Heterotrimeric G-Protein Effectors, Volume 238 (Methods in Enzymology)

Book Description

This volume of Methods in Enzymology and its companion Volume 237 include molecular, biological, and biochemical methods for the study of cell surface heterotrimeric G proteins and their effectors. Methods unique to signal transducing G proteins and general techniques that have been applied to the study of G protein systems are covered.

Book Description

Quality measurement, control, and improvement in combinatorial chemistry
Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable."
To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering:
* Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis
* High-throughput analytical methods used to analyze the quality of libraries
* High-throughput purification techniques
* Analytical methods applied in post-synthesis and post-purification stages
Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques.
This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.

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Chemical Applications of Graph Theory
Alexandru T. Balaban
Manufacturer: Academic Press Inc.,U.S.
ProductGroup: Book
Binding: Hardcover

General & Reference | Chemistry | Science | Subjects | Books

Chemical Applications of Topology and Graph Theory (Studies in Physical & Theoretical Chemistry)

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Chemical Applications of Topology and Graph Theory (Studies in Physical & Theoretical Chemistry)

Manufacturer: Elsevier
ProductGroup: Book
Binding: Hardcover

General & Reference | Chemistry | Science | Subjects | Books

Geometry of Chemical Graphs: Polycycles and Two-faced Maps (Encyclopedia of Mathematics and its Applications)

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Geometry of Chemical Graphs: Polycycles and Two-faced Maps (Encyclopedia of Mathematics and its Applications)
Michel Deza , and Mathieu Dutour Sikiric
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Hardcover

Book Description

Polycycles and symmetric polyhedra appear as generalisations of graphs in the modelling of molecular structures, such as the Nobel prize winning fullerenes, occurring in chemistry and crystallography. The chemistry has inspired and informed many interesting questions in mathematics and computer science, which in turn have suggested directions for synthesis of molecules. Here the authors give access to new results in the theory of polycycles and two-faced maps together with the relevant background material and mathematical tools for their study. Organised so that, after reading the introductory chapter, each chapter can be read independently from the others, the book should be accessible to researchers and students in graph theory, discrete geometry, and combinatorics, as well as to those in more applied areas such as mathematical chemistry and crystallography. Many of the results in the subject require the use of computer enumeration; the corresponding programs are available from the author’s website.

Computational Chemical Graph Theory: Characterization, Enumeration, and Generation of Chemical Structures by Computer Methods (Ellis Horwood Series)

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Computational Chemical Graph Theory: Characterization, Enumeration, and Generation of Chemical Structures by Computer Methods (Ellis Horwood Series)
N. Trinajstic , S. Nikolic , J. V. Knop , W. R. Muller , and K. Szymanski
Manufacturer: Ellis Horwood Ltd
ProductGroup: Book
Binding: Hardcover

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Molecular Chemistry | Chemistry | Science | Subjects | Books

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Graph Theory and Its Application to Chemistry: Kinetics and Reaction Mechanisms

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Graph Theory and Its Application to Chemistry: Kinetics and Reaction Mechanisms
A.L. Goodson , L.A. Petrov , O.N. Temkin , D. Bonchev , P. Plath , and E. Hass
Manufacturer: Abacus Pr
ProductGroup: Book
Binding: Textbook Binding
ASIN: 0856264555

Book Description

Modeling hydrologic changes and predicting their impact on watersheds is a dominant concern for hydrologists and other water resource professionals, civil and environmental engineers, and urban and regional planners. As such changes continue, it becomes more essential to have the most up-to-date tools with which to perform the proper analyses and modeling of the complex ecology, morphology, and physical processes that occur within watersheds. An application-oriented text, Modeling Hydrologic Change: Statistical Methods provides a step-by-step presentation of modeling procedures to help you properly analyze and model real-world data. The text addresses modeling systems where change has affected data that will be used to calibrate and test models of the system. The use of actual hydrologic data will help you learn how to handle the vagaries of real-world hydrologic-change data. All four elements of the modeling process are discussed: conceptualization, formulation, calibration, and verification. Although the book is oriented towards the statistical aspects of modeling, a strong background in statistics is not required. The statistical and modeling methods discussed here will be of value to all disciplines involved in modeling change. With approximately 100 illustrations, Modeling Hydrologic Change will equip you with an understanding with which to perform the proper analyses and modeling of the complex processes that occur across various disciplines.

Statistical Analysis of Extreme Values: From Insurance, Finance, Hydrology and Other Fields

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Lack of practical insight
Brilliant book!

Statistical Analysis of Extreme Values: From Insurance, Finance, Hydrology and Other Fields
R.D. Reiss , M. Thomas , and R.-D Reiss
Manufacturer: Birkhauser Boston
ProductGroup: Book
Binding: Paperback

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ASIN: 3764357681

Book Description

57681

"The book is well written. It assumes a knowledge of statistics, but many of the ideas and techniques can be used by a nonstatistician. As a handbook for XTREMES, it is excellent , and I recommend it highly." --Computing Reviews

"The present book is a valuable contribution to the various theoretical and applied problems in the area of extreme value theory...a pleasure to read." --Statistics & Decisions

"This book is complemented by an excellent statistical package on CD ROM... The book is however much more than a manual for the program and it would provide an excellent introduction to the subject for any statistician looking for a practical introduction to the subject of extreme values." -- J. Time Series Analysis

"With general statistics software, appropriate tools for the analysis of real extreme value problems are rarely provided. XTREMES excellently fills this gap in the statistics software market." --Computational Statistics

"For a practitioner from industry, insurance, or finance who is less concerned with understanding the underlying probability and more interested in applications, this new book will be a good buy." --JASA The statistical analysis of extreme data is important for various disciplines, including insurance, finance, hydrology, engineering and environmental sciences. This book provides a self-contained introduction to the parametric modeling, exploratory analysis and statistical inference for extreme events. Besides numerous data-based examples, the book contains special chapters about insurance (coauthored by M. Radtke), returns in asset prices (coauthored by C.G. de Vries), and flood frequency analysis. In addition, five longer case studies are included.The applicability of the system is enhanced by the Pascal-like integrated programming language XPL.

Contents:

Preface XTREMES: An Overview and the Hierarchy List of Special Symbols I. Modeling and Data Analysis

1. Parametric Modeling 1.1 Applications of Extreme Value Analysis 1.2 Observing Exceedances and Maxima 1.3 Modeling by Extreme Value Distributions 1.4 Modeling by Generalized Pareto Distributions 1.5 Quantiles, Transformations and Simulations 1.6 Robust Statistics: A Converse View 1.7 Implementation in XTREMES

2. Diagnostic Tools 2.1 Visualization of Data 2.2 Excess and Hazard Functions 2.3 Fitting Parametric Distributions 2.4 Q-Q and P-P Plots 2.5 Trends, Seasonality and Autocorrelation 2.6 Clustering of Exceedances 2.7 Implementation in XTREMES

II. Statistical Inference in Parametric Models

3. An Introduction to Parametric Inference 3.1 Estimation 3.2 Confidence Intervals 3.3 Test Procedures and p- Values 3.4 Inference in Poisson and Mixed Poisson Models 3.5 Implementation in XTREMES

4. Extreme Value Models 4.1 Estimation in Extremes Value Model 4.2 Testing Extreme Value Models 4.3 Extended Extreme Value Models and Related Models 4.4 Implementation in XTREMES

5. Generalized Pareto Models 5.1 Estimation in Generalized Pareto Models 5.2 Testing Generalized Pareto Models 5.3 Statistics in Poisson-GP Models 5.4 Extending Generalized Pareto Models 5.5 Implementation in XTREMES

6. Advanced Statistical Analysis 6.1 Non-Random and Random Censoring 6.2 Modeling Exceedances by Poisson and Mixed Poisson Processes 6.3 Mean and Median T- Year Thresholds 6.4 Models of Time Series, the Extremal Index 6.5 Rates of Convergence and Penultimate Distributions 6.6 Implementation in XTREMES

III. Elements of Multivariate Statistical Analysis

7. Basic Multivariate Concepts and Visualization 7.1 An Introduction to Basic Multivariate Concepts 7.2 Visualizing Multivariate Data 7.3 Multivariate Parametric Models 7.4 Implementation in XTREMES

8. Multivariate Maxima 8.1 Nonparametric and Parametric Extreme Value Models 8.2 Estimation in Extreme Value Models 8.3 Implemetation in XTREMES

IV. Topics in Insurance, Finance and Hydrology

9. The Impact of Large Claims on Acturial Decisions /co-authored by M. Radtke 9.1 Numbers of Claims and the Total Claim Amount 9.2 Estimation of the Net Premium 9.3 Segmentation According to the Probable Maximum Loss 9.4 The Reserve Process and the T- Year Initial Review 9.5 Elements of Ruin Theory 9.6 Implemenatation

10. Extreme Returns in Asset Prices /co-authored by C.G. de Vries 10.1 Empirical Evidence in Returns Series and Exploratory Analysis 10.2 ARCH and Stochastic Volatility Structures 10.3 Implementation in XTREMES

11. Site - Specific Flood Frequency Analysis 11.1 Analyzing Annual Flood Series 11.2 Analyzing Partial Duration Series 11.3 Implementation in XTREMES

V. Case Studies in Extreme Value Analysis

Study 1 Extreme Sea Levels in Venice/ A.M. Ferreira

Study 2 Extreme Life Spans/ R.-D. Reiss

Study 3 Extrapolating Life Tables to Extreme Life Spans: A Regression Approach Using XPL/ E. Kaufmann & C. Hillgärtner

Study 4 A Case Study of Ozone Pollution with XTREMES/ T. Hsing

Study 5 Global Warming in Relation with the Clustering of Extremes/ J. Hüsler

Appendix: An Introduction to XTREMES

A. The Menu System A.1 Installation A.2 Becoming Acquainted with the Menu System A.3 Technical Aspects of XTREMES A.4 List of Windows and XTREMES Commands

B. UserFormula Facilities

C. The XPL Programming Language C.1 Programming with XPL: First Steps C.2 Generating and Accessing Data C.3 Plotting Curves C.4 Implementing Estimators C.5 Advanced XPL Techniques

Author Index Subject Index Bibliography

Customer Reviews:

Lack of practical insight.......2001-09-20

Although the treatment of many extreme values distributions is rather complete at a theoretical point of view, very few practical considerations with respect to the actual way one should use these various EV models is provided. Unless you already know which class of EV distribution to use in your case, this book will not serve much. An overly important aspect of fitting distributions concerns the family of distribution to use for fitting a particular data, and here i haven't found much insight about practical considerations in this book. This is an important gap in this book because it is due to be practical.

On the other hand, the estimation of particular EV distributions is thoroughly covered, with theoretical (many references) and practical issues (for the estimation only) well described in every section.

Another negative point concerns the distribution of XTREMES provided with the book which is far from complete, and with bugs (changing on-line the values of the parameters of some distributions makes it crash...). I consider this book as a theoretically extended version of the manual of XTREMES, but not a self-sontained statistical book.

In summary, if you are interested in a very specific EV family, then this book can be useful, but not as a textbook. Rather go to Castillo (EV in engineering) for a good textbook on EV distributions.

Brilliant book!.......2000-08-07

Especially it is very interesting and advantageous in parts of EVT applicacation in Insurance and Finance!

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Statistical Modelling in Hydrology
Robin T. Clarke
Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Paperback

General | Science | Subjects | Books

Statistical Analysis of Extreme Values: with Applications to Insurance, Finance, Hydrology and Other Fields

Average customer rating:

looks the same as first edition but is expanded
emphasizes applications using XTREMES software

Statistical Analysis of Extreme Values: with Applications to Insurance, Finance, Hydrology and Other Fields
Rolf-Dieter Reiss , and Michael Thomas
Manufacturer: Birkhauser
ProductGroup: Book
Binding: Paperback

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ASIN: 3764364874

Customer Reviews:

looks the same as first edition but is expanded.......2002-04-24

The second edition came out in 2001 and although my previous review is listed here it refers to the first edition. Professor Reiss sent me a copy of the second edition and I browsed through it to see what has changed. Except for the words "Second Edition" in the upper left corner of the cover page the cover is the same as the original. A closer look through the text shows that there are substantial changes. The original text was 316 pages long with 35 references and a CD Rom on the back page. The new edition is 443 pages with 51 references and a CD Rom on the back page (this is version 3.0 of Xtremes).

The preface to the second edition tells you precisely what is added. There are 8 new contributing authors who are Stuart Coles , Jurg Husler, Daniel Dietrich, Dietnar Pfeifer, Humberto Vaquera, Jose Villasenor, Pieter van Gelder and Dan Lungu and apparently the two main authors will encourage more contributors for a third edition. The authors are very much interested in demonstrating applications of extreme value theory using their Xtremes software and generously invite others to join in.

The structure and theme of the book has not changed. Section I on modeling and analysis has replaced the section on robust statistics with a section called heavy and fat-tailed distributions. The sections are slightly longer in the second edition. Chapter 2 has an additional section called the auto-tail-dependence function.

Part II on inference for parametric models includes a whole new chapter on Poisson Processes (Chapter 7). In Part III on multivariate methods, Chapter 9 on multivariate maxima includes a new section on the Gumbel-McFadden Model and Chapter 10 a new section on bivariate peaks over a threshold.

Part IV on topics in Hydrology, Insurance and Finance is totally revised and consists of Chapters 11-14 in place of the original Chapters 9-11. The old Chapters 9 and 10 are now Chapters 12 and 13 respectively.

In Part V there are again five case studies but they are totally new ones with the new authors that are acknowledged in the preface.

In the appendix they have replaced the description of the XPL programming language with the StatPascal language.

emphasizes applications using XTREMES software.......2002-01-29

The software XTREMES was introduced by Falk, Husler and Reiss in their 1994 book "Laws of Small Numbers: Extremes and Rare Events". That book was mainly theoretical and the software was in an MS-DOS version for PCs. This text was published in 1997. For this text they supply a Windows (3.1 , 95, NT) version on a CD ROM.

In this book the emphasis is on applications in insurance, finance, hydrology and other fields. The first 10 chapters develop the theory and teach the use of XTREMES presenting dialog boxes and descriptions. The text is divided into 5 parts. Part I deals with modeling and data analysis, part II covers statistical infrence for parametric models, in part III elements of multivariate analysis are introduced, part IV emphasizes the application areas and part V is a collection of case studies using XTREMES. There are five case studies. One presented by Reiss but other presented by notable researchers including Tai Hsing, Jurg Husler, Ana Ferreira, Edgar Kaufmann and Cornelia Hillgartner. The appendices provide additional details on XTREMES. This is a very unique text that is valuable to anyone interested in doing research or applications of extreme value theory. Includes coverage of the parametric bootstrap.

Book Description

For decades, the story of the American West has been told as a glorious tale of conquest and rugged individualism--the triumph of progress. But recently, a new school of historians has challenged this view, creating what is known as the "new western history," an approach that gives a central role to the environment, native peoples, and the concentration of power in the hands of a few. Foremost among these historians is Donald Worster. In Worster's writings, the western past emerges not as a march of Manifest Destiny but rather as an unfolding relationship between humankind and nature. In Under Western Skies, Worster provides an eloquent introduction to the changing traditions of western historical writing and then demonstrates his own approach through fascinating case studies. For example, he takes a hard look at the struggle by the Lakota to regain ownership of the Black Hills, examining not only the legal history of treaties and court cases but also the importance of the Black Hills in Indian religion and the way they have been mismanaged by the U.S. government. He discusses the cowboy in terms of the new ecology that arose from livestock ranching--the endless miles of fences, the changes in the environment wrought by extensive grazing, certain species of animals almost wiped out because they were considered a danger to sheep and cattle. But Worster's view of nature is not as simple or as, linear as for instance, Bill McKibben's stark picture in The End of Nature, a picture Worster argues against. From the mining ghost towns of the Rockies to the uprooted farm families of the Dust Bowl, nature sometimes wins the struggle. Even the Hoover Dam, he reminds us, may one day be overcome by the patient Colorado River. Under Western Skies both offers intriguing insights into important aspects of our history and instills a new appreciation for the place of nature, native peoples, and the struggles over money and power in the western past.

Under Western Skies : Nature & History in the American West

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Under Western Skies : Nature & History in the American West
Donald Worster
Manufacturer: Oxford University Press, Incorporated
ProductGroup: Book
Binding: Paperback
ASIN: B000O00KBK

Under Western Skies, Nature and History in the American West

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Under Western Skies, Nature and History in the American West
Donald Worster
Manufacturer: New York: Oxford Univ Press, 1992,
ProductGroup: Book
Binding: Hardcover
ASIN: B000OM8T20

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Under Western Skies: Nature and History in the American West
Donald Worster
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback
ASIN: B000OKADZ8

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