Colony Stimulating Factors: Molecular and Cellular Biology (Immunology Series, Vol 49)

Book Description

Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.

Cytokines and Colony Stimulating Factors: Methods and Protocols (Methods in Molecular Biology)

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Cytokines and Colony Stimulating Factors: Methods and Protocols (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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Book Description

Hands-on laboratory experts describe for the novice investigator a host of novel technologies and molecular techniques specifically designed to study cellular immunology and promote its gene therapy applications. Presented in step-by-step detail to ensure ready reproducibility, these protocols range from flow cytometric techniques to detect cytokines and growth factors in different specimens, to methods for generating and expanding dendritic cells and hematopoietic progenitors from different origins. Although the protocols require little previous experience, even highly skilled researchers will augment their skills with many novel timesaving techniques.

Granulocyte Responses to Cytokines (Immunology Series)

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Granulocyte Responses to Cytokines (Immunology Series)
R. G. Coffey
Manufacturer: Informa Healthcare
ProductGroup: Book
Binding: Hardcover

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Book Description

This volume explores the basic physiological functions of granulocytes, their modification by cytokines, and the clinical experience with cytokines - discussing the specific responses of neutrophils, eosinophils, basophils, and mast cells to individual cytokines.;Written by more than 60 experts from all over the world, Granulocyte Responses to Cytokines ...: examines the responses of granulocytes and mast cells to hormones, chemotactic peptides, and phorbol esters; details cytokine effects on morphology, micration, adhesion, phagocytosis, degranulation, and cytotoxicity against tumour cells and pathogens; covers cyclic nucleotide, protein kinases, G proteins, lipoxygenase, and leukotrienes in the regulation of granulocyte functions; indicates caution in the use of cytokine therapy for certain leukaemias due to cytokine effects on the growth of malignant cells; and presents clinical studies with granulocyte-macrophage and granulocyte colony-stimulating factors with promising results in treating genetic, virus-, and drug-induced granulocytopenias and immunodeficiencies.;Containing nearly 3900 literature citations, Granulocyte Responses to Cytokines is a guide for immunologists; hematologists; oncologists; pharmacologists; biologists, microbiologists, and biochemists; pathologists; internists; and graduate-level students in these disciplines.

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Haemopoietic Colony Stimulating Factors
Donald Metcalf
Manufacturer: Elsevier
ProductGroup: Book
Binding: Hardcover

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ASIN: 0444805648

The Hemopoietic Colony-stimulating Factors: From Biology to Clinical Applications

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The Hemopoietic Colony-stimulating Factors: From Biology to Clinical Applications
Donald Metcalf , and Nicos Anthony Nicola
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0521034817

Book Description

The colony-stimulating factors (CSFs) are the major regulators in the body of the production and activity of two types of white blood cells--granulocytes and macrophages. CSFs are used by clinicians to treat patients with damaged immune systems, for example, as a result of chemotherapy. This book provides a detailed and up-to-date account of the discovery of the CSFs, their structure, molecular biology and cellular receptors, the biology of the CSFs in vivo and in vitro, and their present and future clinical applications. Written by two of the pioneers in the discovery of CSFs, it is a clear and well illustrated survey of the history, current knowledge and future directions of this exciting field of investigation, and serves also as a guide to the more general areas of growth factor and cytokine research. It will prove an invaluable review for cell biologists interested in how growth factors act on the body, as well as for clinicians applying the fruits of modern biotechnology to improved patient care.

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Manual of Gm-Csf

Manufacturer: Blackwell Science Inc
ProductGroup: Book
Binding: Hardcover

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The Molecular Basis of Cellular Defence Mechanisms - Symposium No. 204

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The Molecular Basis of Cellular Defence Mechanisms - Symposium No. 204
CIBA Foundation Symposium
Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Hardcover

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ASIN: 0471965677

Book Description

Much of the defence of the body against invading microorganisms has been delegated to two sets of haemopoietic cells—the T and B lymphoid cells, and the granulocytes and monocyte/macrophages. These have in common their ancestral origin from multipotential haemopoietic stem cells and the need to be produced continuously throughout life. This biology requires complex programmes of controlled cell division, differentiation, commitment and maturation, the molecular nature of which have been established in some detail. While there are unique features of the regulations of each of the four lineages, there is much in common in the manner in which corresponding processes are controlled by a group of interacting regulatory glycoproteins. Based largely on the use of clonal in vitro cultures, the regulators involved have been cloned and active recombinant regulators mass-produced. The membrane receptor complexes mediating the cellular actions of these regulators have been identified and at least some details of the intracellular signalling pathways established. In the case of the granulocyte-macrophage regulators, the colony stimulating factors (CSFs), successful documentation of their effectiveness in enhancing host resistance to model infections has led to their widespread clinical use. However, the biology of the regulatory process indicates that these regulators are designed to operate in combination. The availability of more than twenty of these regulators in mass-produced recombinant form offers exciting prospects for their use in appropriate combinations for intelligent clinical intervention in diseases ranging from infections to cancer, provided only that the daunting logistical problem posed by current testing requirements can be resolved. In parallel to these exciting developments, the enormously large and fertile field of lymphokine research has grown up. Whereas the molecular regulators of haemopoiesis, the CSFs, come generally within the purview of haematologists, the lymphokines are the `property of the immunologists. Despite the conceptual similarities in the two fields, and despite the fact that CSFs have actions on the immune system and some interleukins have actions of haemopoiesis, meetings where experts from the two fields get together are still very rare. This book contains the detailed discussions of a group of experts from both fields.

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The Molecular Control of Blood Cells
Donald Metcalf
Manufacturer: Harvard University Press
ProductGroup: Book
Binding: Hardcover

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Are erythropoietin and growth factors useful adjuncts to hepatitis C therapy?(Pro & Con): An article from: Family Practice News

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Are erythropoietin and growth factors useful adjuncts to hepatitis C therapy?(Pro & Con): An article from: Family Practice News

Manufacturer: International Medical News Group
ProductGroup: Book
Binding: Digital

Hepatitis | Disorders & Diseases | Health, Mind & Body | Subjects | Books
ASIN: B00082DPCU
Release Date: 2005-07-31

Book Description

This digital document is an article from Family Practice News, published by International Medical News Group on March 15, 2004. The length of the article is 826 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Are erythropoietin and growth factors useful adjuncts to hepatitis C therapy?(Pro & Con)
Publication: Family Practice News (Magazine/Journal)
Date: March 15, 2004
Publisher: International Medical News Group
Volume: 34 Issue: 6 Page: 20(1)

Distributed by Thomson Gale

Cancer therapy, supportive: An entry from Thomson Gale's
<i>Gale Encyclopedia of Nursing and Allied Health</i>

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Cancer therapy, supportive: An entry from Thomson Gale's Gale Encyclopedia of Nursing and Allied Health
Deanna M., R.N. Swartout-Corbeil
Manufacturer: Thomson Gale
ProductGroup: Book
Binding: Digital

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Book Description

The “Gale Encyclopedia of Nursing and Allied Health” is an alphabetically arranged five-volume set of more than 850 entries written for students and professionals in the field. Topics include body systems and functions, conditions and common diseases, issues and theories, techniques and practices, and devices and equipment. The Encyclopedia covers all major health professions, including nursing, physical therapy, occupational therapy, respiratory therapy, medical lab technology, emergency medical technology, dental assistance, pharmacology and nutrition, and features appendices of related organizations, agencies and associations.

Book Description

The newest volume in the prestigious series The Chemistry of Heterocyclic Compounds, this work covers synthesis, reactions, properties, structure, physical chemistry and utility of monocyclic azepines.

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Caprolactam
Harold C Ries
Manufacturer: SRI International, Menlo Park 94025
ProductGroup: Book
Binding: Unknown Binding
ASIN: B0007GPQL0

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Caprolactam: Supplement A
Harold C Ries
Manufacturer: SRI International, Menlo Park 94025
ProductGroup: Book
Binding: Unknown Binding
ASIN: B0007GPRGO

Hazard assessment of rice herbicides molinate and thiobencarb to larval and juvenile striped bass (Administrative report / Environmental Resources Division)

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Hazard assessment of rice herbicides molinate and thiobencarb to larval and juvenile striped bass (Administrative report / Environmental Resources Division)
G. A Faggella
Manufacturer: State of California, Resources Agency, Dept. of Fish and Game
ProductGroup: Book
Binding: Unknown Binding

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Nylon 6 and caprolactam
Yu-Ren Chin
Manufacturer: SRI International, Menlo Park 94025
ProductGroup: Book
Binding: Unknown Binding
ASIN: B00071DQC6

Book Description

As John Waller shows in Einstein's Luck, many of our greatest scientists were less than honest about their experimental data. Some were not above using friends in high places to help get their ideas accepted. And some owe their immortality not to any unique discovery but to a combination of
astonishing effrontery and their skills as self-promoters.
Here is a catalog of myths debunked and icons shattered. We discover that Louis Pasteur was not above suppressing "awkward" data when it didn't support the case he was making. Joseph Lister, hailed as the father of modern surgery because he advocated sanitary conditions, was just one of many
physicians who advocated cleaner hospitals--and in fact, Lister's operating room and hospital was far more unsanitary than most. We also learn that Arthur Eddington's famous experiment that "proved" Einstein's theory of relativity was fudged (Eddington threw out two-thirds of his data, 16
photographic plates that seemed to support Newton over Einstein). And while it is true that Alexander Fleming discovered penicillin by lucky accident, he played almost no role in the years of effort to convert penicillin into a usable drug. But once the miracle drug was finally available, the press
hailed him as the genius behind the drug, in part because his story made good copy and in part because war-torn Britain needed a hero (and the other researchers were not British).
Einstein's Luck restores to science its complex personalities, bitter rivalries, and intense human dramas which until recently have been hidden behind myths and misconceptions. This richly entertaining book will transform the way we think about science and scientists.

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A monument to the unknown scientist.......2005-09-18

By showing the truth behind some of the most famous discoveries in the history of science, John Waller pays a tribute to the countless unknown hardworking people who made these discoveries possible. In this well-documented and highly entertaining book, the reader is repeatedly shown that: 1) science seldom progresses through the sudden insights of geniuses, but is a continuous process; 2) as in other fields of human activity, some scientists got a credit they did not deserve, while others were unjustly ignored. This book is a must to everybody who is interested in the history and the ethics of science.

An amazing debunking: our historians, flunking........2005-09-01

John Waller was never born and does not exist: the public has been consistently misled to believe that he wrote a wonderful debunking of some of the greatest stories in scientific history.

This is a scrupulously careful and detailed dismantling and burial of some the oldest fairytales in science. Lister's surgery was filthy and dangerous. Shock! Eddington's observations of the eclipse over West Africa in 1919, which supposedly proved Einstein's theory, were worthless. Horror! The removal of the Broad Street pump probably had no effect on the local cholera epidemic. I'm going to be sick!

It's painful to discover that the guiding stories of one's lifetime are nonsense, but sometimes it just has to be done. This book has done it to me. John, you've broken my heart, but I've come through it stronger and wiser. Alas, I now see the old wives' tales everywhere, so I spend my days shuddering and shaking my head. As the motto of 'The X-Files' put it: Trust No-One.

Interesting and mostly good.......2004-02-21

This book is a refreshing egalitarian change from the kind of history that implies that a handful of geniuses are responsible for most scientific progress. It shows that many famous people were less innovative than is commonly thought, and that science is more incremental than revolutionary (but in spite of the title, it says little about Einstein).
But I can't help wondering whether the book exaggerates to make the misleading histories sound more scandalous than they really were. However, I only see one sentence that seems to justify this suspicion. On page 94 (regarding the effects of the great depression on the Hawthorne studies) he says "the desperation in these words seems to leap from the page". I don't see any clear signs of desperation in those words he quotes. It wouldn't surprise me if the workers were desperate, but the book fails to convince me about this.

My discovery.......2003-08-13

What I like about this book, is that not only is it engaging and a good read, but it actually makes me feel clever!
With interesting stories written in highly accessible language, the author doesn't condescend to his reader nor talk over his head. A true teacher, he reveals, explains and encourages, enticing you to read on first, and then continue to make more discoveries of your own by thinking about the implications of what he says.
Wish we had more authors and teachers out there like this!

illuminating historical insights.......2003-07-31

If this is science history, it's a pity so few professors can write it. This thought-provoking and enjoyable book reads like a series of detective stories while challenging any simplistic assumptions of the past. We learn that some accepted "proofs" proved nothing at all and that we mistakenly label as revolutionaries men who were truly typical of their time.
Dr. Joseph Lister, for examples, whose name is eponymous with antiseptic, managed to exceed the death toll of his colleagues because of his own lack of sanitary standards. Gregor Mendel made important contributions to knowledge but by his own beliefs and theories he was no Mendelian. Charles Darwin followed the tradition of his age in believing in the inheritability of acquired characteristics. And we have pioneers like Robert Millikan and Arthur Eddington who made data fit a chosen theory, rather than the other way around.
Yet, far from belittling such men, this book shows them in a new and more human light that transforms our understanding of scientific discovery. John Waller's book is an entertaining read for the layman and an essential read for the scientist or historian.

A multitude of sins.(History)(Book Review): An article from: American Scientist

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A multitude of sins.(History)(Book Review): An article from: American Scientist
Peter Pesic
Manufacturer: Sigma Xi, The Scientific Research Society
ProductGroup: Book
Binding: Digital

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Einstein's Luck : The Truth Behind Some of the Greatest Scientific Discoveries

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Einstein's Luck : The Truth Behind Some of the Greatest Scientific Discoveries
John Waller
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback
ASIN: B000OLI5VG

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