DNA Replication and Human Disease (Cold Spring Harbor Monograph) (Cold Spring Harbor Monograph)

Book Description

In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest. This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment.

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Dna Replication
Arthur Kornberg
Manufacturer: University Science Books
ProductGroup: Book
Binding: Paperback

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ASIN: 1891389440

Assembly and Action of a Primosome in DNA Replication in E. Coli

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Assembly and Action of a Primosome in DNA Replication in E. Coli
George C. Allen
Manufacturer: George C. Allen
ProductGroup: Book
Binding: Hardcover
ASIN: B000Q7G0D8

Chromatin Dynamics in Cellular Function (Results and Problems in Cell Differentiation)

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Chromatin Dynamics in Cellular Function (Results and Problems in Cell Differentiation)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 3540336850

Book Description

This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. Topics covered include the structure and function of protein modules within chromatin-remodeling proteins, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair, and current models of nucleosome-remodeling mechanisms.

Chromosome Damage and Repair (Nato a S I Series Series a, Life Sciences)

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Chromosome Damage and Repair (Nato a S I Series Series a, Life Sciences)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Cold Spring Harbor Symposia on Quantitative Biology: DNA : Replication and Recombination/Vol 43

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Cold Spring Harbor Symposia on Quantitative Biology: DNA : Replication and Recombination/Vol 43

Manufacturer: Cold Spring Harbor Laboratory Pr
ProductGroup: Book
Binding: Hardcover

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ASIN: 0879690429

Comprehensive Virology:Reproduction of Bacterial DNA Viruses (Comprehensive Virology)

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Comprehensive Virology:Reproduction of Bacterial DNA Viruses (Comprehensive Virology)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Concepts in Eukaryotic DNA Replication

Manufacturer: Cold Spring Harbor Laboratory Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0879695579

DNA Repair and Replication, Volume 69 (Advances in Protein Chemistry)

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DNA Repair and Replication, Volume 69 (Advances in Protein Chemistry)

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0120342693

Book Description

DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters.

Selected Contents:
-Base Excision Repair
-Eukaryotic DNA Mismatch Repair
-Double Strand Break Repair
-Functions of DNA Polymerases
-Somatic Hypermutation: A Mutational Panacea

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A Solid Overview.......2005-07-05

The Feynman Lectures on Statistical Mechanics contain a great deal of very useful information, and each page is full of solid work without bothering too much with unnecessary details. The book also covers all the bases very well, hitting plenty of good examples, such as spin waves, and the obligatory superconductivity chapter is a solid introduction.

My only complaint is that the ordering of the book is a little haphazard. I understand that it is difficult to include quantum and classical statistical mechanics in one continuous run, but the book seems to jump around a bit.

All this considered, the book is probably a must-buy for people interested in statistical physics, as it is one of the better general overview books available (I despise the Reif; it needs to be updated and completely rearranged), and, as an added bonus, you get to see the Onsager solution to the 2-D Ising model. Cheers!

a tremendous book.......2005-02-02

when i was undergrad, i read Prof. Kerson Huang's stat mech. i think that book is good. everything is covered systematically, but everything is explained 'evenly'. if u r a careful reader, u still get the ideas of the essence, like partition function plays the central role of stat mech, etc.

now, i am reading feynman's book. it's totally diff from huang's. it's full of excitement. he put the principle of stat mech which is the relation b/w partition function and probability at the very beginning. all the other aspects in stat mech follow so straight forword and there are endless novel derivations in this book. i feel many of my previous understandings are interconnected by reading this book.

it's simply great, just like the other books written by feynman.

Style over substance........2003-12-30

Feynman was one of the most accomplished physicists in the 2nd half of the 20th century. His publications speak for themselves. However, as represented in this set of lecture notes, I do not find him as a pedagogue more enlightening than others. I bought and read this book in grad school, and found it to be a nice quick intro to several topics (spin waves and such). I did not, and still don't find the exposition physically exceptionally profound. One difference though, is the fact that Feynman, with his fame, could afford to be rather informal in his presentation. Any unsatisfactory aspects would be accepted as the mysterious ways of a 'genius'. If you are a student and would like to learn to solve problems on your own, forget this one. What this book gives you is a little 'attitude', aside from a quick intro, which most of us haven't earned the right to put on, of doing physics. Try it. Try to be as unorthodox and informal as he was, and you will mostly end up with nonsense.

extraordinary Masterpiece!.......2003-01-24

Richard Feynman said:"What I cannot create, I do not understand!". I am really amazed by his unique style of doing physics: he always create anything from scratch, always has his unique point of view, even on an old problem. All I can say about Feynman is Genius!!!
This book is about Feynman's extraordinary viewpoint on statistical mechanics. I can bet that this is an unique S.M book.
but i don't think it's for beginner, I suggest you should finish a standard statistical mechanics course before you read this one.
I can not find suitable words to admire this great book, so I quit here, but in the end, I strongly recommend this book to all physicists, physics-major students!

Statistics that "moos you along".......2002-01-14

A classic by one of the best. I wish I could say I understand
it all, but it rings true in many ways. His famous quote
"I can definitely say that Nobody understands Quantum Mechanics"
is perhaps this biggest "Moo Clue".

Statistical Mechanics: A Set of Lectures.

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Statistical Mechanics: A Set of Lectures.
Richard P. Feynman
Manufacturer: Publisher Unknown
ProductGroup: Book
Binding: Paperback
ASIN: B000UYCF0Y

Statistical Mechanics: A Set of Lectures (Advanced Book Classics)

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Statistical Mechanics: A Set of Lectures (Advanced Book Classics)
Richard Phillips Feynman
Manufacturer: Perseus Books Group
ProductGroup: Book
Binding: Paperback
ASIN: B000OLMBW0

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Statistical Mechanics: A Set of Lectures.
Richard P. Feynman
Manufacturer: Publisher Unknown
ProductGroup: Book
Binding: Paperback
ASIN: B000UG3IKI

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Much great prose

Diamonds mixed with mud dumped in Iceland

Selected Prose 1909-1965 (New Directions Paperbook)
Ezra Pound
Manufacturer: New Directions Publishing Corporation
ProductGroup: Book
Binding: Paperback

General | Essays | Literature & Fiction | Subjects | Books
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Early Writings

Ezra and Dorothy Pound: Letters in Captivity, 1945-1946

Robert Frost: Collected Poems, Prose, and Plays (Library of America)

The Cambridge Companion to Ezra Pound (Cambridge Companions to Literature)

ASIN: 0811205746

Customer Reviews:

Much great prose.......2005-10-11

I love a lot of the writing in this book: Pound's obit for Eliot, the opening note, the essays on Confucius and Mencius, the essay on Adams and Jefferson, etc. Robert Anton Wilson also highly recommends this book.

Diamonds mixed with mud dumped in Iceland.......2003-08-07

..The book does contain vaulable insights, and information, but mostly in reference to other books and or people. The section devoted to Confucius could be summed up as saying "Ezra Pound really liked Confucius for reasons he never seemed to get around to mentioning." Because of this book I am even more curious about the economics of Silvio Gesell and I plan to read the Adams-Jefferson letters. I also want to find out more about the economic history of the United States. But this book has only pointed me in these directions, but it provides frusteratingly little information on these subjects. In the early part of the book Pound uses the metaphor "diamonds mixed with mud and then dumped in Iceland" to describe, well I completely forget, but it's an apt metaphor for this book. There are gems there but you have to dig and dig and dig.
So it gets one star. So what is five stars? Those are books that in the humble opinion of the reviewer should be read by every man, woman, child, Irishperson, and dog on the planet. For example S.I. Hiyakawa's Language in Thought and Action or Robert Anton Wilson's Quantum Psychology... Thanks for your attention.

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Uncovering or rediscovering the unsainted.

Ezra Pound Selected Prose 1909 - 1965

Manufacturer: A New Directions Book
ProductGroup: Book
Binding: Hardcover
ASIN: B000GVK7F6

Customer Reviews:

Uncovering or rediscovering the unsainted........2007-07-16

Inarguably America's most prolific poet and essayist, Pound is probably the most influential of all American poets and possibly the best. This collection of essays gives a more representative view of the complete thinker in all fields of knowledge than does the collection assembled by T. S. Eliot. Pound comes out of the line of Donne and Browning--more musician than painter, more an inhabitant of time than of space, an awesome organic discourse machine (before word-processing, even!), whose syntactical energies, whether in verse or prose, are always fascinating if not compelling (the "content" is another matter).

Having survived Browning's Sordello (which I'm unconvinced Pound did, or he wouldn't be making ridiculous statements about moving on to a more "modern" form of poetic discourse), I thought I'd give its offspring some of my time. Too many discussions of Pound simply apologize quickly and awkwardly for his anti-semiticism, and move on. Given all the "suspected" and covert anti-Semites in the arts, give Pound credit, at least, for the courage of his convictions (like a suicide bomber), regardless of how wrong-headed they were. Also, it may be necessary to give more attention to his writings in this area (admittedly often ramblings) to come to a better understanding of the most notoriously difficult poem by an American poet, "The Cantos." Pound obsesses on the subject of "usury" for a hundred or more pages in this prose collection, enough to allow the reader to see in greater clarity the connection between the American and Italian authors of literature's two most famous "Cantos," since Dante provides a place for usurers in the eighth, penultimate circle of The Infernal.

Pound's view of modern economics, of course, is wildly reactionary and hopelessly fantastical in addition to the unfortunate (especially for him) scapegoating and personified demons that it gave rise to--whether metaphorical, literal, or a mixture of both often hard to say, though the effect remains the same: Pound's ranting against usury and its practitioners led to his being viewed not merely as anti-semitic, anti-free enterprise, unpatriotic, but criminally insane; similarly, D. H. Lawrence's incessant (and insistent) preaching about the glories of sex and his denunciation of all things WASPish led to his being branded little more than a pervert if not a dirty old man.

In both cases, it's not sufficient to ignore or "excuse" the distasteful parts. Without such dispositions, excesses, obsessions, etc., neither writer would have been the artist he was. In fact, perhaps with the exception of the few inferior creators who pass Tolstoy's morality test, bid the artist and his art goodbye. Commerce will always manage to fill the void.

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Selected Prose 1909-1965
Ezra Pound
Manufacturer: Faber & Faber, London
ProductGroup: Book
Binding: Paperback
ASIN: B000TJVDS0

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Selected Prose 1909-1965

Manufacturer: Faber & Faber, London
ProductGroup: Book
Binding: Paperback
ASIN: B000I9DSWU

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