Chemical Genomics: Small Molecule Probes to Study Cellular Function (Ernst Schering Research Foundation Workshop)

Book Description

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Book Description

This revised text presents a cogent explanation of the fundamentals of meteorology, and explains storm dynamics for weather-oriented meteorologists. It discusses climate dynamics and the implications posed for global change. The Fourth Edition features a CD-ROM with MATLAB® exercises and updated treatments of several key topics. Much of the material is based on a two-term course for seniors majoring in atmospheric sciences.

* Provides clear physical explanations of key dynamical principles
* Contains a wealth of illustrations to elucidate text and equations, plus end-of-chapter problems
* Holton is one of the leading authorities in contemporary meteorology, and well known for his clear writing style
* Instructor's Manual available to adopters

NEW IN THIS EDITION
* A CD-ROM with MATLAB® exercises and demonstrations
* Updated treatments on climate dynamics, tropical meteorology, middle atmosphere dynamics, and numerical prediction

Customer Reviews:

Extraordinarily good text.......2007-03-08

I have to say I'm not sure if texts on atmospheric dynamics get better than this. Physics books in general, in fact, rarely provide an understanding of phenomena that is so concise, intuitive, and yet mathematically robust. I highly recommend it for children, as a gift, and for pleasure reading.

I also very seriously recommend it as a graduate textbook. Five stars all the way.

feedback from rmd.......2007-01-19

it's a very analytic book; it's strongly related to anaysis. all the models are very well explaned; perhaps there is not a good relationship between models and pratical meteorology. phenomena are quite 'hidden' by equations, and only a good experienced physicist has the tools to extract the pratical approach deriving from model behaviours.
however it remains a 'must' for meteorologists.

Renato Medini

The most exellent textbook in dynamics of the atmopshere.......2007-01-18

This book, in my opinion, is the most valuable book on dynamical aspects of the atmosphere insofar, especially from pedagogical point of views. As a foreign student, I understand well Holton's writings. Simple but very concise sentences, no wordy explanations. The first 3 chapters provide you the basic equations used in meteorology and their common approximations. The next 5 chapters, to me, are the most interesting chapters. They give you wide range of knowledge from boundary layer, synoptic scale phenomena, to instabilities. Equations are of great usefulness because THEY bring into the light physical contents of the dynamics of the atmosphere. To me, any analytical equation and its explicit solution provide us a more complete understanding than numerical models do (because you never know some unpredictable behaviour of numerical solutions). So, try to understand carefully the simplest cases that Holton selected. This gives you a lot of deeper understandings. Chapters 9 to 11 provide the dynamics of meso- to large-scale circulations. You will see why the Hadley circulation descends around 35N in very clear way. However, simple Poisson eqn with the argument of "positive forcing, negative solution" that is applied throughout the text should be paid especial attention because this conclusion is not always true. As a whole, the contents, explanations and derivations will be very well constructed if you see the main point of each section.
To get to the heart of this book, read and derive all the skips in Holton's derivations. The gaps are not too hard to fill out in math but require some thinking. DO ALL OF THE EXERCISES at the end by yourself and you will double your knowledge. For any math-related physical book, transparent derivations are the first thing you should figure out, physical explanations will follow subsequently. From my experience, people tend to skip any chapter what they thought they knew it already. If you apply this method here, you may be in trouble. Read carefully the first 5 chapters, understand approximations used in the each situation. Simply apply equations without judgments of their assumptions will take you into the nightmare.

I give this book 5 stars +. It is really classic....

you can't find an alternative........2006-03-15

when i was a student, i used to think, like many other reviewers, that the book is extremely dry. but now as a researcher in atmospheric-oceanic dynamics, i realise that the book is useful in explaining the most essential and elementary theories behind the dynamics one can encounter in meteorology or climate dynamics.

use the book as a reference and revision of elementary concepts. if you encounter a process you need to understand in your research, this is the book which will tell you the basics. then you go on and learn more from journal articles and your own research.

this new edition of the book, especially with the matlab models, makes studying with it more fun because you can visualise the dynamics and play with the m-files yourself.

An Underrated Text.......2003-10-01

This book, often simply referred to as "Holton", has been roundly cursed by undergraduates since it was first published. I know, because I was one of them. However, as the years went by, and as the number of classes requiring Holton as a text went by, I realized two things. First, that this book was not meant to hold your hand through all the derivations. It requires a competent instructor who can use Holton as a detailed companion to rigorous coursework. This book is NOT for the average person who wishes to study alone. The second thing is that this book was written to fill a gap. There were no similar atmospheric dynamics texts. As a consequence, it must cover a large amount of material in a rather small, college textbook-sized space. It does this well. Yes, the author's writing style is dry to the extreme, and yes, physical explanations are often lacking. However, if you have access to a competent professor, neither of these are problems. One final thought... as we call the book simply "Holton" remember that Frankenstein's monster is often called simply "Frankenstein", but we will leave comparisons to the reader - and to the author!

Customer Reviews:

Very well written.......2002-02-16

As a modern textbook in the theory of relativity, this book is rare, in that its goal is to give the reader a conceptual introduction to the theory, and not just mathematical formalism. The author also does not hesitate to include some philosophical argumentation wherever needed. It is written for the advanced undergraduate, and will prepare such a reader for more advanced reading in the subject.

The first chapter of the book is the best, for it is a comprehensive discussion of the origins of the theory of relativity as one that rejected the assertion that space and time were absolute. The author also gives an interesting historical discussion of Lorentz's ether theory, wherein Lorentz hypothesized that bodies moving through the ether undergo a contraction, and he discovered a time transformation that implied that clocks moving through the ether run slow. As the author points out, Lorentz thought such considerations were purely mathematical, and not important physically. In addition, in the section on Mach's principle, the author discusses briefly the work of Dennis Sciama who showed that the 1872 gravitational theory of F. Tisserand included Mach's principle. I was not aware of this work, and it motivated me to do further reading on the subject. The author also gives several examples to show that Mach's principle is not physically vacuous, but has observational consequences.

Chapter two overviews the kinematic consequences of the special theory of relativity. The most interesting part of this discussion was the section on the formulation of special relativity without assuming the invariance of the speed of light. The author shows that the principle of relativity implies that either all inertial frames are related by Galilean transformations, or all are related by Lorentz transformations with the same (postive) velocity (squared).

A discussion of optical effects follows in chapter 3. One unexpected and interesting result in this chapter is that a moving sphere has a circular outline to all observers because of length contraction.

Some of the mathematical formalism needed in special relativity is overviewed in chapter four. The class of four-vectors and four-tensors is defined, and the light cone geometry discussed in detail.

The relativistic mechanics of point particles is covered in chapter five. Such a theory is cast in the language of four-vectors, and the author explains nicely the mass-energy equivalence, analyzes scattering from a relativistic standpoint in the center of momentum frame, and shows how Newtonian mechanics is altered in the relativistic realm. He also spends a little time on relativistic continuum mechanics, via the energy tensor of the simplest continua: dust.

The connection between relativity and electrodynamics is outlined in chapter six. The material is standard and found in most books on relativity.

The author begins the study of general relativity in chapter seven with some elementary considerations of the differential geometry of curved surfaces and also Riemannian spaces. The author endeavors, rightfully, to explain the mathematics in a way that is intuitive as possible, rather than hitting the reader with highly abstract formalism.

He then presents the mathematica foundations of general relativity in chapter eight. After a brief review of tensor calculus, the author considers the gravitational field equations in a vacuum, emphasizing their nonlinearity. This is followed by a detailed discussion of the famous Schwarzschild solution. In addition, he considers a particular exact solution of the Einstein field equations in a vacuum, namely a plane-fronted gravitational wave. Although not physical, this solution illustrates some important properties of general gravitational radiation.

The author ends the book with a fairly detailed overview of cosmology. The difficulties in the pre-relativistic cosmology are discussed, one of the more interesting being the consideration of the Newtonian gravitational field inside a cavity resulting from the removal of a finite sphere from a static universe. Recognizing that Poisson's equation does not have a constant solution led to the alteration of the Newtonian potential and thus a modification of the Poisson equation. As the author observes, this move to get a static Newtonian universe is formally the same as what Einstein did via the introduction of the cosmological constant in his field equations (also to get a static universe). The author also considers the Robertson-Walker, Milne, and Friedman universe, and compares these to what is known observationally.

Relativity in the style of Feynman's Lectures.......1998-07-19

This is a wonderful book, very amusing and thought provoking. Without trying to be comprehensive, it sheds much light on the basics of the theory, as well as of the mathematics. His discussion of Mach's principle is brilliant, and ends with a proposal of an experiment to test it with satellites! Very good at computations too, boasting tables for computing the curvature tensor from the metric tensor which are very useful.

subtle approach to SR and GR.......1997-07-15

Although not the most comprehesive text on the subject (see Thorne's tome, Gravitation), Essential Relativity is perhaps the most fulfilling book from which to learn both special and general relativity on a graduate school level. Flipping through the pages, one cannot help but notice that it often reads like a novel. For the student or the adventurous, a wide variety of problems are found in an appendix. The author's background in differential geometry is very evident in his excellent explanations of difficult concepts.

Cosmological Relativity: The Special and General Theories of the Structure of the Universe

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Cosmological Relativity: The Special and General Theories of the Structure of the Universe
Moshe Carmeli
Manufacturer: World Scientific Publishing Company
ProductGroup: Book
Binding: Hardcover

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ASIN: 9812700757

Relativity: Special, General, and Cosmological

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One of the worst text on GR
Whoosh
Very good

Relativity: Special, General, and Cosmological
Wolfgang Rindler
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0198567316

Book Description

Relativistic cosmology has in recent years become one of the most exciting and active branches of current research. In conference after conference the view is expressed that cosmology today is where particle physics was forty years ago, with major discoveries just waiting to happen. Also
gravitational wave detectors, presently under construction or in the testing phase, promise to open up an entirely novel field of physics.

It is to take into account such recent developments, as well as to improve the basic text, that this second edition has been undertaken. The most affected is the last part on cosmology, but there are smaller additions, corrections, and additional exercises throughout.

The books basic purpose is to make relativity come alive conceptually. Hence the emphasis on the foundations and the logical subtleties rather than on the mathematics or the detailed experiments per se. Aided by some 300 exercises, the book promotes a deep understanding and the confidence to tackle
any fundamental relativistic problem.

Customer Reviews:

One of the worst text on GR.......2005-06-19

This is one of the worst text I came across. Author keep discussing a topic but never points to the result. A book where you keep flipping back and forth to make sense. Often notations are used but there is no explanation what they represents. I have gone through chapter 15 and 18 ,on Linearized GR and FRW metric, following every step and found out that there are few errors and a lot of key steps are omitted. For example, gauge transformations are done and results are obtained but if you won't consult other similar texts then you won't know what are the results and which are the transformations, unless you already are a professor. Almost same topic is discussed in Inverno's book and you can clearly see what are the various transformations and what are the results.

A book may contain every topic what you are looking for but the key Qs is how well are they conveyed. In order to write an excellent text the author should be first clear about it in his own mind and organize it before publishing it. Save yourself and get a nicer book like Inverno or Stephani. I would not recommend this text for GR unless absolutely necessary.

Whoosh.......2003-05-01

Professor Rindler explains the concepts with clarity and rigour while minimising the complexities of the notation and formulae. His ability to put ideas into words is outstanding. If you have heard the tales of trains that whoosh past in the ether, and are still none the wiser; or have wondered how the background radiation that set out on its way at the speed of light when the world was a smaller simpler place is only now reaching us, this book will enlighten you. Even for those whose maths cannot keep up it should be worthwhile, stimulating even, to read the sections at the beginning of each chapter, and those elsewhere light in formulae. For those willing to tackle the exercises he is perhaps a little too generous with the hints.

Very good.......2002-12-27

I think both undergraduates and graduates students in physics will find this text enjoyable and enlightening. The sections on general relativity and cosmology are, I think, a little less thorough and complicated than those in Wald or Shultz, though I've only briefly perused those other texts. (GR is still plenty abstract and mathematical in Rindler.) The end of chapter exercises are well-chosen and lead the reader to understand the material. Rindler does an excellent job of keep physical insight at the forefront of his discussions. He points out and resolves a number of interesting paradoxes, and he mentions a number of interesting modern experiments when relevant.

Cosmological Special Relativity: The Large-Scale Structure of Space, Time and Velocity, Second Edition

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Cosmological Special Relativity: The Large-Scale Structure of Space, Time and Velocity, Second Edition
Moshe Carmeli
Manufacturer: World Scientific Publishing Company
ProductGroup: Book
Binding: Hardcover

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ASIN: 9810249365

Book Description

This book presents Einstein's theory of space and time in detail, and describes the large-scale structure of space, time and velocity as a new cosmological special relativity. A cosmological Lorentz-like transformation, which relates events at different cosmic times, is derived and applied. A new law of addition of cosmic times is obtained, and the inflation of the space at the early universe is derived, both from the cosmological transformation. The relationship between cosmic velocity, acceleration and distances is given. In the appendices gravitation is added in the form of a cosmological general relativity theory and a five-dimensional unified theory of space, time and velocity. This book is of interest to cosmologists, astrophysicists, theoretical physicists, mathematical physicists and mathematicians.

Essential Relativity: Special, General, and Cosmological

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Essential Relativity: Special, General, and Cosmological
Wolfgang Rindler
Manufacturer: Springer
ProductGroup: Book
Binding: Paperback
ASIN: B000PGJE60

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ESSENTIAL RELATIVITY (SPECIAL,GENERAL,AND COSMOLOGICAL)
WOLFGANG RINDLER
ProductGroup: Book
Binding: Hardcover
ASIN: B000U081CO

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Essential Relativity: Special, General, and Cosmological
Wolfgang Rindler
Manufacturer: Van Nostrand
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Binding: Hardcover
ASIN: B000VNK39O

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Relativity (Special, General and Cosmological)
Wolfgang Rindler
Manufacturer: Oxford University Press(UK)
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Binding: Paperback
ASIN: B000OKY8YK

RELATIVITY: SPECIAL GENERAL & COSMOLOGICAL

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RELATIVITY: SPECIAL GENERAL & COSMOLOGICAL
RINDLER
Manufacturer: Oxford University Press, USA
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Binding: Paperback
ASIN: B000OL2YFE

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Man Without a Country and Other Great Stories, The
Edward Everett Hale
Manufacturer: SPENCER PRESS
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Binding: Hardcover
ASIN: B000K07LQQ

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The Man Without a Country & Other Stories (Classics Library (NTC))
Edward Everett Hale
Manufacturer: NTC/Contemporary Publishing Company
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ASIN: 1853265586

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The Man Without A Country and Other Patriotic Stories
Edward Everett, Illustrated by R. Pallen Coleman, J. L. G. Ferris and Earl K. Bergey Hale
Manufacturer: Phila.: The John C. Winston Co. 1925
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ASIN: B000GVHTHA

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Man Without a Country & Other Stories
Francis R Gemme
Manufacturer: AIRMONT PUBLISHING CO INC
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ASIN: B000VUMF7A

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The Man Without a Country and Other Great Stories (Clear Type Series)
Edward Everett Hale
Manufacturer: Clear Type Publishing Committee
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Binding: Hardcover
ASIN: B000L2NMSY

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The Man Without a Country and Other Great Stories (in Original box)
Edward Everett Hale
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ASIN: B000K0D03E

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The Man Without a Country and Other Patriotic Stories
John M Foote
Manufacturer: John C Winston
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ASIN: B000L2FZT8

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The Man Without a Country and Other Patriotic Stories
John M. Foote
Manufacturer: John C. Winston
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THE MAN WITHOUT A COUNTRY AND OTHER STORIES
Edward Everett Hale
Manufacturer: Little brown and Company
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ASIN: B000QAEO9C

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The Man Without a Country and Other Stories

Manufacturer: Airmont Publishing Company
ProductGroup: Book
Binding: Paperback
ASIN: B000ENL6FQ

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This book includes the following stories: 1) The man without a country, 2) The Gift of the Magi 3) The Purloined Letter 4) The Man that Corrupted Hadleyburg, 5) The great Stone face and 6) Love of Life

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