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Peptide and Protein Drug Delivery (Advances in Parenteral Science, No 4)
Manufacturer: CRC
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ASIN: 0824778960 |
Book Description
This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai
Book Description
Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up-to-date, relevant information on protein formulation and/or delivery systems and the need for a new edition is self-evident. This second edition continues the tradition of providing a ready-to-use reference of accurate information, tables, and illustrations. The book begins with the basics of the origin of recombinant proteins, explores structural and analytical aspects, and moves on to discuss the stability of proteins and peptides. Against this background, the author addresses preformulation and formulation considerations and provides detailed information on important topics such as lyophilization. He goes on to discuss various delivery systems, including controlled release delivery systems and products currently on the market. The book also contains newly added regulatory information and thoroughly investigates therapeutic drugs made from proteins as well as protein-based vaccines. A new chapter on recombinant protein subunit vaccines and their delivery systems has been added. The work of a single author, the book provides complex information in a simple, elegant, and cohesive style. The author minimizes overlap between coverage and includes extensive cross-referencing that links related topics. Completely revised and updated, packed with cutting-edge information, the second edition once again fills the need for a reference that pulls all the relevant information together into one resource.
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Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids
Manufacturer: CRC
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ASIN: 0849323347 |
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Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present biological barriers to extravasation and cellular uptake of proteins and nucleic acids. Combining an introduction to biomaterial delivery with the latest developments in the field, this is a valuable reference for both the novice student and the practicing scientist on delivery of biomaterials, on biomedical polymers, and on polymer therapeutics. Understanding these core fundamentals is critical to moving on to more advanced study.
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Delivery Systems for Peptide Drugs (Nato Asi Series a, Life Sciences, Vol 125) (Nato Science Series: A:)
S.S. Davis ,
Lisbeth Illum , and
E. Tomlinson
Manufacturer: Springer
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Binding: Hardcover
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ASIN: 0306424967 |
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Peptide Transport and Delivery into the Central Nervous System (Progress in Drug Research)
Manufacturer: Birkhäuser Basel
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Binding: Hardcover
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ASIN: 3764367164 |
Book Description
Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics could be useful in the treatment of diseases of the central nervous system. This book provides an overview of the role and neuropharmaceutical potential of these peptides, and discusses the state of the art and future trends in the use of peptide pharmacotherapy involving the brain.
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Targeting of Drugs, Volume 3:: The Challenge of Peptides and Proteins (Nato Science Series: A:)
Manufacturer: Springer
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Binding: Hardcover
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ASIN: 0306444003 |
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Therapeutic Protein and Peptide Formulation and Delivery (Acs Symposium Series)
Manufacturer: An American Chemical Society Publication
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Binding: Hardcover
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ASIN: 0841235287 |
Book Description
This volume reviews protein stability and the analytical and biophysical characterization of proteins. It emphasizes drug delivery approaches, especially local delivery through the skin. Including both academic and industrial perspectives from such companies as Genentech, Amgen, and Merck, the book also discusses novel drug delivery polymers and the development of pharmaceutical protein formulations.
Book Description
Peptide and protein drug delivery research has been moving at a brisk pace for over 10 years. Trends and Future Perspectives in Peptide and Protein Drug Delivery is a collection of snapshots of the major past and future developments in this exciting field as seen by over 20 invited speakers at a three-day conference on protein drug delivery held on September 2-4, 1993, in Kyoto, Japan. The wide-ranging topics covered included polymeric delivery systems for protein drugs, means of enhancement of protein drug transport, protein modification for improved pharmacokinetic/pharmacodynamic properties, targeting of peptide and protein drugs, and delivery of oligonucleotides and genes.
Book Description
This digital document is an article from BIOTECH Patent News, published by Biotech Patent News on September 1, 2004. The length of the article is 568 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details
Title: Corgentech licenses peptide delivery system from Cyclacel.
Publication:
BIOTECH Patent News (Newsletter)
Date: September 1, 2004
Publisher: Biotech Patent News
Volume: 18
Issue: 9
Distributed by Thomson Gale
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Orogenic Processes: Quantification and Modelling in the Varsican Belt (Geological Society Special Publication)
Manufacturer: Geological Society of London
ProductGroup: Book
Binding: Hardcover
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ASIN: 1862390738 |
Book Description
Research into the orogenic processes that shaped the continental crust of Europe has a long-standing tradition. Why the need to quantify and model? It is not just satisfactory to identify subduction zones, accretionary prisms, island arcs, extensional collapse and other standard items of the geodynamic menu. Such interpretations need to be quantified: extent and composition of subducted crust, angle and speed of subduction, amount and composition of melts produced, heat sources for metamorphism. All such interpretations have to conform to first principles, and also to stand the test of quantitative balancing - a concept first developed for the conservation of length or volume in tectonic cross sections. Also in other fields, the correlation of causes and effects and the internal consistency of dynamic models requires a numerical approach.The present volume combines review articles with reports on recent progress in the attempt to address these aims. There is a foldout map of the region, which locates the main areas of outcrop and tectono-stratigraphic units, and a reassesment of the Palaeozoic time scale permits correlation of tectonic, metamorphic and magmatic events with the sedimentary record of the upper crust.
Readership: Earth Scientists, Research academics interested in tectonics, Stratigraphers, Sedementologists.
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Pseudo-Differential Equations & Stochastics Over Non-Archimedean Fields (Pure and Applied Mathematics)
Anatoly Kochubei
Manufacturer: CRC
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Binding: Hardcover
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ASIN: 0824706552 |
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Provides comprehensive coverage of the most recent developments in the theory of non-Archimedean pseudo-differential equations and its application to stochastics and mathematical physics--offering current methods of construction for stochastic processes in the field of p-adic numbers and related structures. Develops a new theory for parabolic equations over non-Archimedean fields in relation to Markov processes.
Book Description
The first time I heard it, I laughed.
Oh, come on, I thought. He didn’t just say that.
We were at a restaurant in southern Ohio, where a hundred or so Democrats and a handful of young campaign workers had gathered to hear my husband, Sherrod Brown, announce for the seventh time in two days why he was running for the United States Senate.
The party chairman of the county stood up at the lectern and in a loud, booming voice, introduced “Congressman Sherrod Brown–and his lovely wife.”
By Week 40 of the campaign, I had been introduced that way nearly a hundred times. I stopped counting once we hit the 50 marker. I knew I was not the point at these gatherings, and I was so proud of the man who was.
Also, I realized I was getting cranky about something I could not change. If I couldn’t rely on a sense of humor, I was in for one long year on the campaign trail.
Writing with her trademark warmth, wit, and common sense, Pulitzer Prize-winning columnist Connie Schultz reveals the rigors, adrenaline joys, and absolute madness of a new marriage at midlife and campaigning with her husband, now the junior senator from Ohio. She describes the chain of events leading up to Sherrod’s decision to campaign for Senate (he would not run without his wife’s unequivocal support) in a state where no Democrat had won statewide office for twelve years. She writes about the moment her friends in the press became not so friendly; the constant campaign demands on her marriage and family life; a personal tragedy that came out of the blue. She gives us a candid behind-the-scenes look at the often ludicrous trials and tribulations of being an opinionated columnist, a political wife, and a newly married woman in her forties, and the rigors of political life: audacious bloggers, ruthless adversaries, campaign fatigue, political divas, the no-small-planes agreement, and staffers young enough to be her children suddenly directing her and her husband’s every move.
Filled with eye-opening revelations about the election process, . . . and His Lovely Wife illuminates through one woman’s story a marriage, our political system, our working lives, and our nation. Connie Schultz is outspoken, passionate, and very public about her opinions–in other words, every political consultant’s nightmare, and every reader’s dream.
Customer Reviews:
Small Airplanes.......2007-09-10
I was on a commercial flight from Cleveland to Washington last Spring. It was a particularly windy day and landing at DCA seemed problematic. On approach, one wing would dip and then the other. There was no applause on landing, but a collective exhale. Ohio's junior Senator, Sherrod Brown, was on that flight.
Connie Schultz is Sherrod's wife, a Pulitzer prize winning columnist for the Cleveland Plain Dealer. ...and His Lovely Wife is her account of discovering the vicissitudes of Ohio politics through the eyes of a campaign wife during her husband's 2006 run for the Senate. The title comes from her irritation at the awkward manner in which she was frequently introduced by those not yet comfortable with married couples with different last names.
The book is a fascinating study of politics and romance, written with great humor and frequently great insight. It is especially readable because of the inclusion of details like Connie's insistance that her husband pledge not to fly in small airplanes during the campaign - too much of a temptation to fly when you shouldn't - too many dead candidates from choosing wrong:something I found ironic after that Spring landing in Washington.
O.K., I'm from Ohio. O.K., I'm sort of a political junkie. O.K. I'm a longtime Sherrod Brown fan. This book just sucked me through. After the few days it took be to go through it, my only disappointment was that there was not more.
A book that gives me hope for America .......2007-09-10
Smart, funny, and honest, ...and His Lovely Wife shows how crushingly difficult it is to run for public office. It also demostrates that there are still some honorable politicians who care deeply about average people. And there are dishonorable politicians willing to lie and slander in order to hang on to their power. (The incumbent Sherrod Brown defeated accused John Glenn--John Glenn--f being unpatriotic and soft on communism. The mind boggles.)
The book is also a lot of fun. Not surprisingly, Connie Schultz writes very well (Pulitzers are not given out as Cracker Jack prizes), and she can be very funny about the lunacy of campaigning. I'm glad Ms. Shultz has been able to go back to her life as a journalist, and I hope this book is read by everyone who cares about American politics and government.
Fluff and Fuzz.......2007-07-07
this is the same Connie Schultz who with her husband attacked the blogasphere and Paul Hackett who would have been a much better senator in my opinion. Unfortunately this state is too politically correct for a true plain spoken public servant such as Hackett. Instead we have a soft Bill Clinton like Hippie and his manly wife who bosses him around. Connie Schultz isn't so much of a crusader for women's rights as she is a leftover from the angry screechie's from the sixties who attack pornography, Miss America, cheer leading, bra's and just about anything else that makes a woman different from a man. Thankfully readers have a real rennaisance women such as Camille Paglia or Wendy McElroy to read instead of this bladerdash.
a bird's eye view of a crucial campaign.......2007-07-07
Schultz writes with humor and passion. She was there every inch of the way as her husband Sherrod Brown fought the underdog's battle and knocked off the incumbent Ohio senator, Mike DeWine. Political junkies will love this inside look at the campaign that shifted the balance of power in the US Senate.
Most telling, Schultz and Brown are progressives with strong Christian beliefs, a real slap across the kisser for all those holier than thou right wingers who trumpet their family values while having affairs on the side: Newt Gingrich-please don't run for office again.
Honest viewpoint.......2007-06-30
So many political memiors are thank you notes to supporters or influential people who can advance a politician's career. But, Ms. Schultz's book provides an outsider a view to the inside of a political campaign as well as to her inner most thoughts (at times) when it came to dealing with her own identity issues. As the book (and campaign) progresses, the reader can see how the humor and energy changes. This is a great read that will take you, from the wife's perspective, through the underbelly of how campaign strategy works and how the opponent's tricks play upon the candidate. It will take you, as well, through the inter mind workings of an intelligent woman who had to change her life and put her career on hold to support someone she loves.
This is not your normal political read. You do not need to be a "political junkie" to enjoy it. Anyone who has ever evaluated their own life, or had to deal with society's stereotypes of how wives and women are to "be"; or just want a good read with humor and insight on life thrown in, will enjoy this book.
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His Current Woman (Hydra Books)
Jerzy Pilch
Manufacturer: Northwestern University Press
ProductGroup: Book
Binding: Paperback
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ASIN: 0810119188 |
Book Description
His Current Woman depicts the comic misadventures of a philanderer and the angry lover in his attic.
Customer Reviews:
Unsure of What It Is.......2004-05-03
I have to confess that this much-acclaimed novella, published in Poland in 1995, really didn't come together in any meaningful way for me. The story follows Pawel Kohoutek, a middle-aged veterinarian in the Cieszyn region who is notable for his infidelity to his wife. The book starts with his looking out the window of his houseówhere he lives with wife, daughter, and a whole host of extended family and hangers-onóto see the titular character striding across the lawn with all her worldly possessions. The remainder of the book concerns his efforts to hide this mistress in a crumbling slaughterhouse adjacent to the house, and conceal her existence from his family. Mixed in with these farcical, Fawlty Towersesque escapades (would that they were that funny) are assorted recollections and partial glimpses into what makes him tick. As even he admits he is a boring, totally run-of-the-mill philanderer, there's not a whole lot to take away from these examinations. There is a certain wit and playfulness to it all, but one could imagine it working better as a film than it reads on the page. Ultimately, it's hard to know what to make of the book. Is it a whimsical look at a funny little fellow and his predicament? Is it a telling commentary on the Cieszyn region of Poland (many allusions are made to the Lutheranism found there, but I have no idea what to make of it). Or perhaps, since it is set in 1990, it's some kind of allegory about the Iron Curtain? It's neither witty enough to hold up as a comic novel, nor opaque enough to stand out on any other terms. One wonders whether reviewers are perhaps giving it "bonus points" for being Polish?
Book Description
This digital document is an article from The Review of Contemporary Fiction, published by Review of Contemporary Fiction on September 22, 2002. The length of the article is 1265 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details
Title: Jerzy Pilch. His Current Woman.(Book Review)(Brief Article)
Author: Brian Budzynski
Publication:
The Review of Contemporary Fiction (Refereed)
Date: September 22, 2002
Publisher: Review of Contemporary Fiction
Volume: 22
Issue: 3
Page: 158(2)
Article Type: Book Review, Brief Article
Distributed by Thomson Gale
Book Description
This digital document is an article from World Literature Today, published by University of Oklahoma on April 1, 2003. The length of the article is 531 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
Citation Details
Title: Jerzy Pilch. His Current Woman.(Book Review)(Brief Article)
Author: Norbert Schurer
Publication:
World Literature Today (Refereed)
Date: April 1, 2003
Publisher: University of Oklahoma
Volume: 77
Issue: 1
Page: 149(1)
Article Type: Book Review, Brief Article
Distributed by Thomson Gale
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