DNA Methylation Microarrays: Experimental Design and Statistical Analysis

Book Description

Written from the perspective of an analyst who interacts closely with biology colleagues who have only minimal knowledge of statistics and programming, DNA Methylation Microarrays provides a solid understanding of methodological foundations and enables critical thinking for advanced studies. Using graphics to illustrate the results, the book presents examples based on real biological data from a variety of cellular samples with array hybridizations performed in the laboratory. It covers quality control, experimental design, normalization, significant differential methylation, clustering, dependence networks, and online annotations.

DNA Methylation Protocols (Methods in Molecular Biology)

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DNA Methylation Protocols (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0896036189

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DNA Methylation Protocols offer a set of readily reproducible protocols of the analysis of DNA methylation and methylases. These powerful methods provide the tools necessary for studying methylation at both the global level and the level of sequence, and include many techniques for identifying genes that might be aberrantly methylated in cancer and aging. Additional methods cover genome-wide analysis of abnormal DNA methylation and the isolation and measurement of demethylases and related proteins.

DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment)

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DNA Methylation, Epigenetics and Metastasis (Cancer Metastasis - Biology and Treatment)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 1402036418

Book Description

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.

DNA Methylation: Approaches and Applications

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DNA Methylation: Approaches and Applications

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 084932050X

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A guide to understanding the complex regulatory roles of DNA methylation, this volume describes the relation that this biological mechanism has to gene silencing in disease and explores its promising role in treating cancer. DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its promising role in treating cancer. The author considers research, clinical, and industry perspectives in this growing field, and by synthesizing previously scattered literature, he offers the subject's first organized and cohesive resource and bibliography. The book is a state-of-the-art reference for understanding the role DNA methylation plays in human disease, particularly cancer. Written by leaders in the field, this exceptional compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation status of genomic DNA. It includes concepts, experimental models, and clinical uses of demethylating agents. The book provides a balance between articles clarifying methodological details and more general review chapters that offer broad biological perspectives on DNA methylation. Covering fundamental theory, technologies, and applications, DNA Methylation: Approaches Methods, and Applications presents the most current research on using DNA methylation to decipher the pathways involved in human disease. This is an invaluable handbook for researchers and clinicians interested in genetics and molecular biology, particularly epigenetic therapies and gene silencing.

DNA Methylation: Biochemisty and Biological Significance (Springer Series in Molecular Biology)

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DNA Methylation: Biochemisty and Biological Significance (Springer Series in Molecular Biology)
Aharon Razin , and Howard Cedar
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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DNA Methylation: Molecular Biology and Biological Significance (Experientia Supplementum)

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DNA Methylation: Molecular Biology and Biological Significance (Experientia Supplementum)
J. Jost , and H. Saluz
Manufacturer: Birkhauser
ProductGroup: Book
Binding: Hardcover

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ASIN: 3764327782

Epigenetic Mechanisms of Gene Regulation (Cold Spring Harbor Monograph Series)

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Epigenetic Mechanisms of Gene Regulation (Cold Spring Harbor Monograph Series)

Manufacturer: Cold Spring Harbor Laboratory Press
ProductGroup: Book
Binding: Hardcover

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Epigenetics - No. 214
Novartis Foundation Symposium
Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Hardcover

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Book Description

Epigenetic phenomena are increasingly recognized as having significant economic and medical relevance. For instance, certain human disease syndromes may be due to the inheritance of paternal-specific patterns of gene activity that are largely independent of DNA sequence. This book both assesses our current understanding of the molecular mechanisms that direct epigenetic phenomena, and discusses how future work should not only provide solutions for biotechnologists and medical researchers who are seeking to express genes, but should also uncover new and so far unexplored areas of molecular and cell biology. The authors use our extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting levels at which genes can be regulated. They discuss the role of chromosomal domains in gene silencing, the parameters that determine the activity of transgenes in plants and animals, the host defence mechanisms that protect organisms from the danger of integrating foreign DNA into their chromosome, and the importance of genomic imprinting in development and human disease.

Molecular Biology of DNA Methylation (Springer Series in Molecular Biology)

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Molecular Biology of DNA Methylation (Springer Series in Molecular Biology)
Roger L. P. Adams , and Roy H. Burdon
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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DNA Methylation

Manufacturer: Springer Verlag
ProductGroup: Book
Binding: Hardcover
ASIN: 3540960384

Book Description

The dramatic advances in the efficiency of digital computers during the past decade have provided hydrologists with a powerful tool for numerical modeling of groundwater systems. Introduction to Groundwater Modeling presents a broad, comprehensive overview of the fundamental concepts and applications of computerized groundwater modeling.
The book covers both finite difference and finite element methods and includes practical sample programs that demonstrate theoretical points described in the text. Each chapter is followed by problems, notes, and references to additional information. This volume will be indispensable to students in introductory groundwater modeling courses as well as to groundwater professionals wishing to gain a complete introduction to this vital subject.

Key Features
* Systematic exposition of the basic ideas and results of Hilbert space theory and functional analysis
* Great variety of applications that are not available in comparable books
* Different approach to the Lebesgue integral, which makes the theory easier, more intuitive, and more accessible to undergraduate students

Customer Reviews:

Introduction to Groundwater Modeling.......2003-05-05

I found this text very valuable in explaining the differences between these two methods and how each handles the dependent variable (head) and its first derivative (flow). The text also discusses Laplaces equation, iterative methods including Gauss-Seidel/SOR. Chapters are dedicated to finite difference and finite element methods under steady-state and transient conditions. It also demonstrates how each element is handled separately using finite element method and then the equations are assembled into a conductance matrix.

This text is a very good complement to other modeling texts. However, if you want to learn how to set up your hydrogeologic conceptual model, what data is needed to develop a good model, how to choose your numerical model, verify, calibrate your model, interpret results and perform a post audit, this is not that text. For the purpose of model setup etc. I would recommend Applied Groundwater Modeling.

Outdated and of little value.......2001-12-09

I found this book somewhat outdated. Even though it was well-written if was of little value. There are several other books of better quality.

Highly recommended.......2000-03-31

I've used this book in two of my groundwater modeling classes. Despite the fact that it is a little outdated, it has the clearest explaination I've come across of the mathematics behind groundwater modeling. In addition, it contains very good example problems.

Book Description

The present textbook on nuclear structure takes a unique and complementary approach compared to existing texts on the topic. Avoiding complicated calculations and complex mathematical formalism, it explains nuclear structure by building on a few elementary physical ideas. Even such apparently intricate topics as shell model residual interactions, the Nilsson model, and the RPA analysis of collective vibrations are explained in a simple, intuitive way so that predictions can usually be made without calculations, essentially by inspection. Frequent comparison with data allows the relevance of theoretical approaches to be immediately evident. This edition includes new chapters on exotic nuclei and radioactive beams, and on correlations of collective observables. Completely new discussions are given of isospin, the shell model, nature of collective vibrations, multi-phonon states, superdeformation, bandmixing, geometric collective model, fermi gas model, basic properties of simple nuclear potentials, the deuteron, etc. With the amount of new material this new edition is essentially a new book.

Customer Reviews:

My advisor Dr. Mark A. Riley was right!.......2007-02-13

My PhD. advisor, Dr. Mark A. Riley, "strongly suggested" this book to me and he was right to do so. Dr. Casten's discussion of nuclear structure phenomina has been pivotal to my understanding of this topic. The field of nuclear structure can at first seem quite impenetrable but the manner in which Dr. Casten discusses this topic has made it much more accessible than many other texts that I have read. I consider it one of the most treasured books used in my nuclear physics education.

Warren T. Cluff
Graduate Student
Nuclear Physics Group
Florida State University

My students love this book!.......2006-06-30

This is a truly wonderful introductory text for anyone interested in or performing work in the domain of "low energy" nuclear physics. I strongly suggest (I don't like to insist) that my PhD students read closely through Dr. Casten's superb and insightful explanations concerning the magnificent variety of phenomena exhibited by the atomic nucleus. Without exception, ever since the first edition was published in 1990, my students have loved Casten's approach. They have even been known en-masse to "put their money where their mouth is" and have gone out and actually bought this book just so they can have their own copy always close at hand. It really is that good and that useful to them! Need one say more?

Dr. Mark Riley
Raymond K. Sheline Professor of Physics
Nuclear Physics Group
Florida State University

Nuclear Structure from a Simple Perspective (Oxford Studies in Nuclear Physics)

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Nuclear Structure from a Simple Perspective (Oxford Studies in Nuclear Physics)
R. F. Casten
Manufacturer: Oxford University Press
ProductGroup: Book
Binding: Paperback
ASIN: B000OJZ7GE

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Nuclear Structure from a Simple Perspective (Oxford Studies in Nuclear Physics)
R. F. Casten
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback
ASIN: B000OKXM88

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