Protein Purification: Design and Scale up of Downstream Processing

Book Description

A comprehensive introduction to the art and science used by the biochemist and process engineer in the design and optimization of large-scale protein-purification processes. Covers the basics of proteins' properties, the unit operations involved in protein purification as well as important related issues of process design, integration with upstream operations, cost and timing to market. Includes an abundance of figures and tables.

Customer Reviews:

An excellent text.......1999-08-04

Scott Wheelwright does an excellent job of bringing together all the diverse problem areas that impact today's downstream processing. This book is one of the "must have's" of the field, and was obviously written with much attention to the myriad of details that are involved in protein purification process development.

Rational Design of Stable Protein Formulations: Theory and Practice (Pharmaceutical Biotechnology)

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Rational Design of Stable Protein Formulations: Theory and Practice (Pharmaceutical Biotechnology)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 0306467410

Book Description

Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view.

This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.

Engineering the Genetic Code: Expanding the Amino Acid Repertoire for the Design of Novel Proteins

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Getting the genetic code to work for us

Engineering the Genetic Code: Expanding the Amino Acid Repertoire for the Design of Novel Proteins
Nediljko Budisa
Manufacturer: Wiley-VCH
ProductGroup: Book
Binding: Hardcover

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ASIN: 3527312439

Book Description

The ability to introduce non-canonical amino acids in vivo has greatly expanded the repertoire of accessible proteins for basic research and biotechnological application.
Here, the different methods and strategies to incorporate new or modified amino acids are explained in detail, including a lot of practical advice for first-time users of this powerful technique.
Novel applications in protein biochemistry, genomics, biotechnology and biomedicine made possible by the expansion of the genetic code are discussed and numerous examples are given.
Essential reading for all molecular life scientists who want to stay ahead in their research.

Customer Reviews:

Getting the genetic code to work for us.......2006-07-14

There was a time around thirty years ago when it all seemed quite straightforward: the genetic code had been fully determined, it was the same in all organisms, and that was that. Understanding initiation still presented some difficulties, but translation and termination apparently presented none. However, few things in biology turn out to be simple: the universal genetic code is now known not to be universal, and gene splicing and other complications have disposed of other aspects of the simple picture.

Realization that the code is not universal may have complicated the textbooks, but it has also provided an opportunity for the biotechnologist: if nature has been able to modify the code then perhaps we can do so as well, and use the built-in protein synthesizing machinery to make proteins with novel aminoacids to fulfil novel functions. To do this successfully, however, we first need to understand the mechanisms that allowed the code to change during evolution. That is what this book, written by one of the world's foremost experts in the field, is about. A large part is devoted to understanding nature, but always with the hope that understanding will bring a capacity to engineer new proteins. It is a mine of information for anyone seriously interested in the subject, and, although perhaps it is a little too detailed for the general reader, it can be read with profit by any biochemist.

In general the biochemical information in the book is sound, though it is a pity that aminoacids are drawn throughout with neutral structures, as one cannot understand their properties without understanding that they are zwitterions. Expert readers will, of course, have no difficulty in reading the structures correctly, but it is not so clear that students will also do so. On page 123 there is the surprising statement that the biosynthesis of histidine is very expensive at about 40 ATP equivalents. The number is correct, but the implication that other aminoacids are much cheaper is not: with the obvious exception of glycine, none of the others is very much cheaper, and nearly half are more expensive, tryptophan being much more expensive.

An unfortunate trend in modern publishing is to save production costs by dispensing with proofreading, or, often amounting to the same thing, putting the whole responsibility on the author. It is neither realistic nor reasonable to expect a Croatian author who has made his career in Germany to detect every error, but it is certainly reasonable to expect a publisher charging around 50 cents a page for the finished product to invest a little of the profits in paying a professional to do the job properly. This, however, seems not have been done, and although most of the errors are minor they appear in great profusion, and include misspellings of numerous names of chemical compounds when it is not always easy to guess what was intended. They have also saved money on the index, which was clearly compiled by someone who had no idea what the book was about, with consecutive entries (leading to the same page) for both "S-phenyl-cys" and "S-phenylcysteine".

Protein Design (Methods in Molecular Biology)

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Protein Design (Methods in Molecular Biology)

Manufacturer: Humana Press
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Binding: Hardcover

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ASIN: 1588295850

Book Description

Recent major advances in our understanding of modulating protein functions has led to the development of new methods and algorithms to predict and decipher how amino acid sequences shape three-dimensional structures. Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success.

The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins. Other topics of discussion include: design of structural elementary motifs, entire proteins, and interfaces of protein complexes, and of amyloidogenic polypeptides and amyloid inhibitors.
Authoritative and cutting-edge, Protein Design: Methods and Applications will be of major interest to protein scientists, biochemists, and all experimentalists selecting the strategy most adaptable for their design problem.

Advances in protein design: International workshop 1988 (GBF monographs)

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Advances in protein design: International workshop 1988 (GBF monographs)

Manufacturer: Distribution, VCH Publishers
ProductGroup: Book
Binding: Unknown Binding

Biocatalyst Design for Stability and Specificity (Acs Symposium Series)

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Biocatalyst Design for Stability and Specificity (Acs Symposium Series)

Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover

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Book Description

Highlights the diversity of approaches used in understanding the function of proteins and how this understanding is applied to improving protein design for biotechnology applications. Reports on the status of current research into the interactions underlying protein stability. Emphasizes the renaturation of functional properties from the aggregated state. Covers the relationship between protein structure and function and the design of artificial multifunctional proteins by genetic technology. Reviews recent advances in the improvement of cellulase design through recombinant technology. Examines the use of chemical modification to improve enzymes.

Biologically Active Peptides: Design, Synthesis and Utilization (Biomedical Applications of Biotechnology, Vol 1)

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Biologically Active Peptides: Design, Synthesis and Utilization (Biomedical Applications of Biotechnology, Vol 1)
David B. Weiner , and William V. Williams
Manufacturer: CRC
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Binding: Paperback

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ASIN: 0877629358

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Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.

Design, Construction and Properties of Novel Protein Molecules

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Design, Construction and Properties of Novel Protein Molecules

Manufacturer: The Royal Society
ProductGroup: Book
Binding: Hardcover

Enzyme Functionality: Design: Engineering, and Screening

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Enzyme Functionality: Design: Engineering, and Screening

Manufacturer: CRC
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ASIN: 0824747097

Book Description

Enzyme Functionality serves as a conduit for trailblazing research in enzyme engineering-relating current understanding of sequence families, the new notion of enzyme structure classes, and modern methods in protein engineering, design, and directed evolution to accelerate the development of novel enzyme functionalities. This reference gathers the diverse perspectives of nearly 80 scientists from around the globe and surveys all leading rational and random approaches to the artificial evolution of enzymes. Citing more than 1500 notable works, it outlines assays for enzyme activity, stability, and specificity and a wide variety of site-directed, redesign, and evolutionary engineering methods.

Host-Guest Molecular Interactions: From Chemistry to Biology - No. 158 (CIBA Foundation Symposia Series)

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Host-Guest Molecular Interactions: From Chemistry to Biology - No. 158 (CIBA Foundation Symposia Series)
CIBA Foundation Symposium
Manufacturer: John Wiley & Sons
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Host-Guest Molecular Interactions: From Chemistry to Biology Chairman: I.O. Sutherland 1991 Host—guest molecular interactions lead to the formation of molecular assemblies containing two or more species. It has long been recognized that such `supramolecular' association is of fundamental importance in biological processes, but it is only recently that chemists have begun to design and synthesize novel host molecules. The field is relatively new, but exciting applications are already emerging, for example in the development of molecular sensors, of new chromogenic reagents and of reagents for selective metal ion capture or for the capture of molecules such as urea. In addition, it is expected that improved understanding of the interactions in relatively simple complexes of synthetic host molecules will lead to a better understanding of the much more complex biological systems in which the host molecules are either proteins or nucleic acids. In this book the contributions from experts in the chemical and biological sciences range over intermolecular interactions in both synthetic and natural (biological) systems. Topics covered include biomimetic chemistry, the design of synthetic host molecules which mimic biological processes such as ion transport across membranes and catalysis, and the concepts of preorganization and template-directed synthesis. Molecular recognition processes involved in binding of antibiotics to peptides and to DNA and in binding of sequence-specific gene inhibitors to DNA are discussed. The potential applications of oligonucleotides with modified phosphate diester linkages as probes of DNA—protein interactions and for anti-HIV treatment are described. Interactions between proteins and other molecules and the computational modelling of interactions are considered. Related Ciba Foundation Symposia: No 119 Synthetic peptides as antigens Chairman: G.L. Ada 1986 ISBN 0 471 99838 9 No 145 Carbohydrate recognition in cellular function Chairman: E. Ruoslahti 1989 ISBN 0 471 92307 9 No 159 Catalytic antibodies Chairman: W.P. Jencks 1991 ISBN 0 471 92962 X

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A dense, but brilliant, collection of lectures

A Classic Collection

The Meaning of Relativity by Albert Einstein

Will never collect dust....

Einstein goes deeper.

The Meaning of Relativity, Fifth Edition: Including the Relativistic Theory of the Non-Symmetric Field (Princeton Science Library)
Albert Einstein
Manufacturer: Princeton University Press
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The Principle of Relativity (Dover Books on Physics)

Relativity: The Special and the General Theory (Penguin Classics)

Evolution of Physics

Relativity: The Special and the General Theory, The Masterpiece Science Edition,

Einstein's Miraculous Year: Five Papers That Changed the Face of Physics

ASIN: 0691120277

Amazon.com

In 1921, a young Albert Einstein traveled to America to give four lectures at Princeton University, paving the way for a more complete acceptance of his theory of general relativity. These lectures are published together as The Meaning of Relativity, and were revised with each new edition until Einstein's death. Despite Einstein's profession that he thought without using words, his examples and descriptions of the relativistic world he perceived are clear and easy to follow. Unfortunately for nontechnical readers, his presentation requires deep diversions into mathematics often enough to break up the flow of his narrative, and they may find this rough terrain. But for the mathematically sophisticated or the devoted scientific historian, these lectures are profoundly illuminating--Einstein's bright, quiet genius shines through in the simplicity and economy of his writing. Two appendices follow the lectures: the first covers advances and experimental verifications after 1921; the second, "Relativistic Theory of the Non-Symmetric Field," was Einstein's last scientific paper. The Meaning of Relativity documents a revolution in progress and yields to the careful student deeper truths than those found in physics textbooks. --Rob Lightner

Book Description

In 1921, five years after the appearance of his comprehensive paper on general relativity and twelve years before he left Europe permanently to join the Institute for Advanced Study, Albert Einstein visited Princeton University, where he delivered the Stafford Little Lectures for that year. These four lectures constituted an overview of his then controversial theory of relativity. Princeton University Press made the lectures available under the title The Meaning of Relativity, the first book by Einstein to be produced by an American publisher. As subsequent editions were brought out by the Press, Einstein included new material amplifying the theory. A revised version of the appendix "Relativistic Theory of the Non-Symmetric Field," added to the posthumous edition of 1956, was Einstein's last scientific paper.

Customer Reviews:

A dense, but brilliant, collection of lectures.......2007-08-30

Laymen, such as myself, are familiar with the equation e=mc2; yet how many of us non-scientists actually know what this means? Einstein explains this in a series of four lectures. While the explaination is clear, the mathematics behind it (and the implications of relativity theory) are far from easy for the layperson to understand.

The first section on space and time in pre-relativity physics provides the foundation for exactly why his theories are so revolutionary. I was able to digest this without much difficulty. The real challenges (for me at least) began with his explaination of special and general relativity - that space, time and light are dependent on each other, and in fact are (hence the name) all relative ... a real mind-bender. Sadly, I was unable to make it through the second half of the lecture on general relativity - too abstract for one who is not a scientist by training or vocation.

Nonetheless it is a worthwhile (if difficult) read. For those who are weak in mathematics (Euclidian geometry or below) much of the details will be incomprehensable; don't let this dissuade you - part of the genius of Einstein is his ability to explain what the mathematics proves. A seminal work in science, and highly recommended for those with the patience, training or deeply committed interest in the subject.

A Classic Collection.......2006-12-16

This book is an excellent collection of 'lectures' by Einstein himself and present the 'eventual' form of the Special & General Theories of Relativity (as in the 1950s). A handy accompaniment to undergraduate study in relativity, the book is a *mathematical* exposition into its broad features - and is NOT by any means a popular/lay account of what the theories mean. The title of the book may be a little dis-orienting in this regard - but the subtitle should lay to rest any doubts!

Einstein starts with pre-relativity physics formulated in the language of tensors and moves on to present the Special Theory using the same apparatus. The next two chapters delve really deep into the philosophy of the General Theory (GR) complete with equations. The Appendices are further advanced topics in GR - and may be of interest only to graduate students.

For a non-physicist like me, with a sufficent background in the requisite mathematics and some prior exposure to the topic, this book was a real treat. It is a classic well worth its place in a personal library. This book is, however, not recommended for those who are looking for something along the lines of Hawkings' A Brief History of Time.

The Meaning of Relativity by Albert Einstein.......2004-02-27

Einstein's theory seeks to unite time, space and impliedly
distance and light phenomena into a rational set of equations which are congruent to the Euclidian geometry. In essence,
the concept of time is meaningless except in relation to
light . Without light, there would be no reference point
for measuring distance in space because the whole area would
be dark and unidentifiable for scientific measurement and
comparison purposes. The use of the volumetric triple integral
seeks to make a measurement on 3-planes. i.e. x,y and z
Later in the work, Einstein explains that the laws of
configuration of rigid bodies with respect to K' do not agree
with the laws of configuration of rigid bodies that are
in accordance with Euclidean geometry. He provides an example
wherein two similar clocks rotate simultaneously on the
periphery and the center of a circle, then judged from K- the
clock on the periphery will go slower than the clock at the
center. He explains this difference as the result of the
gravitational field influence as determinants in the metric
laws of the space and time continuum. What happens when the
clocks are in a perfect vacuum? In addition, time travel is
a function of how light travels. Finite differences in the
radii of the clocks (periphery and center) imply distances with
slight changes in respect to the time light takes to travel
from one end of the radii (periphery or center) to the other.
In the Riemann Tensor, Einstein depicts an amorphous masse
dependent upon the path of displacement. The outline of the
masse approximates a square so that the area or volume is
determinate by approximation to the closest geometric form
to the amorphous masse i.e. a square

On page 92, Einstein states that the rate of a clock is slower
the greater is the masse of the ponderable matter in the
neighborhood. This comports with the theory and computation
of inertia. As the base and height increases, the inertial
computation is geometrically greater in accordance with the
formulas of inertia [ ((b x h^3)/12) ]. In the discussion of
Mach, Einstein states that the inertia of a body must increase
when ponderable masses are piled in the neighborhood. This is
proven by computing inertia utilizing more massive bases and
heights. As the base and height increases, the inertial
computation is geometrically greater thereby proving that the
inertia of a body must increase when ponderable masses are
piled up in the neighborhood.

Einstein discusses the theory of Mach in relation to inertia
and the mutual action of bodies. The actual measurement of
Mach has at least 3 different levels; namely, subsonic,
sonic and supersonic measurements

Einstein argues that the hypothesis that the universe is
infinite and Euclidean at infinity is complicated from the
relativistic point of view. The universe expands and contracts .
Accordingly, the nature tends to approximate non-Euclidean
or quasi-Euclidean objects in the evolution toward the
expansive and infinite state which Einstein postulates as
potentially Euclidean in order.

Einstein argues against an infinite space by stating:

" 1. From the standpoint of the theory of relativity , to postulate a closed universe is very much simpler than to postulate the corresponding boundary condition at infinity
of the quasi-Euclidian structure of the universe.

2. The idea that Mach expressed, that inertia depends upon the mutual action of bodies, is contained, to a first approximation,
in the equations of the theory of relativity; it follows from these equations that inertia depends, at least in part upon
mutual actions between masses.

3. An infinite universe is possible only if the mean density
of matter in the universe vanishes. Although such an assumption is logically possible, it is less probable than the assumption that there is a finite mean density of matter in the universe."

Critique:

The idea of a closed universe is simpler. It comports with experience. For instance, why does Haley's Comet return every
75 years. The idea of an infinite universe would imply the existence of a less dense outer-superstructure. As objects hurled in space, they would be drawn into the less dense regions. The idea of a bounded universe implies a boundary
to ricochet speeding objects. Otherwise, every speeding object
would continue into an infinite universe with a denseless
path of space.

To prove the third postulate, scientists must have better information on the mean density at the outer edges of the universe. Does density remain constant or does it evaporate
with greater distances toward the universe boundary regions?
If a boundary exists as postulated in the finite universe,
what is the boundary? Is the boundary a wall in space?
If so, what exists beyond the wall? At the corners of the universe, what structures exist to modulate areas of higher
density and less density or infinitestimal density?
In addition, there is a theory of an expanding universe.
How does the universe expand and what outer region accomodates
this expansion. The idea of an expanding universe admits to
an expanding boundary. Again, this poses the earlier question.
i.e. There must be free space to accomodate an expanding
universe. Is this free space dense or denseless.

This concept is similar to a computer gigobyte superstructure.
Users can define different regions on the computer disc.
These regions consist of utilized space and free space.
Conceptually, the universe may be seen in the same way.
It consists of both bounded and unbounded space.

Will never collect dust...........2002-02-03

There are numerous books on general relativity currently on the market, and these range in difficulty from those written for the beginner or the layman, those written for graduate students in physics, and research monographs covering specialized topics. It is always refreshing to go back to the originator of the subject, and take part in his special insights on the topic. Philosophers and historians of science can definitely benefit from a perusal of this book.

The author begins this book with a discussion of the origin of the concepts of space-time, the emphasis being partly philosophical and partly psychological, and the reader can see the origin of the author's operationalism in reading this introduction. He is clearly against the philosophers who attempt to remove concepts from experience and put them in his words "in the intangible heights of the a priori". The motion of rigid bodies is used to set up a discussion of Euclidean geometry and linear orthogonal transformations. The author emphasizes the role of the physicist in discerning whether a system of geometry is true or not, contrary to the pure mathematician. Examples of geometrical invariants, such as the Cartesian line element and the volume element are discussed, along with the role of vectors and tensors. Both of these are used as means by which one can give expression to the independence of Cartesian coordinates. Maxwell's equations are put in tensor notation as an example of covariance with respect to Cartesian coordinate transformations. All of this is done to motivate the theories of special and general relativity.

The theory of spectial relativity is treated in chapter 2, the author introducing his famous principle of special relativity. The author poses the problem of calculating the coordinates and time in an inertial system moving with uniform translation relative to another. He shows how this problem is solved by assuming that time and space are absolute, and if the coordinate axes of the systems are parallel to one another, the Galilean transformations result. Newton's equations of motion are covariant under these transformations, but Maxwell equations are not (but the author chooses not to show this explicitly). He then gives an in-depth discussion of how the Lorentz transformations arise as being those that guarantee the covariance of the Maxwell equations. The author also discusses the signature of the Lorentz metric and how it is related to the light cone. He ends the chapter by developing the energy tensor of the electromagnetic field and matter.

The author's rejection of inertial frames as being priveleged leads him in the beginning of the next chapter to a short philosophical critique of the principle of inertia. This leads to a discussion of the principle of equivalence and to the origin of the general theory of relativity, a theory which the author developed, amazingly, single-handedly, and which he clearly believes is very much superior to classical mechanics. The intuition to be gained by reading this chapter is invaluable for serious students of general relativity. One can see the simplicity and power of the author's arguments, relying on keen physical intuition and sound use of mathematics. In particular, the author's heuristic derivation of the gravitational field equations from Poisson's equation is briliant. In addition, he is not ashamed to interject philosophical argumentation into his writing, particularly in his discussion of Mach's principle. Such discussions are becoming more rare among physicists at the present time.

Einstein goes deeper........2001-12-28

The Meaning of Relativity is an advanced book. The title should have made it clear. Einstein delves here into what his theory
actually MEANS. That is, what must we change (if anything...) in our world conception, in the way we think, as a consequence of his immense discovery. Just think that he meddled with time, a concept static since so long that it is registered deep in our DNA: our concept of time goes back to the epoch where our main purpose was to survive the day
(sounds familiar? No, no, it was different! It was permanent. What you experience now is transient...)
So what? Read it! It is a marvellous book. Perhaps you will have to reach for other, more elementary, books, in this enterprise. All right! That almost characterizes a book worth reading. So... go on! It will repay your efforts. It IS doable. You will come out, for instance, with a precise CONSTRUCTION OF SPACE! Your brains will be enriched.You deserve that!

Book Description

Recorded history is a finely-woven magic fabric of intricate lies about events predating the sixteenth century. There is not a single piece of evidence that can be reliably and independently traced back earlier than the eleventh century. This book details events that are substantiated by hard facts and logic, and validated by new astronomical research and statistical analysis of ancient sources.

Customer Reviews:

Calculations are only as good as your numbers.......2007-08-03

Yes, we can all agree that mainstream history is nearly 100% BS due to politics, economics, ego, problems with dating techniques, and various conspiracies. Agreed. But, I've been researching the distinct possibility that human history (in terms of civilizations) are much more ancient than we've been told, so coming across this book was very interesting to me. I wondered how Fomenko could be wrong (if at all) because he is very persuasive in his presentations. Then it dawned on me. If at previous times in prehistory, due to the various catastrophies that are well documented (comets, asteroids, planetary disruptions, plasma discharge, pole reversals, etc) the Earth was in a different position in relation to the sun, different tilt on its axis, different orbit, different rotation (in terms of velocity and DIRECTION), and the continents were in different positions, then would this not cause the ancients to see the sky (constellations) differently? In other words, is Fomenko making erronious assumptions about the physics of the Earth in pre-history, which then corrupt his data with regards to dating the relevant astrology? The last event to seriously disrupt our planet occured roughly 3500 years ago, according to other good researchers, so is it possible Fomenko has been confused by this? The vastly different physics of our planet in the not so distant past may explain this confusion, which is not to say the "mainstream" version of history is correct; on the contrary. I am not an expert in these fields, but wanted to see if this idea could spark discussion.

Pants on fire?.......2007-07-19

Will people ever read before spamming? Yes, Jesuits could not rewrite world history alone, they had help. Anyway, Dr Prof Acad A.Fomenko does not point to jesuits as the driving force of world wide history manipulation in published volumes 1,2,3;, actually he barely mentions the poor devils. Check it with 'Search inside' feature, please. China is rarely mentioned either, in fact, Dr Fomenko is completely eurocentric. Right, his theory contradicts all mainstream schools of history, because in their actual state they are all built on blatantly erroneus chronology. You don't need a mysterious cabal (conspiracy) to falsify history, the falsification is its modus operandi. It is inherent to history(ians) to falsify (distort) events, as it is inherent to humans to boast as it is inherent to power (authority) to legimize itself by referrring to glorious past made to its own order. Dr Prof Fomenko and team have identified scores of instances of such manipulation in Russian, European, etc.. history, and delivered valid statistical proof thereof. His own 'reconstruction' is completely another story. Forget c14 as a valid method of dating. W.Libby has initially discovered a brilliant method of INDEPENDENT dating. Too bad, c14 method has become a joke after a forced marrige with dendrochronology with consensual chronological scale inbuilt. Radiocarbon method can't stand blind tests, but is so very productive as a rubberstamp.

Accepted History & Chronology Must Be Changed. .......2007-04-09

There is no doubt that history as most know it is a sham, & institution's version of History both University & Church is fradulent & inaccurate. Everything was established with an agenda, The real "Dark Ages" are now when we have access to incredible amounts of information past authorities & more important 'common folk' didn't have but our institutions & educators are slow to evolve because of what has ignorantly & arrogantly been taught for too long. This is on many subjects not just Chronology.

For anyone to question "Why would a Mathematician have anything credible to say of History?" The answer is from Dr. Fomenko's preface in the book: "It would be worthwhile to remind the reader that in the XVI-XVII century Chronology was considered to be a subdivision of Mathematics." These volumes could possibly be some of the most important works to date & should be read by everyone with an interest in History, especially professors & educators who have a duty to the public. I have read both books & must say that 'Chronology 1' has some very eye opening & revolutionary information. Even if these volumes are part true the implications are profound & opens the doors to further investigations & questions which must be done. I speak several different lanquages & must say the logic Dr. Fomenko uses with "inflection" of words & words being read from left to right in one region & right to left in another then written backwards, the removal of vowels & get down to basics of words, or different cities & locations having the same name etc. is correct. Vowel usage has always been optional & varied, actually complicating linquistics & study. The first thing one has to understand is that words never had a fixed spelling in history like we do now, the spelling of words was mutable & regional, as well as names & titles of people were vast, varied & changed, NOTHING WAS FIXED or understood linear. Matters of Life & Death as well as financial profiteering yesterday & today were & are made with ignorant, illogical & conspiratorial views of history & reality, it's time people get closer to the Truth & society collectively grow up.

Very Interesting.......2007-03-07

It is a good proposal and I believe it will mature into something even better in the future. I think it deserves to be read.

History as Science Fiction.......2007-01-10

Anatoly Fomenko has written a very intriguing book, full of pictures, charts, and computer 'proof' of his thesis: backwards of AD900 we don't really know what happened or when. Between AD900 and AD1600 there is more certainty, but there is still a lot of fuzzy ground, and things don't get reliable until we get past the 1600's where the printing press made it very difficult for the perpetrators of this timeline manipulation to change anything that had been committed to print. The Dark Ages did not happen. Books were burned for a reason. One organization has doubled the actual length of its existence by expanding the real chronology. Read why.

I had always wondered why Christ died about AD33 and yet men waited until the 11th century to form the Knights Templar, the Cathars, etc and go after the Holy Land by force. Why the 1000 year gap? Turns out there wasn't more than a 10-12 year gap and he proves it using astronomy. This also implies that the planet is not as old as we have been told, and current Christian and other creationist scientists are already championing that idea without being aware of Fomenko's book. The two groups, creationist scientists and the Russian mathematical analysts corroborate each other. Fascinating.

Of course, all this flies in the face of what we have been told traditionally is the 'proper' chronology of western civilization, and most readers will experience 'cognitive dissonance' in reading this book. It means that our history going backwards from AD1600 becomes progressively more incorrect and unreliable until it cannot be trusted at all... in the space of 700-800 years.

Naturally, the curious, open-minded reader will want to know WHO did this, WHY, and did any of the events we think of as really ancient ever happen?
Dr. Fomenko is a respected scientist/mathematician at Moscow State University who has already answered these questions to the satisfaction of his initially skeptical colleagues. Most of them are now believers, a few still refuse to believe (the usual diehards), and of course the western press has ignored Fomenko's work -- for obvious reasons when you read the book. The ones who perpetrated this chronology ruse have a lot to answer for. They are still with us. That's why this book is a well-kept secret.

I gave the book a 4-star rating because I was unable to check out some of his claims; those I checked were as he said. But if even 1/3 of his claims are true, this punches a big hole in what we think is our history, the meaning of western civilization, our educational process (for repeating the ruse as gospel), and the trustworthiness of the organization that perpetrated this ruse, well-intentioned or not.

This book relates to current research into a Young Earth paradigm, to John Keel's discoveries about our planet, and Fr Malachi Martin's insights (in his now out-of-print books). We are indeed sheep who are manipulated and kept ignorant -- for a reason. While knowing what these men have to say may be the "booby prize" (as in: 'what can you do with this knowledge?'), it will provide interesting reading. Didn't someone say: "...and the Truth will set you free."?? For you to judge if this book contains the truth.

Italian Tales: An Anthology of Contemporary Italian Fiction (Italian Literature and Thought)

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Italian Tales: An Anthology of Contemporary Italian Fiction (Italian Literature and Thought)

Manufacturer: Yale University Press
ProductGroup: Book
Binding: Paperback

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Anthologies | Short Stories | Literature & Fiction | Subjects | Books

General | Short Stories | Literature & Fiction | Subjects | Books
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ASIN: 030012371X

Book Description

This anthology serves as a literary map to guide readers through the varied geography of contemporary Italian fiction. Massimo Riva has gathered English-language translations of short stories and excerpts from novels that were originally published in Italian between 1975 and 2001. As an expression of a communal contemporary condition, these narratives suggest a new sensibility and a new way of seeing, exploring, and inhabiting the world, in writing.
Riva provides a comprehensive introduction to Italian literary trends of the past twenty years. Each selection is preceded by a short introduction and biography of the writer. For English-language readers who are familiar with the work of Italo Calvino and Umberto Eco, this collection presents an opportunity to acquaint themselves with the work of other important contemporary Italian writers of fiction.

Italian Tales: An Anthology of Contemporary Italian Fiction

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Italian Tales: An Anthology of Contemporary Italian Fiction
Massimo Riva
Manufacturer: Yale University Press
ProductGroup: Book
Binding: Paperback
ASIN: B000OS6X7M

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