Chiral Separation Techniques: A Practical Approach

Book Description

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

Capillary Electrophoresis in Chiral Analysis

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Capillary Electrophoresis in Chiral Analysis
Bezhan Chankvetadze
Manufacturer: Wiley
ProductGroup: Book
Binding: Hardcover

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Capillary Electrophoresis in Chiral Analysis Bezhan Chankvetadze Tbilisi State University, Republic of Georgia The application of capillary electrophoresis (CE) to the field of chiral analysis has exploded recently. The advantages of capillary electrophoresis - extremely high peak efficiency, excellent compatibility with biological samples, short analysis time, simplicity, versatility and low cost - are perfect for the accurate measurement of optical purity, increasingly important in the regulation-ruled pharmaceutical industry. Although there have been a number of books on capillary electrophoresis and chiral analysis separately, as yet there has been no dedicated monograph on the application of capillary electrophoresis to chiral analysis. This book bridges the gap. Capillary Electrophoresis in Chiral Analysis charts the evolution of chiral capillary electrophoresis and describes new types of chiral selectors and mechanistic aspects of chiral recognition. While on the one hand, it is an excellent introduction to newcomers, on the other, it is of practical use to experienced researchers in the field wishing to solve a particular separation problem. It includes an alphabetical list of chiral compounds resolved using CE with appropriate references, which any one working in the field will find invaluable.

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Chiral Chromatography
Thomas E. Beesley , and Raymond P. W. Scott
Manufacturer: Wiley
ProductGroup: Book
Binding: Hardcover

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Book Description

Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P. W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, pharmaceutical and clinical laboratories. The Wiley Separation Science Series provides the analyst in these laboratories with well-focused books covering individual techniques, so that they can be applied more efficiently and effectively to contemporary analytical problems. The different enantiomers of a drug can exhibit widely different physiological activity in degree and nature. As a result, the separation and identification of enantiomers is now a very important analytical problem and chiral chromatography is the natural technique to apply to the resolution of such mixtures. Chiral Chromatography provides the reader with a basic understanding of the nature of chromatographic separations and relates the principles specifically to the separation of enantiomers. The following information is included:
* chiral separations involving both gas and liquid chromatography
* descriptions of the apparatus used for both techniques
* detailed discussion on the retention mechanism that results in chiral selectivity
* the structure and synthesis of a wide range of chirally active stationary phases used in both gas and liquid chromatography
* preparative applications for large scale purification of enantiomers
* applications of capillary electrophoresis and capillary electrochromatography.
In addition to the above, a large number of examples of the separation of both commercially and physiologically interesting chiral mixtures are given, as is a detailed discussion on the mechanism of selectivity of each example. Thomas Beesley was founder and is the CEO for a leading manufacturer of chiral stationary phases and has published papers on TLC, HPLC and chiral separations involving cyclodextrins. He has also coauthored papers with Daniel W. Armstrong, an expert on modern cyclodextrin columns. Raymond Scott has worked in the field of separation science for over 40 years and has contributed extensively to the development of both gas and liquid chromatography publishing over 160 papers on the subjects.

Chiral Pollutants: Distribution, Toxicity and Analysis by Chromatography and Capillary Electrophoresis

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Chiral Pollutants: Distribution, Toxicity and Analysis by Chromatography and Capillary Electrophoresis
Imran Ali , and Hassan Y. Aboul-Enein
Manufacturer: Wiley
ProductGroup: Book
Binding: Hardcover

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Book Description

Today, among the various chiral discrimination methods, chromatography and capillary electrophoresis techniques have become powerful tools in environmental analysis. Therefore, there is a need to describe the art of the determination of the chiral pollutants in the environmental matrices. This book provides the complete information on the types of the chiral pollutants, their toxicities and methods of determination by chromatography and capillary electrophoresis.

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Adam Hart Davis has interviewed some of the most influential scientists and thinkers of our time. In this fascinating insight into modern science he presents the stories behind the science, the difficulties behind the discoveries and the future of the findings, as explained by the people themselves.

Chiral Separations (Chromatographic Society Symposium)

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Chiral Separations (Chromatographic Society Symposium)
D. Stevenson , and I.D. Wilson
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Chiral Separations by Capillary Electrophoresis

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Chiral Separations by Capillary Electrophoresis
Ann Van Eeckhaut , and Yvette Michotte
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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Chiral Separations by Chromatography (American Chemical Society Publication)

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Chiral Separations by Chromatography (American Chemical Society Publication)
Satinder Ahuja
Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover

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ASIN: 0841236313

Book Description

The primary focus of this book is on developing or selecting suitable chromatographic methods for chiral separations. A large number of examples are given to assist in this process, including thin-layer, gas, HPLC, supercritical fluid, capillary electrophoresis, and membrane separations. It provides information on stereochemistry, TLC, GLC, and CE separation methods and detection; explores the importance of preparative separations; and illustrates the stereoisomeric composition of chemical compounds of pharmaceutical significance. There is discussion of regulations and requirements as they apply to the development of pharmaceutical compounds, and a detailed section on HPLC methods.

Chiral Separations by Liquid Chromatography (Acs Symposium Series)

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Chiral Separations by Liquid Chromatography (Acs Symposium Series)

Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover

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ASIN: 0841221162

Book Description

A definitive reference for researchers working on problems involving chirality. Presenting state-of-the-art information, this volume covers all the major modes of separation and offers contributions from the leading researchers who developed these techniques. Four chapters provide a detailed review of the commonly used columns: brush type, cyclodextrin, polysaccaride carbonate, and protein. Many of the papers focus on HPLC, a technique which is also ideally suited for large scale preparation of optical isomers. In addition, the volume provides significant discussion on the use of chiral discriminators or selectors.

Chiral Separations by Liquid Chromatography: Theory and Applications (Chromatographic Science, Vol. 90) (Chromatographic Science)

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Chiral Separations by Liquid Chromatography: Theory and Applications (Chromatographic Science, Vol. 90) (Chromatographic Science)
Hassan Y. Aboul-Enein , and Imran Ali
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 0824740149

Book Description

Unique in its systematic and detailed description of the various types, structures, and properties of chiral stationary phases (CSPs) and their preparation, application, and future scope, this volume highlights an assortment of liquid chromatographic approaches, including sub- and super-critical fluid chromatography, capillary electrochromatography, and thin layer chromatography. Readers will find: · viable optimization techniques for enantiomeric resolution on various types of CSPs · new strategies in liquid chromatography and related technologies of chiral separations · a valuable resource filled with 1200 of the most recent and relevant literature citations

Chiral Separations: Applications and Technology (ACS Professional Reference Books)

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Chiral Separations: Applications and Technology (ACS Professional Reference Books)

Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover

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Book Description

Chronicles the theory and practical applications of chiral technology by focusing on the efficient preparation, isolation, and separation of chiral molecules in optically pure forms. Discusses asymmetric synthesis and chiral resolution in a variety of contexts, including enantioselective reactions and additions, enzyme-catalyzed reactions, chromatographic methods with various chiral stationary phases or chiral discriminators, and enantioselective membrane transport.

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Demonstrates how a basic knowledge of chaos theory can be used to evaluate chaotic experimental time series data and how to apply the presence of chaos to achieve practical goals. After familiarizing the reader with fundamental concepts of chaos, the text introduces the important topics of dimension, symbolic dynamics, Lyapunov exponents and entropy. Contains extensive reprints from major papers on the subject and concludes with a research bibliography of articles directed toward coping with chaos.

Coping with Chaos: Analysis of Chaotic Data and the Exploitation of Chaotic Systems. (book reviews): An article from: IIE Transactions

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Coping with Chaos: Analysis of Chaotic Data and the Exploitation of Chaotic Systems. (book reviews): An article from: IIE Transactions
Abhijit V. Deshmukh
Manufacturer: Institute of Industrial Engineers, Inc. (IIE)
ProductGroup: Book
Binding: Digital

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This digital document is an article from IIE Transactions, published by Institute of Industrial Engineers, Inc. (IIE) on June 1, 1996. The length of the article is 881 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Coping with Chaos: Analysis of Chaotic Data and the Exploitation of Chaotic Systems. (book reviews)
Author: Abhijit V. Deshmukh
Publication: IIE Transactions (Refereed)
Date: June 1, 1996
Publisher: Institute of Industrial Engineers, Inc. (IIE)
Volume: v28 Issue: n6 Page: p527(2)

Article Type: Book Review

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Coping with Chaos: Analysis of Chaotic Data and the Exploitation of Chaotic Systems

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Coping with Chaos: Analysis of Chaotic Data and the Exploitation of Chaotic Systems
Edward Ott
Manufacturer: Wiley, John & Sons, Incorporated
ProductGroup: Book
Binding: Paperback
ASIN: B000MV4YMC

Book Description

For decades, anthropologist Hill Gates had waited for an opportunity to get to know the citizens of China as she had done in Taiwan--face to face, over an extended period of time. At last in the late 1980s she set out on an excursion to Sichuan Province. That visit was the first of many she would make there on a remarkable double adventure: to gain a deeper understanding of Chinese women and to complete a difficult passage in her own life. Looking for Chengdu is her memoir of these trips. By turns analytic, witty, and bittersweet, Gates's observations on contemporary China are enlivened by a keen eye for the oddities of human behavior, including her own.

The vast, inland province of Sichuan was the birthplace of the Chinese economic reforms of the 1970s, and is now speeding from the sixteenth to the twenty-first century. Was its economic boom transforming women's lives, Gates wondered? After a generation of socialist rule, would women risk the challenge of entrepreneurship? A feminist, she was especially curious to learn what Chinese of both sexes defined as women's rights.

Gates traveled--by boat, train, bus, car, bicycle, and foot (her preference)--across the spectacular countryside, gleaning insight into China's massive bureaucracies from her experiences on an obligatory vacation, in a Tibetan dance-hall, and at a shouting match in her Chengdu home. She met dozens of hard-working, stylish women running family firms, and crossed paths with scholars and sailors. Her book is rich in anecdotes and compelling moments, from her journey through mountain villages in search of five thousand women with bound feet to low-voiced conversations about the Chengdu equivalent of the events at Tiananmen Square.

A fascinating glimpse into the deeply personal vocation of anthropology, Gates's memoir will change the way readers think about the Chinese people.

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A view of Chinese womenýs entrepreneurial spirit.......2004-05-26

This book is a memoir of a decade past written following a Rockerfeller grant to study the women's emancipation movement in SW PRChina, to later compare and contrast with a similar study in Taipei, Taiwan. This fieldwork is undertaken with the cooperation of the Propaganda Dept, Women's Federation, Chengdu, Szechwan province, PRChina.

Structurally this book is a daily diary which covers, in part, her travels in China as well as some highlights of 100 interviews on women-owned, small business entrepreneurs, that were formed during the Deng's Reform and Opening campaign of the late 80s.

Her POE is Guangzhou, where she decides to initially travel alone much as the natives do. Her travel scenarios, including her visit to Kunming, City of Eternal Spring, in the first 50 pages of the book, where she had local academic acquaintances to show her the sights. She speaks Putonghua, a form of Mandarin, so she can slowly communicate with the locals in a basic form. It appears that she does not like reading Chinese. In part, she writes with the older Wade-Giles form of romanization, so Szechwan is Sichuan and Taipei is Taibei. Armed with an Academy letter, she uses it to travel, as best she can to cajole the ticket sellers and hostel and guesthouse desks, the way the natives do, and cites prices in RMB, and FEC only when there is no other alternative or she wishes to splurge with a hot bath.

The more memorable scenarios is her visit to Kunming, capital of the mountainous Yunnan province p36-44 in December 1988. They travel up the Burma Road a bit and discuss the minority people and their distinctive dress p54-8. She eats the native food and promptly gets a bad case of diarrhea, spends two days in bed. She buys a beautiful Naxi cape from a leather maker that was destined to be another bride's dowry.

Halfway through her anthropological project, her tired workgroup of four demands that she take vacation and unknownst to her, her host department arranged a 7-day holiday with a drive and excursion into far Western Szechwan province to enjoy the Fall colors and stay with a Tibetan family p109-138. Anticipating a boring trip and getting behind in her project, she crankily accompanies the group during another PMS episode. Contrary to her expectation, she enjoys the trip immensely, romps in the forest, and sees blue sky. At each stop, there are local Women's Federation reps to show the group around and introduce them to native families, translate discussions, and describe what they are seeing. They discuss the Tibetan-Han dichotomy and how each culture tries to co-exist.

There are about 20 scenarios on interviews on women-owned businesses in the book. Most businesses are small, from mom & pop format to ones with handfuls of employees. They are the stereotypical grocery, restaurant, garment, and etc format. What I got out of the book was that women's survival during the "Great Leap Forward" and Cultural Revolution was very harsh, especially in the countryside. Initially the Politburo encouraged formation of these businesses, the owners used the profits to improve their houses, and then the tax collectors came to even things out in the socialist's tradition. So the Politburo is inventing their policies at time goes. It seeds flourishing entrepreneur until they become successful, then taxes them for an increased revenue stream.

Her writing is fairly well crafted and she discusses scenarios of general interest, so that one can finish the book without getting truly bored of repetitious fieldwork details. The book, divided into 19 chapters, includes about 20 photos of subjects, maps and travel itineries to follow along. There is no index and any notes are referenced on the bottom of the page. Comparatively, I would consider her prose better and more comprehensive than Paul Theroux, a China travel writer covering the same time period. But Peter Hessler is a better describer of Chinese thought and behavior; of course he spent 2 years at a teachers college and learned the local dialect. But as indicated in the preface, she notes her literary limits and includes her published bibliography of academic work.

The author is a Canadian born, UK raised and educated, who writes in UK prose, so you have to decipher the usual suspects that differ in UK vs US English. She earns her doctorate at Central Michigan U, but is at heart a Brit feminist, and constantly refers to it during her sojourn. From time to time this divorced, pre-menopausal woman titillates the reader with her fantasies as a ravishing redhead in China. To me this was pulp-fiction that the editors must have required her to put in the scripts to help sales. I could have also done without the monthly PMS issues.

She keeps contemporaneous notes on her notebook computer, so hopefully 10 years later, she doesn't over embellish or forget the details of her 6 month sojourn in Chengdu. I read this book at a local library.

She attempts to unify her prose by introducing a historical mentor that went before her, a fellow Brit, Ms Isabella Bird Bishop, who does China research in Szechwan a century earlier. Since she merely references her work in a couple pages p48-9, I find it rather distracting, yet amused that she compared her journey to hers.

on the absurdity of Amazon reviews.......2004-02-15

Yes, I have read some of Gates' work, but not this one - it doesn't matter in this system. I am merely balancing a double counting of a positive textual review that registers numerically as a zero, thus artificially generating a very low average.
On balance Amazon reviews are useful, but the lack of control leads to this sort of nonsense. Note also the lack of signature on the doubled review; presumably just an error but one wonders given the recent Canadian site boondoggle with these reviews.

Observing the transition from Maoism on the ground.......2002-09-04

Perhaps a third of the book is about traveling in China, mostly in southwestern China, where private enterprise blossomed during the 1980s. The other two thirds are about trying to do research funded by the Rockefeller Foundation, sponsored and administered by the Sichuan Fulian (Women's Federation--literally "Women United"). Anthropologists' fieldwork memoirs are published after more academic presentation of their research results--in Gates's case, a 1997 book _China's Motor: A Thousand Years of Petty Capitalism_ (that compares what she observed in the 1970s in Taiwan, historical records, and her 1987-96 research in Sichuan). The discomforts, including sickness, depression, frustrations about transportation, food, lodging, access to information, and the misunderstanding by "the natives" of the anthropologist's wisdom and good-will may not be vented in public at all.

Although the author is the major character in the account of her research in the years before and after the crackdown of the PRC gernotacry on private consumption and the accumulation of riches by anyone other than the families of high-placed officials, unlike much contemporary postmodernist anthropology, Gates remains interested in the agency of people (particularly women) trying to prosper in changing and difficult conditions in societies organized differently than the anthropologists' own one. Gates is engagingly honest about her frustrations with Chinese life as well as her joys of solidarity with those she studied and the reader learns some things about living through rapid change in the Chinese interior from her insightful book.

What We're Looking For When We're Looking for Chengdu.......2000-08-01

I lived in Japan for 9 years and this is a book I want to give friends who ask what it was like. Even though this book is about China, and China and Japan are not the same thing, reading this book helped me to understand much about what I had seen and been through in my own experience. Yes! Yes! Yes! I kept saying when I read it. This is how it was. And here is somebody putting it into words.

There are the underlying truths about Asia, and greater yet underlying truths about crossing between any two cultures. Finally, there are the truths about any woman's life whether she stays home or travels far. Hill Gates calls them as we all have seen them, from getting your period to getting your hair cut in a foreign land. There are the long van rides that constitute "vacations," the forced alcohol, the question of breakfast foods, unheated living quarters, unexplained prohibitions, glorious discoveries of beautiful scenery, and the eternal question of whether being a foreigner means you're also actually a woman.

But most of all, it's about the work. In this case, the work is anthropology. Here again, universal truths apply. Good work gives you an adequate struggle. You want to solve things, you want to apply your own talents. You want to learn and contribute, get and give, laugh and cry. Really, you do. You hope to be changed by it and come back with something to report. You enjoy sinking into the luxuries and comforts of your own familiar culture once you make it back to dry land. And then, one day down the road, you get that hankering to leave those comforts again...What a privilege having this life is. All it costs is the belief that you have control over anything.

My favorite quote from the book ought to warn off anyone who thinks you get to control your own dignity once you choose to put yourself out there. Gates nails it as she observes that, "When it comes to etiquette, the home team has the advantage."

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