Atomic Force Microscopy in Cell Biology (Methods in Cell Biology, Volume 68) (Methods in Cell Biology, Volume 68)

Book Description

This is the first book to cover the history, structure, and application of atomic force microscopy in cell biology. Presented in the clear, well-illustrated style of the Methods in Cell Biology series, it introduces the atomic force microscope (AFM) to its readers and enables them to tap the power and scope of this technology to further their own research. A practical laboratory guide for use of the atomic force and photonic force microscopes, it provides updated technology and methods in force spectroscopy. It is also a comprehensive and easy-to-follow practical laboratory guide for the use of the AFM and PFM in biological research.

Atomic Force Microscopy in Cell Biology (Methods in Cell Biology, Volume 68)

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Atomic Force Microscopy in Cell Biology (Methods in Cell Biology, Volume 68)
J. K. Heinrich Horber Bhanu P. Jena
Manufacturer: Academic Press
ProductGroup: Book
Binding: Paperback
ASIN: B000OH1XMS

Book Description

The goal of bioorganic chemistry is to mimic biological processes such as enzyme action, through the synthesis of chemical models with the tools of the organic chemist. This widely-praised textbook is especially suited for the advanced undergraduate or graduate student in chemistry, biochemistry, medicinal chemistry, and pharmacology. The third edition has been substantially revised to reflect new research in the field, and features a major new chapter on self- assembly, auto-organization, and molecular devices. The outstanding figures continue to be a highlight of the book, and were described in an earlier edition as "accurate stereochemical structures...that are the best I've seen for showing the organic chemistry of biomolecules." (Quart. Rev. Biol.)

Bioorganic Chemistry: Volume I, Enzyme Action

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Bioorganic Chemistry: Volume I, Enzyme Action
E. E. van Tamelen
Manufacturer: Academic Press Inc.,U.S.
ProductGroup: Book
Binding: Hardcover

Physiology | Basic Science | Medicine | Subjects | Books
ASIN: 0127143017

The Chemistry of Enzyme Action (New Comprehensive Biochemistry)

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The Chemistry of Enzyme Action (New Comprehensive Biochemistry)

Manufacturer: Elsevier Science Ltd
ProductGroup: Book
Binding: Hardcover

Biochemistry | Basic Science | Medicine | Subjects | Books

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Chemistry of Enzyme Actions 2ND Edition
K George Falk
Manufacturer: CHEMICAL CATALOG CO
ProductGroup: Book
Binding: Hardcover
ASIN: B000QA831W

The chemistry of enzyme actions, (American chemical society. Monograph series)

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The chemistry of enzyme actions, (American chemical society. Monograph series)
Kaufman George Falk
Manufacturer: The Chemical catalog company, inc
ProductGroup: Book
Binding: Unknown Binding
ASIN: B000871S4C

Enzyme Systems that Metabolise Drugs and Other Xenobiotics (Current Toxicology)

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Enzyme Systems that Metabolise Drugs and Other Xenobiotics (Current Toxicology)
Costas Ioannides
Manufacturer: Wiley
ProductGroup: Book
Binding: Hardcover

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ASIN: 0471894664

Book Description

This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:

enzyme function in the metabolism and bioactivation of xenobiotics
substrate specificity
tissue distribution
species distribution (to include laboratory animals and humans)
hormonal regulation
sex differences
modulation by prior exposure to other chemicals
age-dependent expression
pharmacogenetics and modulation by disease.

Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.

Book Description

Enzymes in Action is a timely survey of a modern development in organic chemistry. It is clear that bioreagents demand that organic chemists think in a different way. If they do so, they will open up new avenues of exciting, new chemistry that will permit problems to be solved in an elegant way. The first section covers the concepts necessary to understand enzymes in molecular operations. The second section covers heteroatom enzyme chemistry, with considerable attention being given to the use of enzymes in the detoxification of chemical warfare agents and their application in environmental problems. The final section highlights the strategic use of enzymes in organic chemistry. It is clear that the term `green chemistry' is appropriate, since enzyme mediated processes occur under mild, environmentally benign conditions, and enzymes enable chemists to perform new chemical operations that would otherwise be difficult to achieve at all.

The Enzymes: Chemistry and Mechanism of Action

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The Enzymes: Chemistry and Mechanism of Action

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000GOUFBE

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Maybe Nick Herbert should be a lesion to Joao Magueijo?.......2007-06-10

Faster Than the Speed of Light: The Story of a Scientific SpeculationNick Herbert hadn't heard of Joao Magueijo when he wrote his book and did his research.
But Magueijo didn't have that excuse for not mentioning Nick Herbert?
I give the toss to Nick Herbert as being more open to innovative ideas.
In both cases they could have been more forgiving of our ignorance and given equations...
But it is our way off the Earth to the heavens that is involved here, and Nick Herbert
put material that had to be of use in this research in his book.
The other fellow just didn't. Compare and contrast the two for yourself.

Is time travel possible? This book is food for thought.......2007-02-19

Is time travel possible?

Buried at the heart of this question is perhaps another, more interesting question being: Do we even have the physiological ability to accurately perceive how time passes?

Like the first question, this book provides some interesting food for thought on the second question as well. As has been pointed out by other reviewers, this book from 1988 certainly should not be read alone and to the nominated other suggested works of Brian Greene's Elegant Universe and Fabric of the Cosmos I would also add Lee Smolin's The Trouble with Physics (which questions the efficacy of string theory itself) and also David Darling's Teleportation the impossible leap which is a more recent treatment of the developments relating to using quantum entanglement as potential means for interstellar/instantanious communications.

But back to basics: Do we accurately perceive time?

It's been an incident of scientific progress that great errors occur when natural human insights are imported into scientific theory without the benefit of testing. Two cases in point are the Ptolemaic model of the universe wherein the simple observer assumption that the earth is at the center of the universe and that everything revolves around it is taken as scientific fact and also the Aristetalian dichotemy between body and soul, itself another simple observer assumption that the soul exists independently of the body.

Conversely it's also been an incident of scientific progress that when one is willing to come forward and seriously challenge convention, there is a potential for great scientific advance. Again, citing the Ptolemaic model, the Copernican revolution was seriously revolutionary because it challenged the observer assumption that we alone in the universe were motionless while the rest of creation alone moved. And again, citing the Aristetelian model, the soul/body dichotemy has come under attack based on recent developments in evolutionary psychology which have shown the close correspondence between changes in brain physiology and alterations in human behavior. (If there is a soul then why does the loss some brain cells so radically effect human behavior. See Phantoms in the Brain by V.S. Ramashandran.)

It is in these regards that the question of the human perception of time has had a particular salience and power. And until 1957, no less than Richard Feynman was betting that our perceptions of time were way off. To understand why Feynman made and lost his bet we need to review some basic physics.

There are four fundamental physical forces which govern the universe. Acting at macroscopic scales we have gravitation and electromagnetism. Significantly by 1957 testing had shown that each force was time symetrical. In other words, the processes by which it operated worked the same in forward and reverse. At the microscopic level, the strong nuclear force was also found to be time symetrical.

So when Tsung Dao Lee and Chen Ning Yang decided to test the weak nuclear force, Feynman bet that they would also find this force to be time symetrical according to Steven Pollock, physics professor from University of Colorado at Boulder.

And he lost because the Lee/Yang experiment showed that the weak force was indeed after all not time symetrical which meant that nature indeed after all did have an arrow of time.

Now that having been said, as pointed in this book, there are good reasons to believe that our perception of the speed of the passage of time does vary from the actual physical phenomenon. Likewise, as pointed out by Kurt Vonnegut Jr. in Sirens of Titan and also Slaughterhouse Five there is also a question about why we see time so linearly.

His time traveling Tralfamadoreans saw humans as extended millepeds with baby's feet on one end and geriatric feet on the other and since we exist in all those time frames the question remains as to why we do not similarly experience reality. Like Capernicus questioning the movements of the earth or modern psychology divining the engines of consciousness the question is not a frivolous one but rather, among others provides fodder for scientific discovery.

And now back to the initial question: Is time travel possible?

In this regard, it bears noting that Herbert cleverly titled his book Faster than Light because modern physics does indeed support the movement of faster than light activity at the quantum level. However, like a modern insurance contract, the devil is in the details. This is because mere faster than light travel at the quantum level does not guarantee a basis for human exploitation for time travel purposes.

So at the end of the day, Herbert's book ends up saying what Stephen Hawking says in A brief history of time and what Kip Thorne says in Black Holes and Time Warps...you can't get there from here.

However, like those books this one keys into that very human, very scientific inquiry and asks why not?

A very confusing book.......2004-02-22

The author has clearly misunderstood many basic facts about the theory of special relativity. In fact, it seems that he has combined nearly all popular misunderstandings associated with the speed of light.

One of the most general consequences of Einstein's special relativity from 1905 is that no physical signal (or a piece of matter) can ever move faster than light. The speed of light plays a very important role according to this famous theory. Although a lot of new insights have been accumulated since 1905, the previous sentence remained valid. Einstein discovered general relativity in 1916, and this theory of gravity allows spacetime to become warped - in fact, this theory was found exactly because Einstein knew that Newton's theory of gravity allowed the signals to be sent superluminally, and therefore it contradicted special relativity. Newton's theory could not be quite correct.

Moreover, many physicists have studied various solutions of general relativity that admit the closed time-like curves, i.e. time travels. Although most scientists believe that these solutions are unphysical because of various reasons (such as instability), it is legitimate to study such solutions, and many popular books have been written about these solutions.

Herbert's approach is more primitive. In most of his book, he wants to derive the existence of faster-than-light motion (and time travels, which are then an inevitable consequence) from special relativity itself. One of the main points of special relativity is that exactly this is impossible. There exists a concept of tachyons (from Greek "tachos" which means "speed"), fictitious particles that always move faster than light. Quantum field theory shows that the existence of such particles would also make the Universe unstable because such tachyons could be created in pairs (their energy can be both negative as well as positive). Many of my fellow string theorists revisited the question of tachyons (initially, we would simply eliminate every version of string theory that predicts a tachyon), but all of them agree that the existence of tachyons in the real world would spell doom for the whole Universe. The real goal of the recent calculations involving tachyons in string theory is really to find out the final state of the collapsing Universe (or a membrane floating in the Universe).

Herbert is also confused by the Einstein-Podolsky-Rosen effect in quantum mechanics. He thinks that the entanglement - the correlations between distant objects in the Universe - can be used to send information. No, that's not possible. In his example involving calcium vapors, he does not appreciate that the information comes from the vapor source, not the crystal, and therefore the crystal can't send any usable information. The EPR effect allows correlations between distant objects, but because the outcome of the experiments are random (quantum mechanics only predicts probabilities), there is no way for us to affect the outcome of a faraway experiment i.e. no way to send an e-mail faster than light, for example.

I could continue: he incorrectly interprets the large phase speed of some vibrations in the upper atmosphere, violation of the CP (and T) symmetries by the kaons, and so on. If you want to get the wrong answer to all conceivable questions related to the speed of light, buy this book. If you prefer to learn how the Nature really works, I recommend you a different book. For example "The Fabric of the Cosmos" by Brian Greene explains nearly everything about space and time, including a very entertaining (yet correct) treatment of the Einstein-Podolsky-Rosen effect.

A must-read, with one flaw.......1999-09-17

The author gets high marks for realizing that an acceleration of 1g for 1 year will yield light speed and for analyzing every possible means to break the light speed barrier for both space travel and communications. The book gets four stars instead of five, though, due to a faulty analysis on the communications front. The author makes the intuitive leap that since the Einstein - Podolsky - Rosen experiment reveals the production of two like-polarized photons from the exitation of one calcium vapor atom which can then be detected by calcite crystals at different locations, faster than light communication is possible between the two calcite crystal locations by modulating the crystals themselves. In doing so, he fails to grasp that the signal emanates from the calcium vapor source, not the crystal, and that usuable information can only be fed into the system or changed at the source. The remainder of the book is excellent.

The reader should also be aware that this book was originally written in 1988, and this paperback edition has not been updated to include the ramifications of string theory or M-theory. This book should therefore be followed with "The Elegant Universe" by Brian Greene.

Fabulous Debunking!.......1999-06-29

This is on of the best popularizations I've ever read. Almost every conceivable way to exceed light speed has been debunked here. The author does however leave open tantalizing options that still have some credibility. Read it in three sittings...

Product Description

This is a book to be read by a blazing fire on a winter's night, with the curtains drawn close and the doors securely locked. The unquiet souls of the dead, both as fictional creations and as 'real' apparitions, roam the pages of this haunting new selection of ghost stories by Rex Collings. Some of these stories are classics while others are lesser-known gems unearthed from this vintage era of tales of the supernatural. There are stories from distant lands - Fisher's Ghost by John Lang is set in Australia and A Ghostly Manifestation by 'A Clergyman' is set in Calcutta. In this selection, Sir Walter Scott (a Victorian in spirit if not in fact), keeps company with Edgar Allen Poe, Sheridan Le Fanu and other illustrious masters of the genre.

Customer Reviews:

Some Awesome Ghost Stories From The 1800s.......2007-03-15

Although I bought "Classic Victorian & Edwardian Ghost Stories" thinking it would be more horror-oriented than it turned out to be, the fact that it was different didn't turn out to be a hinderance. What we've got here is a great collection of stories from the 1800s (and perhaps the late 1700s and ealy 1900s as well; it doesn't mention the exact date when each tale was first published) that spans the terrain of mystery, horror, adventure and sometimes even comedy. Among the writers represented are Oscar Wilde, Charles Dickens, M.R. James, Robert Louis Stevenson and Edith Nesbit, among others.

Horror elements are present in such tales as Edgar Allan Poe's famous "The Tell-Tale Heart", the two contributions by Joseph Sheridan Le Fanu ("An Account Of Some Strange Disturbances In Aungier Street" and "Narrative Of A Ghost Of A Hand") and in Edith Nebit's "Man-Size In Marble". This last one is one of the best stories in the book, centering on a newly married couple hard-pressed for cash who find a beautiful and uncommonly affordable country cottage in a beautiful part of the English countryside; and a local superstition involving stone statues. This one's like a great Hammer horror movie.

Charles Dickens presents a pair of stories - "To Be Taken With A Grain Of Salt" (whose title clashes oddly with the eerily believable nature of the story itself), probably one of the earlliest courtoom/ghost crossover stories - and "The Story Of The Bagman's Uncle". As good as "...Grain Of Salt" is, "Bagman's Uncle" is clearly the standout of the two, a delightful and exciting adventure that mixes the mystical and romantic, and the charming and the 'swashbuckling' into one of the best, and most vividly written, short stories I've ever read.

Speaking of delightful, Oscar Wilde's "The Canterville Ghost" starts off as a spooker and crosses over to the realm of comedic fantasy and a tale on the magic of kindness, and meshes all its parts perfectly. Amelia B. Edwards's "The Phantom Coach" is a captivating story about a recluse who is what we'd now term an 'amateur paranormal investigator', I guess, and a stormstayed guest of his. On the sixth page of this one begins an empassioned rebuttal by the recluse against excessive skepticism, that's a true beauty to read. I've been waiting for somebody to put this into words so eloquently, and come to find out, Amelia Edwards did it over a century ago! Another true great in the collection is Robert Louis Stevenson's "Markheim", which carries twists so unexpected - and starts off with hardly a clue as to what its true nature is going to be - that I hesitate to say anything at all about it. One of the more surprising tales I've ever read, this is one it's best to go into with as little foreknowledge as possible.

There are some other good ones, and there are also a few not-so-good. The most unfortunate thing is that several stories - including a couple that could have been much better reads - get marred by ridiculous racist and/or classist elements. These are more common in the earlier-written tales (although certainly not all of the earliest stories in the books are like that!), presumably because such views became less acceptable as the 1800s wore on. There are probably lots of these stories from this era that are far worse than anything presented in "Classic Victorian & Edwardian Ghost Stories" but still, it was a real drag on a couple of the stories.

Overall, though, this is a great collection. It finishes off with several pieces about ghosts that are reportedly true, and in the 'fiction' section of the book it covers a lot of different styles and themes, even having the ghostly elements play only a supporting role in a couple of the stories. A diverse book, with some real gems.

Classic ghost story lovers won't be disappointed.......2003-01-23

I always try to have an anthology of great ghost stories on hand. The table of contents is as different and as full of great stories as the other classic horror anthologies I've already purchased and read. Enjoy.

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VICTORIAN & EDWARDIAN GHOST STORIES

Manufacturer: Barnes & Noble
ProductGroup: Book
Binding: Hardcover
ASIN: 0760703531

Classic Victorian and Edwardian Ghost Stories (Wordsworth Collection)

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Classic Victorian and Edwardian Ghost Stories (Wordsworth Collection)
Rex (editor) Edith Nesbit, Oscar Wilde, Montague Rhodes James, Perceval Landon, Howard Pease, Saki (H.H. Munro), James Hogg, A Clergyman, Edmund Lenthal Swifte, Sir Walter Scott, Richard Barham, R.S. Hawker, Edgar Allan Poe, Elizabeth Gaske Collings
Manufacturer: Wordsworth Editions, Limited
ProductGroup: Book
Binding: Paperback
ASIN: B000P0ZU82

The Mammoth Book of Victorian and Edwardian Ghost Stories (The Mammoth Book Series)

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The Mammoth Book of Victorian and Edwardian Ghost Stories (The Mammoth Book Series)

Manufacturer: Carroll & Graf Publishers
ProductGroup: Book
Binding: Paperback

ASIN: 0786702796

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Victorian and Edwardian Ghost Stories

Manufacturer: Metro Books
ProductGroup: Book
Binding: Hardcover

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