Molecular Mechanisms of Neurodegenerative Diseases (Contemporary Clinical Neuroscience)

Book Description

Marie-Françoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Neurodegenerative Disorders: Mechanisms and Prospects for Therapy (Dahlem Workshop Reports)

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Neurodegenerative Disorders: Mechanisms and Prospects for Therapy (Dahlem Workshop Reports)
D. L. Price , H. Thoenen , and Albert J. Aguayo
Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Paperback

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Book Description

Dahlem Workshop Reports Life Sciences Research Report 51 Neurodegenerative Disorders Mechanisms and Prospects for Therapy Edited by D.L. Price, H. Thoenen and A.J. Aguayo Neurological disorders, particularly the neurodegenerative diseases involving the central nervous system, are characterized by dysfunction and death of specific populations of nerve cells. Cellular and molecular neurobiological strategies have begun to clarify the mechanisms of neuronal degeneration and have led to the design of new approaches to prevent cell degeneration, promote cell survival, and restore the functions of diseased nerve cells. This book provides new information concerning these processes. Background papers review exciting new developments concerning: (a) the mechanisms of neuronal degeneration caused by genetic factors, excitotoxins, and calcium; (b) the molecular pathology leading to abnormalities in Alzheimer's disease and the spongiform encephalopathies or prion diseases; (c) the biological substrates of cell differentiation, axon guidance, and target recognition during development, repair, and recovery; and (d) the potential therapeutic efficacies of growth factors and grafted cells in re-establishing circuits essential for the restoration of function. The group discussions and background papers in this Dahlem Workshop Report communicate both the excitement and enthusiasm of the participants facing the scientific challenges that are part of this important area of neurobiological research. This volume will be of special interest to professionals in the fields of molecular/cell biology, genetics, neuroanatomy, neurochemistry, developmental neurobiology, and neuropathology as well as clinicians working in neurology and psychiatry. Goal of this Dahlem Workshop: to understand the molecular and cellular mechanisms of neurological disease and to explore new approaches to treatment.

Neurodegenerative Diseases : Molecular and Cellular Mechanisms and Therapeutic Advances

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Neurodegenerative Diseases : Molecular and Cellular Mechanisms and Therapeutic Advances
No Author
Manufacturer: Springer
ProductGroup: Book
Binding: Paperback
ASIN: B000OSMJ7A

Book Description

This text is intended for undergraduate and beginning graduate students in chemistry and biochemistry studying amino acids and peptides. The authors concentrate on amino acids and peptides without detailed discussions of proteins, while giving all the essential background chemistry, including sequence determination, synthesis and spectroscopic methods. The approach is intended to encourage the reader to cross classical boundaries while gaining an understanding of protein behavior on a molecular level. The book includes chapters on the biological roles of amino acids, as well as a section on enzyme-catalyzed synthesis of peptides, with suitable examples, an area often neglected in texts describing peptide synthesis. This modern text will be of value in the amino acid, peptide and protein field, to advanced undergraduates, graduate students and research workers.

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This text is suitable for advanced undergraduate and beginning graduate students in chemistry and biochemistry studying amino acids and peptides. The authors concentrate on amino acids and peptides without detailed discussions of proteins, although the book gives all the essential background chemistry, including sequence determination, synthesis and spectroscopic methods, to enable the reader to appreciate protein behaviour at the molecular level. The approach is intended to encourage the reader to cross classical boundaries, as in the later chapters on the biological roles of amino acids and the design of peptide-based drugs. For example, there is a section on the enzyme-catalysed synthesis of peptides, with suitable examples, an area often neglected in texts describing peptide synthesis. This modern text will be of value in the amino acid, peptide and protein field, to advanced undergraduates, graduate students and research workers.

Amino Acid and Peptide Synthesis (Oxford Chemistry Primers, 7)

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A book for student to understand basic idea about peptide synthesis.

Amino Acid and Peptide Synthesis (Oxford Chemistry Primers, 7)
John Jones
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0199257388

Book Description

The study of amino acids and peptides is becoming increasingly important to chemists becuase of the growing overlap of mainstream organic chemistry with bioorganic chemistry and biochemistry. This introductory text begins with a brief survey of the role and diversity of amino acids, peptides, and proteins in nature, and goes on to describe and explain the principal methods of chemical synthesis. With its emphasis on chemical principles and strategies rather than detailed technical matters, the book will be essential reading for all students of chemistry and biochemistry with an interest in this important field. This second edition contains extensive additions and adjustments, to present a completely up-to-date account of the chemical essentials of mainstream peptide synthesis.

Customer Reviews:

A book for student to understand basic idea about peptide synthesis........2007-01-05

This is a good for a text book. It can help you to understand basic chemistry of peptide synthesis. It doesn't tell you the detail procedure about how to synthesis peptide. You have to buy some books such as "Fmoc-peptide synthesis" if you are really working on peptide synthesis and need step-by-step procedures for synthesizing different type of peptides.

Practical Guide to Protein and Peptide Purification for Microsequencing

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Practical Guide to Protein and Peptide Purification for Microsequencing

Manufacturer: Academic Press
ProductGroup: Book
Binding: Plastic Comb

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ASIN: 0124802826

Book Description

Why a Second Edition?
The Second Edition provides practical answers to the general question, "How can I obtain useful sequence information from my protein or peptide?" rather than the more specific question asked in the first edition, "How can I obtain the N-terminal sequence?" Important new methods include ways of dealing with blocked N termini, computer analysis of protein sequences, and the recent revolution in mass spectrometry.

Key Features
Highlights of the Second Edition:
* Mass spectrophotometric characterization of proteins and peptides
* N-terminal sequencing of proteins with blocked N termini
* Internal amino acid sequence analysis after protease digestion in-gel and on-blot
* Improved microscale peptide purification methods
* Computer analysis of protein sequences
* New protocols tested and refined through everyday use in authors' laboratories
* Updated reference chapter covering all aspects of protein microsequencing

Peptidomimetics Protocols (Methods in Molecular Medicine)

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Peptidomimetics Protocols (Methods in Molecular Medicine)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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Book Description

A state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. Topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed.

Proteins, amino acids and peptides as ions and dipolar ions (American Chemical Society. Monograph series)

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Proteins, amino acids and peptides as ions and dipolar ions (American Chemical Society. Monograph series)
Edwin Joseph Cohn
Manufacturer: Reinhold Pub. Corp
ProductGroup: Book
Binding: Unknown Binding

Amino Acid Biosynthesis Pathways, Regulation and Metabolic Engineering (Microbiology Monographs)

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Amino Acid Biosynthesis Pathways, Regulation and Metabolic Engineering (Microbiology Monographs)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 3540485953

Book Description

Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch.

The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives. Comprehensive reviews are given of recent achievements to enable or improve production of amino acids and dipeptides by fermentation and enzyme catalysis. Here, the particular focus is on metabolic engineering, the rational improvement of metabolic functions using recombinant DNA technology.

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Amino acids (Peptides)

Manufacturer: Georg Thieme Verlag
ProductGroup: Book
Binding: Paperback

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Amino Acids and Peptides

Manufacturer: Royal Society of Chemistry
ProductGroup: Book
Binding: Hardcover

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Amino Acids and Peptides (Chapman and Hall Chemistry Sourcebooks Series)

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Amino Acids and Peptides (Chapman and Hall Chemistry Sourcebooks Series)
J. S. Davies
Manufacturer: Chapman & Hall
ProductGroup: Book
Binding: Paperback

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Amino Acids and Peptides, Vol. 17 (Amino Acids and Peptides)

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Amino Acids and Peptides, Vol. 17 (Amino Acids and Peptides)

Manufacturer: Royal Society of Chemistry
ProductGroup: Book
Binding: Hardcover

Book Description

This book is aimed at graduate students in physics who are studying group theory and its application to physics. It contains a short explanation of the fundamental knowledge and method, and the fundamental exercises for the method, as well as some important conclusions in group theory.

The book can be used by graduate students and young researchers in physics, especially theoretical physics. It is also suitable for some graduate students in theoretical chemistry.

Book Description

From one of the most innovative writers of the 20th century — a splendid collection displaying the author's lively imagination and delicate style. Includes "A Haunted House," "A Society," "An Unwritten Novel," "The String Quartet," "Blue & Green," "Kew Gardens," "The Mark on the Wall," and the title story.

Customer Reviews:

Eight challenging pieces by a master prose stylist.......2003-04-04

"Monday or Tuesday: Eight Stories," by Virginia Woolf, is an intriguing collection that holds up to re-readings. The copyright page of the Dover Thrift edition notes that the book is an unabridged republication of the edition published in 1921.

In many of these stories conventional notions of plot and character are apparently thrown out the window in favor of a dreamlike, experimental style. At times the stories in this book remind me of the work of Gertrude Stein. Woolf crafts some really memorable phrases and visual images.

The longest of the 8 stories, "A Society" (pp. 3-16) is about a group of women who form a "society for asking questions" about male contributions to the world. This piece has a rich satirical flavor; in it Woolf raises questions about female creativity and procreativity, the nature of fiction, and the impact of female literary artists.

Although at times I often found Woolf's writing obscure, I enjoyed her elegant prose style.

Classic Woolf.......2001-08-08

This volume of short stories is a good re-introduction to an author most of us probably haven't seen since High School. The stories are engaging and thought-provoking, and the length is manageable even to someone out of practice with the stream of conciousness style. I carried this book to read between classes one semester and enjoyed the challenge of reading something better than standard leisure fare. This book made me want to see more Virginia Woolf. Well recommended.

Monday or Tuesday: Eight Stories.......2000-05-26

This book of eight stories by Virginia Woolf shows Virginia's mind at work demonstrating her "stream of consciousness." Each story flows from one thought to another asking different questions about life. For example, "The Mark on the Wall" questions the meaning of life and existence. "An Unwritten Novel" is about what people hide and what you don't know about a person you seat next to on an "omnibus." All these stories will make you look at life in a slightly different way.

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Monday Or Tuesday Eight Stories
Dover Virginia Woolf
Manufacturer: NY
ProductGroup: Book
Binding: Paperback
ASIN: B000MUAKZ8

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