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Chemokines and Viral Infection (Current Topics in Microbiology and Immunology)
Manufacturer: Springer ProductGroup: Book Binding: Hardcover ASIN: 3540292071 |
Book Description
Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. Within a relatively short period of time, early participants within the field determined that these proteins displayed distinct and conserved structural features and exerted potent chemotactic effects on defined lymphocyte subsets. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. The host response to viral infection represents a well-orchestrated ballet consisting of numerous participants with diverse roles in defense but with the ultimate goal of generating virus-specific lymphocytes whose job is to control and eliminate the invading viral pathogen from infected tissues. Over the years, an emerging picture has developed that indicates that chemokines and their receptors are intimately involved in development of effective host responses to viral pathogens. Chemokine expression is now associated with all facets of defense against viral infection including linking innate and adaptive immune responses.
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Cytokines in Severe Sepsis & Septic Shock (Progress in Inflammation Research)
Manufacturer: Birkhäuser Basel ProductGroup: Book Binding: Hardcover ASIN: 3764358777 |
Book Description
This book deals with the central role of cytokines in the generalized inflammatory response of the host as the consequence of severe infection/endotoxin action. International specialists cover several aspects in 20 chapters starting with the agents responsible (endotoxin, superantigens) and recognition during cytokine induction. Further chapters deal with the signal transduction cascade, its modulation due to sex or genetic polymorphism, and the possibilities and problems in detection (including surrogate markers). Major targets of actions are covered in the chapters on coagulation/fibrinolysis, adherence molecules, vasoactive factors, apoptosis and metabolism. As not all actions of cytokines are beneficial, several chapters deal with the prevention of induction, modulation of the cytokine generation or scavenging cytokines including gene therapy approaches. Models are necessary for obtaining pathophysiological information and for testing therapeutic approaches, and thus all chapters deal with exper imental mo dels as well as clinical trials. The reasons why these have failed so far are the subject of the final chapter.Researchers and students of Critical Care Medicine and Biomedicine will find up-to-date reviews and data in this book.
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Cell-Cell Interactions in the Release of Inflammatory Mediators: Eicosanoids, Cytokines and Adhesions (Advances in Experimental Medicine and Biology)
Manufacturer: Springer ProductGroup: Book Binding: Hardcover ASIN: 030644108X |
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Immunophysiology: The Role of Cells and Cytokines in Immunity and Inflammation
Joost J. Oppenheim , and Ethan M. Shevach Manufacturer: Oxford University Press, USA ProductGroup: Book Binding: Paperback ASIN: 019507064X |
Book Description
This exciting new text describes how cells normally regulate immunological and inflammatory reactions, and how the immune system is intimately related to other bodily functions. The authors consider the effects of lymphokines on non-inflammatory cells and tissues, including connective tissue and the neuroendocrine system, and describe the effects of neuroendocrine and peptide growth factors produced by non-inflammatory cells and tissues on the functions of immune cells. To highlight the factors regulating immunophysiological functions, they discuss the inflammatory consequences of endotoxin, immune complexes, and complement; the interactions of immunomodulating epidermal factors and immune tissue; the modulation interactions of immunomodulating epidermal factors and immune tissue; and the modulation of immunity by cytokines. The mechanisms by which the immune system normally contends with bacterial, viral or tumor challenges are examined, with an emphasis on basic concepts and key experimental results; and the cells directly involved in host-defense processes are discussed. Wherever possible, information about in vivo and in vitro human immune responses is presented.
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Cancer and Inflammation (Progress in Inflammation Research)
Manufacturer: Birkhäuser Basel ProductGroup: Book Binding: Hardcover ASIN: 3764365927 |
Book Description
How are cancer and inflammation interrelated mechanistically and clinically? Though extensive literature exists on the topic "Cancer and Inflammation", there are relatively few texts that have truly integrated the two in spite of the many common mechanisms shared by their processes. Certainly, areas such as cytokines, growth factors, proliferation, signal transduction and angiogenesis, for example, are found in both. Yet, the dynamics of how these common mechanisms are maybe interrelated in the pathologies of the two is not widely covered. Such coverage, as presented in this volume, may help further understanding and bring new approaches to therapeutics.
The first section of the book discusses inflammatory mechanisms, studied in cellular and animal studies. The second part concentrates on clinical studies with antiinflammatory drugs in cancer treatment. The volume is written for biomedical researchers in the health care industry and in academia who are working in these areas.
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Cells and Cytokines in Lung Inflammation (Annals of the New York Academy of Sciences)
Marina Pretolani Manufacturer: New York Academy of Sciences ProductGroup: Book Binding: Hardcover ASIN: 0897668553 |
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Current Concepts in Autoimmunity and Chronic Inflammation (Current Topics in Microbiology and Immunology)
Manufacturer: Springer ProductGroup: Book Binding: Hardcover ASIN: 3540297138 |
Book Description
The ethiopathologies of autoimmune diseases are complex. A broad variety of cell types and gene products are involved. However, clinical and experimental evidence suggests that the importance of an individual factor changes during the course of the disease. Factors and cell types that induce acute autoreactivity and initiate an autoimmune disease could be distinct from those that drive a chronic course of that disease
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Cytokines and Adhesion Molecules in Lung Inflammation (Annals of the New York Academy of Sciences)
France) Conference on Cytokines and Adhesion Molecules in Lung Inflammation (1995 : Paris Manufacturer: New York Academy of Sciences ProductGroup: Book Binding: Hardcover ASIN: 0897669797 |
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Cytokines and Inflammation (Telford Press)
Edward S. Kimball Manufacturer: CRC ProductGroup: Book Binding: Hardcover ASIN: 0849388066 |
Book Description
This important new book focuses on the involvement of cytokines in specific areas of inflammatory diseases, such as granulomatous responses, lung disease, hepatic dysfunction and the acute phase, arthritis and accompanying bone remodeling, neurogenic inflammation, and shock. The roles of GM-CSF, IL-6, IL-2, TGFb EGF, and LIF are discussed, as well as the medical treatments that affect cytokine activity. The results of approaches important to the biotechnology and pharmaceutical industries, such as the search for endogenous biological response modifiers that control cytokine function or production, attempts to synthesize heterocyclic compounds in the organic chemistry lab, and research regarding second messenger pathways involved in IL-1 and TNF production are examined. This book will provide anyone in cytokine research, especially clinical investigators, pharmaceutical industry researchers, and academic research scientists, with important information on how cytokine research might be used.
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Cytokines and Joint Injury (Progress in Inflammation Research)
Manufacturer: Birkhäuser Basel ProductGroup: Book Binding: Hardcover ASIN: 3764370017 |
Book Description
This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of well-known and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. New information on the novel cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay is provided, in addition to an outline of the role of established cytokines, such as TNF, IL-1 and IL-6. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher.
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Rheology and Processing of Liquid Crystal Polymers
Manufacturer: Springer ProductGroup: Book Binding: Hardcover ASIN: 0412596407 |
Book Description
This book explains the principles underlying the flow of liquid crystal polymers and of blends involving these materials, and how the rheological properties influence processing behaviour. It is assumed that the reader is familiar with rheology, but not with liquid crystalline polymers. It is written by an international group of authors.
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Thomson Advantage Books: Inquiry Into Physics (with InfoTrac ) (Thompson Advantage)
Vern J. Ostdiek , and Donald J. Bord Manufacturer: Brooks Cole ProductGroup: Book Binding: Ring-bound Similar Items:
ASIN: 0534424694 |
Book Description
Save money with THOMSON ADVANTAGE BOOKS: INQUIRY INTO PHYSICS with InfoTrac®! With the integration of simple mathematics, this physics text is designed to help you See the practicality of physics in your daily life. Tools found throughout the text such as concept maps, Mapping It Out Exercises, Physics Family Album, Learning Checks, and photographs and illustrations help you visualize and understand abstract concepts. Preparing for exams is easy with the book-specific website that contains study aids such as chapter outlines, tutorial quizzes, flashcards, and more.Customer Reviews:
Jappleby.......2007-07-15
Excellent Physics 101 book.......2007-01-05
Book.......2006-11-15
THIS is a book?!.......2006-10-29
Physics.......2006-02-01
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Inquiry into Physics (with InfoTrac )
Vern J. Ostdiek , and Donald J. Bord Manufacturer: Brooks Cole ProductGroup: Book Binding: Paperback Similar Items:
Accessories:
ASIN: 0534491685 |
Book Description
See the practicality of physics in your daily life with INQUIRY INTO PHYSICS with InfoTrac®! With the integration of simple mathematics, this physics text is designed to help you succeed. Tools found throughout the text such as concept maps, Mapping It Out Exercises, Physics Family Album, Learning Checks, and photographs and illustrations help you visualize and understand abstract concepts. Preparing for exams is easy with the book-specific website that contains study aids such as chapter outlines, tutorial quizzes, flashcards, and more.Customer Reviews:
Great as far as text books go..........2003-09-10
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Inquiry into Physics
Vern J. Ostdiek , and Donald J. Bord Manufacturer: West Publishing Company ProductGroup: Book Binding: Paperback ASIN: 0314043543 |
Book Description
A good balance of quantitative and conceptual material integrating simple math into the conceptual physics framework so students see the practicality of physics and have a means of testing its validity.
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Contributions to solar physics: I. A popular account of inquiries into the physical constitution of the sun, with special reference to recent spectroscopic ... the French Academy of sciences, with notes
Norman Lockyer Manufacturer: Macmillan and Co ProductGroup: Book Binding: Unknown Binding ASIN: B0006ADZBA |
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Inquiry into Physics (with InfoTrac 1-Semester Printed Access Card)
Vern J. Ostdiek , and Donald J. Bord Manufacturer: Brooks Cole ProductGroup: Book Binding: Paperback Similar Items:
ASIN: 0495119431 |
Book Description
This text emphasizes conceptual understanding within a problem-solving framework, using modern applications such as iPods, metal detectors, sundogs, kaleidoscopes, and smoke detectors to demonstrate the relevance of physics in our daily lives.
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Inquiry into Physics Second Edition
Vern J.; Bord, Donald J. Ostdiek Manufacturer: West Publishing Company ProductGroup: Book Binding: Paperback ASIN: B000OUBIGG |
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The peep-hole of the present,: An inquiry into the substance of appearance. Preface by Sir Arthur Eddington
Samuel Roth Manufacturer: Philosophical Book-club ProductGroup: Book Binding: Unknown Binding ASIN: B0007E9VF4 |
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The peep-hole of the present: An inquiry into the substance of appearance
Samuel Roth Manufacturer: Boar's Head Books ProductGroup: Book Binding: Unknown Binding ASIN: B0006PHRDW |
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Contribution to solar physics: I.A popular account of inquiries into the physical constitution of the sun, with special reference to recent spectroscopic ... the French Academy of sciences, with notes
Joseph Norman Lockyer Manufacturer: Macmillan and Co ProductGroup: Book Binding: Unknown Binding ASIN: B00085PN5Y |
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Franklin and Newton;: An inquiry into speculative Newtonian experimental science and Franklin's work in electricity as an example thereof (Memoirs of the American Philosophical Society)
I. Bernard Cohen ProductGroup: Book Binding: Unknown Binding ASIN: B0007ESSLC |
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Beth Henley, Vol. 2: Collected Plays, 1990-1999 (Contemporary Playwrights)
Beth Henley Manufacturer: Smith & Kraus ProductGroup: Book Binding: Hardcover Similar Items:
ASIN: 1575252007 |
Book Description
Control FreaksSignature
The Revelers
L. Play
Abundance
Impossible Marriage
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