Guide to Mutation Detection

Book Description

As genomic science and potential gene therapies continue to develop, the detection of mutations plays an increasingly central role in diverse areas of biology. With innumerable detection techniques available spanning multiple disciplines, the choice of the best method for a particular study can prove exceedingly difficult. Complexity, equipment requirements, cost, and throughput are all factors to consider, along with the huge amount of information already available through genome sequencing projects.
An essential go-to for informed decision-making, the Guide to Mutation Detection is the only single source for the theory and practice of mutation analysis needed to design an experiment. User-friendly, concise, and expertly edited by recognized leaders in the field, the text provides a cutting-edge reference that is still accessible to those with no experience in mutation analysis.
The coverage is divided into two sections, with the first section reviewing such topics as:
* Key technologies
* Mutation scanning
* Cleavage
* Quality control
* High throughput approaches
* Databases
* Nomenclatures
The second section focuses on step-by-step protocols and discussion of methods, including:
* Tag-array minisequencing
* Electronic hybridization
* Pyrosequencing
* Fluorescent Single-Stranded Conformation Polymorphism (SSCP)
* Denaturing High-Performance Liquid Chromatography (DHPLC)
* Array Comparative Genomic Hybridization (ACGH)
* Microplate Array Diagonal Gel Electrophoresis (MADGE)
Throughout the text, the emphasis remains on practical applications. The detailedprotocols derive from the well-regarded Human Genome Organization (HUGO) training course, particularly those in Montpellier, France, 2002, organized by Mirielle Claustres, Johan den Dunnen, and Graham Taylor. Useful appendices contain important safety data, supplier lists, and bioinformatics resources.
Up-to-date, user friendly, and comprehensive, the Guide to Mutation Detection is an invaluable resource for students and practitioners working across a wide range of genetics-related disciplines.

Genetic Variance Detection : Technologies for Pharmacogenomics (Nuts & Bolts series) (Nuts & Bolts series)

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Genetic Variance Detection : Technologies for Pharmacogenomics (Nuts & Bolts series) (Nuts & Bolts series)

Manufacturer: DNA Press
ProductGroup: Book
Binding: Paperback

Biochemistry | Biological Sciences | Science | Subjects | Books

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ASIN: 0974876550

Product Description

This comprehensive reference for novice students and experienced scientists studying DNA in organisms compares and evaluates the technological choices available in detecting genetic variances in pharmacogenomics. Commonly used technologies such as sequencing, DNA array and chip technologies, mass spectrometry, gel- and chromatography-based technologies, as well as less commonly used methods are described in detail and illustrated with specific examples. Expert advice is presented on technological options to facilitate decisions about the utility and applicability of individual technologies for specific needs.

Chemical Mutagens. Principles and methods for their detection. Volume 4

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Chemical Mutagens. Principles and methods for their detection. Volume 4

Manufacturer: Plenum Pub Corp
ProductGroup: Book
Binding: Hardcover

Genetics | Evolution | Science | Subjects | Books
ASIN: 0306371049

Laboratory Methods for the Detection of Mutations and Polymorphisms in DNA

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Laboratory Methods for the Detection of Mutations and Polymorphisms in DNA
Graham R. Taylor
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

Biochemistry | Biological Sciences | Science | Subjects | Books

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ASIN: 0849392330

Book Description

The analysis of DNA sequence polymorphisms and mutations is of central importance in understanding biological systems. This book is devoted to the experimental analysis of DNA and presents easy-to-follow protocols. Various techniques from the simple to the highly complex are detailed in this volume, providing a wide spectrum of available methods and practical advice. The methods are described in terms of: · History and background · Principles and theory · Equipment and reagents · Protocols · Troubleshooting · Applications · Improvements · Results · Comparisons with other methods · Future prospects and developments This is an essential manual for researchers working in human, animal, or plant molecular genetics and is particularly valuable for hospital and commercial laboratories.

Laboratory Protocols for Mutation Detection

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Laboratory Protocols for Mutation Detection

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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Book Description

Random mutagenesis and gene knockout experiments are standard techniques to investigate the effects of specific genetic factors. In recent years, improved methods for mutation analysis have greatly simplified the study of natural mutations and sequence variants to learn more about the function
of our genetic makeup, and to predict and finely diagnose disease. Accordingly, mutation analysis is assuming a rapidly increasing importance in academic, clinical, and industrial research. This collection of protocols for mutation detection techniques arose as a set of formulas shared among
participants at a HUGO-sponsored workshop held in Visby in 1995, where an impressive list of originators and major users of mutation detection methods gathered to exchange experiences. The techniques included span a wide range of areas; some are currently in use, while others illustrate principles
that may be of importance in future test formats.

Molecular Genetic Epidemiology - A Laboratory Perspective (Principles and Practice)

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Molecular Genetic Epidemiology - A Laboratory Perspective (Principles and Practice)

Manufacturer: Springer
ProductGroup: Book
Binding: Paperback

Biochemistry | Biological Sciences | Science | Subjects | Books

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ASIN: 3540413871

Book Description

This volume describes high-throughput approaches to a series of robust, established methodologies in molecular genetic studies of population samples. Such developments have been essential not only to linkage and association studies of single-gene and complex traits in humans, animals and plants, but also to the characterisation of clone banks, for example in mapping of genomes. Chapters have been written by developers or highly experienced end-users concerned with a diverse array of biological applications. The book should appeal to any researcher for whom costs and throughput in their genetics laboratory have become an issue.

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Mutation Detection
Richard G. H. Cotton
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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Book Description

Cancer and the mechanisms of its development are receiving increasing research interest. New genes are being isolated almost daily, Fundamental to those studies is the ability to detect mutations. Mutation detection is time consuming and expensive and thus should be undertaken with a thorough
knowledge of the alternative methods. This book aims to critically review the field, refer to methodology and protocols, and give illustrative examples as well as put the whole emerging field in context, including ethical considerations.

Mutation Detection: A Practical Approach

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Mutation Detection: A Practical Approach

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

Genetics | Evolution | Science | Subjects | Books

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Book Description

Although important in a great many fields, mutation detection is both time-consuming and expensive. This volume offers the latest tried and tested protocols for a range of detection methods, from the labs of the leading researchers in the field.

PCR Mutation Detection Protocols (Methods in Molecular Biology)

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PCR Mutation Detection Protocols (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Paperback

Genetics | Evolution | Science | Subjects | Books

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ASIN: 0896036170

Book Description

1Bimal D. Theophilus and Ralph Rapley provide biological and clinical investigators with a comprehensive collection of new, recent, and updated PCR-based screening methods suitable for detecting the presence of both known and novel mutations. The methods cover point mutations (e.g., ASO-PCR, SSCP, DGGE, chemical cleavage), deletions (multiplex PCR, FISH, blotting), non-sense mutations (PTT), and more. The new and exciting techniques of DNA array analysis, along with such recently developed experimental methods as conformation-sensitive gel electrophoresis, are also included. Each chapter explains the basic theory behind the technique and provides valuable notes essential for its successful execution.

Polymorphism Detection & Analysis Techniques

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Polymorphism Detection & Analysis Techniques

Manufacturer: Eaton Publishing Company/Biotechniques Books
ProductGroup: Book
Binding: Paperback

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Book Description

The author introduces the statistical analysis of geophysical time series. The book includes also a chapter with an introduction to geostatistics, many examples and exercises which help the reader to work with typical problems. More complex derivations are provided in appendix-like supplements to each chapter. Readers are assumed to have a basic grounding in statistics and analysis. The reader is invited to learn actively from genuine geophysical data. He has to consider the applicability of statistical methods, to propose, estimate, evaluate and compare statistical models, and to draw conclusions.

The author focuses on the conceptual understanding. The example time series and the exercises lead the reader to explore the meaning of concepts such as the estimation of the linear time series (AMRA) models or spectra.

This book is also a guide to using "R" for the statistical analysis of time series. "R" is a powerful environment for the statistical and graphical analysis of data."R" is available under GNU conditions.

Book Description

This is the first reference on amorphous silicon and polycrystalline silicon thin film transistors that gives a systematic global review of all major topics in the field. These volumes include sections on basic materials and substrates properties, fundamental device physics, critical fabrication processes (structures, a-Si:H, dielectric, metallization, catalytic CVD), and existing and new applications. The chapters are written by leading researchers who have extensive experience with reputed track records. Thin Film Transistors provides practical information on preparing individual functional a-Si:H TFTs and poly-Si TFTs as well as large-area TFT arrays. Also covered are basic theories on the a-Si:H TFT operations and unique material characteristics. Readers are also exposed to a wide range of existing and new applications in industries.

Book Description

These 5 stories engagingly reveal Poe's virtuoso gifts for both crime detection and the macabre. Includes 2 of his most famous tales, "The Mystery of Marie Roget" and "The Purloined Letter," which introduces C. Auguste Dupin, the first fictional detective. Also features "William Wilson," a chilling tale of crime and evil.

Customer Reviews:

convenient and well-priced (supliment advised).......2002-07-25

This little Dover edition is cheap and fits easily into any bag, which makes it good bus stop reading. There is, however, a disadvantage to this portable Poe; namely, it's not all there. The collection excludes the story for which Poe is credited for having begun the detective genre itself: "The Murders in the Rue Morgue" introduces the characters of Dupin and our narrator, and prepares the scene for the detective figure to fill the gap of reasoning that the overly-methodical Parisian police have left. It sets the tone for the increased emphasis on analysis in "Marie Rogêt" and the humorous rivalry between police and detective in "The Purloined Letter." That being said, the other stories fit well together; "The Oblong Box" has one foot in the detective genre and the other in that species of psychological drama that we see in "William Wilson." Wilson and his doppelganger compliment the double corpse question in "Marie Rogêt," and the parallel worlds and coincidences, which make the mystery of Marie Rogêt more fascinating, lend an uncanny quality to "MS Found in a Bottle," with the discovery of Mercator's map. If these stories show us anything about Poe, it is his ability to bring a story to a logical conclusion that still leaves an eerie taste in the reader's mouth.

Another winner from the library of Poe..........2000-03-28

As always Edgar Allan Poe has created a masterpiece with this work, just as he has done with all his others. He makes haunting, chilling, and tingling stories come to life like nightmares during the daytime. He was a true master of suspense and storytelling and this work is no exception. If you enjoyed any of his others, like The Tell-tale Heart or The Raven, then you'll be sure to enjoy these tales of terror and detection.

Classic short stories.......2000-03-24

Edgar allen poe is one of the greatest short story writers I have ever had the pleasure to read. His stories are varied and extremely intelligent. And at the cheap price this collection of stories are a must buy. I give it an extra star just for the price.

The Great Fog: Wierd Tales of Terror and Detection

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The Great Fog: Wierd Tales of Terror and Detection
H.F. Heard
Manufacturer: Sun Dial Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000MU6FTS

The Great Fog: Weird Tales of Terror and Detection

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The Great Fog: Weird Tales of Terror and Detection
Gerald Heard
Manufacturer: The Vanguard Press
ProductGroup: Book
Binding: Hardcover

United States | Short Stories | Literature & Fiction | Subjects | Books

Short Stories | Science Fiction | Science Fiction & Fantasy | Subjects | Books
ASIN: B0007DPE9C

Poe's Children: Connections between Tales of Terror and Detection

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Poe's Children: Connections between Tales of Terror and Detection
Tony Magistrale , and Sidney Poger
Manufacturer: Peter Lang Publishing
ProductGroup: Book
Binding: Paperback

Classics | General | Literature & Fiction | Subjects | Books

Literary | General | Literature & Fiction | Subjects | Books
ASIN: 0820440701

Book Description

This study traces Edgar Allan Poe's contribution to the Gothic tradition and his invention of the detective tale. It explores the connections between these genres in British and American writers influenced by Poe, such as Arthur Conan Doyle, Robert Louis Stevenson, Thomas Harris, and Stephen King. This book also examines women writers strongly influenced by Poe, such as Joyce Carol Oates, Sara Paretsky, and Sue Grafton. The last chapter of the volume considers films--in particular, the Roger Corman Poe series, Chinatown, Seven, and Blade Runner--that connect the horror and detective genres.

Weird Tales of Terror and Detection, the Great Fog

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Weird Tales of Terror and Detection, the Great Fog
H. F. Heard
Manufacturer: The Sun Dial Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000GVIGUE

WEIRD TALES OF TERROR AND DETECTION: The Great Fog; The Crayfish; Wingless Victory; Despair Deferred; The Swap; Dromenon; The Cat I Am; The Rousing of Mr. Bradegar

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WEIRD TALES OF TERROR AND DETECTION: The Great Fog; The Crayfish; Wingless Victory; Despair Deferred; The Swap; Dromenon; The Cat I Am; The Rousing of Mr. Bradegar
H. F. Heard
Manufacturer: Sun Dial Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000GVXS4S

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TALES OF TERROR AND DETECTION
Edgar Allan Poe
Manufacturer: Dover Publications, Inc.
ProductGroup: Book
Binding: Paperback

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Tales Of Terror And Detection
Edgar Allan Poe
Manufacturer: NY
ProductGroup: Book
Binding: Paperback

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