerable knowledge of genomic functioning to update us on the current state of play and to buttress some speculative thinking about how genomes mutate. Her conclusions are controversial among evolutionary theorists, but they do provide a possible answer to a particularly bedeviling question: given the trillions of potential pathways and cul de sacs down which random mutation could have taken our genes, how did homo sapiens actually evolve to this level of functioning in the relatively short time we've been on the planet?
Dr. Caporale's thesis is that mutation might not be completely random. Instead, she speculates that genes may have evolved strategies for allowing high levels of variation in targeted areas for targeted purposes - fighting off bacterial infections, for example - in ways that don't disturb the essential functioning of the organism. As she states in the prologue, "a genome evolves a `worldview' of which types of changes, under what types of circumstances, may yield a new function and are less likely to destroy something essential."
Such genomes would have an evolutionary advantage because they could generate diverse offspring or adapt to new circumstances without having to rebuild what already works from scratch. She also demonstrates that our DNA can cut and paste blocks of genetic information, which means that we can take successful subroutines and recombine them to create new functions, similar to the way object oriented programming works in computer software. (We may have acquired some useful code from interactions with our good friends, bacteria, or our close cousins, the mouse and the fruit fly.) If genes work this way, then our evolution may have been more strategic and targeted than purely random mutation would account for, and natural selection would naturally favor the genomes with the most workable strategy for surviving and successfully replicating themselves.
Among the many fascinating glimpses into our functioning that this book provides are the strategies our cells employ to recognize, capture and neutralize viruses. There's an epic conflict going on in your gut at this very moment that makes the climactic battle scenes in Lord of the Rings look tepid and unimaginative. It's also fascinating to realize that our genes enact on the cellular level one of our most profound human dilemmas: how do you decide what should remain stable and what should change in order to secure the best future for yourself? Is the human dilemma just the basic genomic dilemma writ large? As the Irish poet William Butler Yeats put it so memorably, how can you tell the dancer from the dance?
There's a lot of detail in this book, and the non-biologist may struggle to absorb the nomenclature of molecular biology, and to track the splits, slips, swaps, loops, cuts, conversions, transmissions and transpositions that the 3 billion letters of your genome engage in. Dr. Caporale employs some elegant metaphors to make the play more intelligible. The reward for paying close attention is a awe-inspiring glimpse into what we are, along with some well-reasoned ideas about why we turned out this particular way.
Secrets of the genome.......2006-01-21
Most accounts of Darwinism are conventional repetitions of tired phrases, and don't let on there is something new afoot in the specialized work of students of molecular evolution. This engaging work describes the processes of non-random mutation that are being discovered at work in the genome, and the result is an eye-opener.
As the author notes:
"The work described in this book has led me to the conclusion that natural selection must work not just on each individual mutation, but also on the very mechanisms that generate genetic variation-as it does on all bio- logical functions. The research discussed in this book leads to the conclusion that mutations are not all accidents and that mutations are not always random. Our genomes, and those of other life forms, have evolved mechanisms that create different kinds of mutations in their DNA, and they reuse and adapt useful pieces of DNA, even to the point that there are genomic 'interchangeable parts.'
Biochemical mechanisms can arise that tend to focus genetic variation, resulting in "hot spots" of genetic change at certain places in the genome."
Good balance, current developments.......2004-06-24
I am not a trained biologist, but I enjoy reading in this area, and I enjoyed this book a good deal.
Basically, her thesis (which appears most clearly on page 130) is that genetic mutations are not random and are to some degree controlled by a meta-program of the DNA regulators that is subject to selection pressures. She posits an evolutionary theory, but spends most of her time gently explaining the actualities and details. She shows that her theory happens in the immune system and then makes reasonable suppositions that it probably happens on a broader scale. There are a lot of perhaps's and probably's in the book. She acknowledges that parts of her theory are controversial.
She is much clearer and less freighted with philosophical rhetoric than Lenny Moss's "What genes can't do," and she describes the complex genetic interaction with other cellular structures and exterior signals with almost as much subtlety. I liked her description of bacteria using quorum-sensors to decide whether to break apart as plasmids or whether to hunker down in a spore. She also seems to have an eye on the issues raised by IDist Michael Behe and makes a point of discussing the immune system and blood clotting as very much reducible and evolved mechanisms, though she doesn't attack creationism directly.
I give the book a four star because her prose is not as inspired as that of Stephen Jay Gould or Steven Pinker, and her metaphors don't always fly. Her grand gesture at the end did not leave me overwhelmed. There is still a lot of technical vocabulary, so not quite a light read, but much lighter than many. It will allow even smart high schoolers to learn the latest theories on that Mother of All Rube Goldberg Machines: Life.
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Molecular Strategies in Biological Evolution (Annals of the New York Academy of Sciences)
Manufacturer: New York Academy of Sciences
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Binding: Hardcover
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ASIN: 1573311928 |
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Behavior of Dense Media Under High Dynamic Pressures
Iutam
Manufacturer: Routledge
ProductGroup: Book
Binding: Hardcover
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ASIN: 0677137109 |
Book Description
In Beyond the Breakwater, Sheriff Reese Conlon and Doctor Tory King face the challenges of personal change as they define their lives and future together. Tory's pregnancy forces her to examine her personal needs and goals while Reese struggles with her escalating anxieties over conditions she cannot control. Twenty-year-old Brianna Parker makes a sacrifice for love that threatens not just her happiness, but her life, when she returns home as the newest member of the Sheriff's department. A life-threatening accident, a suspicious fire, and the appearance of more than one woman vying for Bri's attentions makes one Provincetown summer a time of transformation as each woman learns the true meaning of love, friendship, and family.
Customer Reviews:
PTown Romance & Drama.......2006-09-07
Back in P-Town for the sequel of "Safe Harbor", Reece Conlon has a new recruit under her wings. Bri Parker, the sheriff's daughter has returned home to join the law enforcement unit of P-Town.
Her partner, Caroline has gone to France for a year of education for her degree. They are missing each other and stupid crap starts happening making them doubt each other because they don't get the big picture.
Tory is pregnant and still hold down her practice. Reece is working hard on training with Bri; preparing herself for their new bundle of joy; and keeping watch over P-Town.
There's lots of hot action in this sequel.
Beyond the Norm.......2006-06-13
The plot of this book is as described elsewhere.
Whether you read Radclyffe's series books, like the Justice series or the Honor series or the Provincetown series, or you read one of her stand-alone romances, you can not go wrong.
I have been reading lesbian fiction for many years, and can honestly say that I have never come across a writer that has so affected me. Her characters are strong, intelligent, and romantic. Naysayers will say that Radclyffe's characters are too perfect almost never flawed - either in looks or character. That may be true, but aren't you tired of the genre's penchant for ordinary? Radclyffe's characters are always enchanting, intoxicating, enticing, and intense. The stories, particularly in the series books, are all first class. Most of her series books are page-turners. And in two of the books, I actually turned to the last page to make sure that the main characters survived - something I never do.
Radclyffe let us believe, at least for the duration of each of her books, that the grand passion, the true love, the happy-ever-after are all possible. She lets us believe that being a strong, intelligent woman does not mean that we will be alone and/or isolated.
The only caveat I have is to read the series books in order. And if you enjoy watching a writer grow, then read the non-series books in the order they were written and watch Radclyffe's talent grow before your very eyes.
Radclyffe Hasn't Written a Bad Book.......2005-01-10
I read this book for the first time in late 2003 and finished the paperback version last week to prepare for the next in the series to be released in 2005. I thoroughly enjoyed this sequel to Safe Harbor. Radclyffe takes the inexperienced, but faithful, Reese and the jilted Tory down the road of starting their own family. She also explores the relationship of the young lovers Brianna and Carre as they begin to cross over into adulthood. Radclyffe delivers turmoil, mystery, problems with pregnancy, relationship fears, and so much more. This book takes the reader on many emotional highs and lows, and is highly recommended by this reviewer.
Super Read - 4 great characters.......2004-11-27
I liked the first novel in this series and expected to enjoy this book. I Loved it ! The romance between the 2 main characters was wonderful. What kept me from putting the book down until finished was the rocky relationship with the two secondary characters. I kept wanting to knock some sense into one of them. Throughly enjoyable read.
Look for the newest edition published by Bold Strokes Books October 2004.
This is a Keeper !
Don't miss all the books in this series -
Safe Harbor
Beyond the Breakwater
Distant Shores, Silent Thunder
Storms of Change - available October 2006
A Sequel As Good As The First.......2004-04-20
Take the romantic setting of Provincetown, add a sexy doctor and a gorgeous sheriff and you have the makings of an amazing, passionate, love story. In this sequel to SAFE HARBOR, Radclyffe again takes us into the lives of Reese and Tory and their family and friends. This story is as compelling and well written as the first and just as hot. If not hotter. Radclyffe is the leader in sensual, erotic, sexy love scenes. She boldly goes where other authors fear to go. You will not be disappointed.
It's about time there was a fresh approach to lesbian romance and Radclyffe is it.
Book Description
This comprehensive book covers all major aspects of the design and maintenance of port facilities, including port planning, design loads for today's larger vessel size, seismic design guidelines, and breakwater design. New material addresses environmental concerns, the latest developments on inter-modal hubs and transfer points, and the latest information on port security and procedures being implemented around the world.
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- Talking in Riddles
- TSTL
- One of a series - probably should read the others first
- Suspenseful.......
- JUMP IN - BREAKWATER'S TERRIFIC
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Breakwater (Mira Romantic Suspense)
Carla Neggers
Manufacturer: Mira
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Dark Sky (Mira Romantic Suspense)
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The Waterfall
ASIN: 0778322378 |
Book Description
An idyllic cottage. An unlikely suicide. A conspiracy that could blow the lid off the Department of Justice.
Three months ago Quinn Harlowe left the high-pressure hallways of the Justice Department to become an independent consultant and have more control over her life -- maybe even have a life. But the nirvana of her new gig is short-lived when Quinn discovers her friend and former colleague Alicia Morrow dead outside Quinn's bayside cottage. Suicide? Quinn is doubtful.
Investigating on her own, she soon discovers that someone is following her every move. Huck McCabe claims he's a bodyguard at Breakwater, a high-security compound near Quinn's cottage. But Quinn suspects he's lying, never imagining the truth: McCabe is an undercover agent trying to penetrate a violent network of vigilantes -- the same people Quinn has identified. Joined by a common goal, Quinn and McCabe must fight the bastion of law and order . . . a fight they know could lead to disaster.
Customer Reviews:
Talking in Riddles.......2006-08-17
Who to trust? That's the ultimate question. It is a world of law enforcement, government sector, high profiles, and criminals. Betrayal seems to be the main subject matter. A woman starts acting recklessly and her friend later found her dead. The friend thus investigates not knowing that a big undercover is taking place which coincides with her pain of losing a friend. The writer tries to confuse the reader with many different characters and secretive typed dialogues. Good plot but with disconnected tendencies the story appears bland.
TSTL.......2006-08-14
Like another reviewer Quinn fit into the TSTL (too stupid to live) for me. She may have only been a historian at the Justice Department but certainly knew something about being covert. She just plowed right in, confronted people with her suspicions and told them everything she knew. She used no discretion at all and was practically ringing the dinner bell and saying, "Here I am, come kill me because it's the only way I'll stop running my big mouth!" I realize this is part of the series but I'm not interested in reading anymore books by Ms. Neggers.
One of a series - probably should read the others first.......2006-08-08
Former Justice Department researcher Quinn Marlowe discovers the decomposing body of her friend Alicia at her seaside cottage. The last time she saw Alicia, she was incoherent, appeared to be suffering from a breakdown, and disappeared into a limo. Undercover US Marshall Huck McCabe is jogging by when she makes the grisly discovery and tries to aid her. And he continues to have a growing interest in her as she investigates the events surrounding Alicia's death, bringing her to the very people he is trying to link to a vigilante group headed by a wealthy CEO that was a victim of kidnapping.
Quinn's snooping gets her into hot water and it is all Huck can do to get her to abandon her search for her own safety. But n the grand tradition of being far too stupid to live, she not only continues to investigate, but alienates mot people she comes into contact with, thus putting herself in the forefront of danger.
This is my first Carla Neggers book. I felt like I was in the middle of a two hour movie that had already been on for at least an hour and a half. There are so many characters - most with little background to differentiae them from others - it was obvious that this was one of a series of books. I struggled to tell them all apart (many only made a casual entrance in the story then disappeared altogether). The synopsis on the back made the plot sound interesting - but it was a truly disappointing read. I found the minor characters like Nate Winter and Juliet Longstreet more interesting. And lo and behold, they have their own stories.
Suspenseful..............2006-06-23
This book kept me intrigued. The author brings you into the book with great details of the characters (sometimes too much) but hey it was still worth it. This is my first book of Neggers and from this first one I plan on reading more. Breakwater is a mystery/romance and even action pack book. The deception alone will make you want to keep reading to see who is really the bad guys (vigilantes) and who are good. I love the way the book ended and made me want a sequel just to see if Miss Quinn keeps her nose out of police business and what will happen to her and Huck.
JUMP IN - BREAKWATER'S TERRIFIC.......2006-02-17
I've been madly in love with several of Ms. Neggers hero's for years. They'll now have to make room for Huck McCabe. He is wonderful, as is her heroine Quinn Harlowe. Together they create a truly thrilling story. Ms. Neggers knows how to create rich, full of life characters, weaving them into a mix that is fast paced, suspenseful and romantic. If you like romantic suspense, you can't go wrong with Breakwater.
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Coastlines, Structures and Breakwaters 2005
Institution of Civil Engineers
Manufacturer: Thomas Telford, Ltd.
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Binding: Hardcover
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ASIN: 0727734555 |
Product Description
The Coastlines, Structures and Breakwaters conference series is internationally recognised for its balanced spread of presentations, research, design, construction and a strong emphasis on practical application. This book presents international experience in design and construction practice and describes recent improvements in analysis and prediction methods. Recent research results include new guidance on wave loadings; advances in predicting wave overtopping; effects of climate change on coastal flooding; and improvements in hazard and reliability analysis. Papers on wave overtopping and wave loadings have significantly improved the understanding of the complex processes involved, with new guidance from the European CLASH project on the magnitude of overtopping hazards and their distributions, methods to correct scale and model effects for low discharge overtopping, and use of new prediction tools including Neural Networks and numerical models. The importance of good understanding and prediction tools for overtopping responses is illustrated by papers on seawall experience from Japan, reliability methods for sea defences in the UK, and results from the major Foresight project on flood risks over the next 30-100 years.
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Breakwater
Carla Neggers
Manufacturer: Doubleday Large Print
ProductGroup: Book
Binding: Hardcover
ASIN: 0739464647 |
Product Description
Large print romantic suspense
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- sand and gravel
- sand and gravel
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Berm Breakwaters: Unconventional Rubble Mound Break Waters
D. H. Willis , and
W. F. Baird
Manufacturer: Amer Society of Civil Engineers
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ASIN: 0872626636 |
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sand and gravel.......1999-04-20
In beach or river, the difference of sand transport and gravel transpor
sand and gravel.......1999-04-20
In beach or river, the difference of sand transport and gravel transpor
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Breakwaters and Closure Dams
K. d\\\'Angremond and F.C. van Roode
Manufacturer: VSSD
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ASIN: 9040721270
Release Date: 2006-01-25 |
Book Description
Text book on design and construction of breakwaters and closure dams.
Product Description
3 Books (1 Heather Graham, 2 Carla Neggers) : 1) The Presence / 2) Breakwater (Mira Romantic Suspense) / 3) Claim The Crown (Unboxed Set of Books), Shipped in one package to save on shipping costs.
Product Description
Multiple books shipped as one item for your convenience. Save on Shipping/Handling charges.
Books:
- Materials Science in Static High Magnetic Fields
- Metal Ions in Biological Systems
- Metal Oxides: Chemistry and Applications (Chemical Industries)
- Metallocenes 2e V1 & 2 - Synthesis, Reactivity, Applications
- Modeling and design of step-growth polymerization in reactive distillation processes
- Modern Quantum Chemistry: Introduction to Advanced Electronic Structure Theory
- Modern Tools and Methods of Water Treatment for Improving Living Standards: Proceedings of the NATO Advanced Research Workshop on Modern Tools and Methods ... IV: Earth and Environmental Sciences)
- Multidimensional Solid-State NMR and Polymers
- N4-Macrocyclic Metal Complexes
- New Developments in Polymer Analytics I (Advances in Polymer Science)
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