Microbial Genomics and Drug Discovery

Book Description

Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process. This comprehensive reference describes procedures to recognize common targets in various bacterial species for the design of broad-spectrum antibiotics and clearly illustrates the use of pathway tools in a genomics-based drug discovery project.

Book Description

Written for organic chemists, this all-new second edition offers an easy entry into the field of organotransition metal chemistry without requiring a background in inorganic chemistry. The book first covers the basics of transition metal chemistry and gives a practical introduction to the mechanisms by which organometallic reactions occur. The organic chemistry of transition metals is then presented by class of metal complex, with many examples of applications in the synthesis of natural products, pharmaceuticals, polymers, and materials. Ideal for advanced undergraduate and graduate students as well as all practicing synthetic organic chemists.

Customer Reviews:

An excellent textbook for chemists & graduated students.......2000-11-05

The growth of organometallics is amazing, so we want a systematic book to introduce the developments, and this one is very suitable. Hegedus introduced many new synthetic technology in this book, and they are very useful for chemists research work.

A great book.......2000-05-10

Hegedus has blended theory perfectly with synthetic utility of transition metals. The second addition has a lot more updated, state-of-art examples in synthesis.

Definitely an excellent resource.......2000-05-10

Hegedus does an excellent job of outlining the broad field of organometallic chemistry. He covers a vast range of topics, providing the reader with a strong background in the subject area. He utilizes current literature examples to demonstrate the use and importance of the topics presented. Overall, this is a very well written book, and a great reference.

Transition Metals in Organic Synthesis: A Practical Approach (The Practical Approach in Chemistry Series)

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Transition Metals in Organic Synthesis: A Practical Approach (The Practical Approach in Chemistry Series)

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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Book Description

This volume is designed to disseminate practical expertise in this important but practically demanding area of chemistry to undergraduate and postgraduate students in Universities and to researchers working in the chemical industry. The Chapter authors have considerable practical experience in the areas they cover and they are all intimately involved in the teaching of practical chemistry to University students. Topics include transition metal-promoted oxidations, palladium-catalysed carbon-carbon bond formation, ferrocene chemistry, applications of organoiron complexes in organic synthesis, applications of titanocene and zirconocene complexes in organic synthesis and arene chromium tricarbonyl chemistry. A Chapter on Schlenk techniques for handling air-sensitive compounds is also included.

Organic Synthesis Using Transition Metals (Postgraduate Chemistry)

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Organic Synthesis Using Transition Metals (Postgraduate Chemistry)
Roderick Bates
Manufacturer: Blackwell Publishing Limited
ProductGroup: Book
Binding: Hardcover

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ASIN: 1841271071

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This volume considers the ways in which transition metals, as catalysts and reagents, can be used in organic synthesis. It concentrates on the bond-forming reactions that set transition metal chemistry apart from classical organic chemistry.Transition metals open up new opportunities for synthesis, because their means of bonding and their reaction mechanisms differ from those of the elements of the s and p blocks. In the last decade, the subject has mushroomed. Established reactions are seeing both technical improvements and increasing numbers of applications. New reactions are being developed. The practicality of the subject is demonstrated by the large number of publications coming from the process development laboratories of pharmaceutical companies.The book is extensively referenced and so provides a convenient point of entry to the research literature.

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New Pathways for Organic Synthesis
H.M. Colquhoun , J. Holton , D.J. Thompson , and M.V. Twigg
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Alkene Metathesis in Organic Synthesis (Topics in Organometallic Chemistry)

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Alkene Metathesis in Organic Synthesis (Topics in Organometallic Chemistry)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Book Description

The tremendous progress in olefin metathesis achieved during the last decade can hardly be overestimated. Due to the development of a new generation of well defined and high-performance organometallic catalysts, this reaction is rapidly evolving into one of the most versatile tools for advanced organic chemistry, natural product synthesis, fine chemical production and polymer sciences. Written by some of the leading experts in this field, this monograph intends to familiarize the reader with the most exciting developments and frontiers in this flourishing field of chemistry research.

Comprehensive Organometallic Chemistry II : Transition Metal Organometallics in Organic Synthesis (Comprehensive Organometallic Chemistry II)

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Comprehensive Organometallic Chemistry II : Transition Metal Organometallics in Organic Synthesis (Comprehensive Organometallic Chemistry II)

Manufacturer: Pergamon
ProductGroup: Book
Binding: Hardcover

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ASIN: 0080423191

Book Description

This is a completely new volume, which comprehensively treats the use of transition metals in organic synthesis, with real emphasis on synthetically useful transformations on highly functionalized substrates. It is complete through to mid-1993 and each section has been written by an author who was responsible for the development of the chemistry involved.

Synthetic Methods of Organometallic and Inorganic Chemistry, Volume 10: Transition Metals, Part 4

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Synthetic Methods of Organometallic and Inorganic Chemistry, Volume 10: Transition Metals, Part 4

Manufacturer: Thieme Medical Publishers
ProductGroup: Book
Binding: Hardcover

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Synthetic Methods of Organometallic And Inorganic Chemistry: Transition Metals (Synthetic Methods of Organic Chemistry (Theilheime)

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Synthetic Methods of Organometallic And Inorganic Chemistry: Transition Metals (Synthetic Methods of Organic Chemistry (Theilheime)

Manufacturer: Georg Thieme Verlag
ProductGroup: Book
Binding: Hardcover

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Transition Metal Arene Pi-complexes In Organic Synthesis And Catalysis (Topics in Organometallic Chemistry)

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Transition Metal Arene Pi-complexes In Organic Synthesis And Catalysis (Topics in Organometallic Chemistry)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 354001604X

Book Description

Metal-arene pi-complexes show a rich and varied chemistry. The metal adds a third dimension to the planar aromatic compounds and coordination of a metal to an arene thus not only altering the reactivity of ring-carbons and substituents but also makes possible reactions that lead to chiral non-racemic products. This book, organized in nine chapters and written by leading scientists in the field provides the reader with an up-to-date treatise on the subject organized according to reaction type and use. It covers the wide spectrum of arene activation: from the electrophilic activation of h ⁶-bound arene by pi-Lewis acid metal complex fragments, to reactions of nucleophilic h ²-coordinated arene complexes. The preparation of complexes is detailed, as are the scope, limitations and challenges of reactions in contemporary pi-arene metal chemistry with special attention given to asymmetric transformations. The emphasis of the book is on transformations of interest to organic synthesis and on the use of the complexes as catalysts or as chiral ligands.
The book is written for academic and industrial researchers in organic, organometallic, and inorganic chemistry as well as for advanced chemistry students.

Transition Metal Organometallics for Organic Synthesis

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Transition Metal Organometallics for Organic Synthesis
F. J. McQuillin , D. G. Parker , and G. R. Stephenson
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Hardcover

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Solids subjected to sufficiently large loads undergo plastic strain that does not vanish after unloading. Limit analysis is used to find out whether a given loading is safe against capacity loss due to intensive plastic deformation. Over the past 25 years, the theory and methods of limit analysis have undergone substantial development. This book gives a clear and complete presentation of the state of the art of limit analysis, including:

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An intelligent and idiosyncratic antidote to the "definitive" lists of twentieth-century classics.

In Pure Pleasure, John Carey, one of Britain's most respected literary critics, introduces us to what he believes are the fifty most enjoyable books of the twentieth century based on sheer reading pleasure. Mixing fiction, nonfiction, and poetry, Carey includes literary heavyweights like James Joyce, Thomas Mann, and T. S. Eliot, as well as more populist writers like Arthur Conan Doyle, Kingsley Amis, and John Updike. Carey also discusses masterpieces like F. Scott Fitzgerald's The Great Gatsby and Günter Grass's The Tin Drum, alongside lesser-known works like D. H. Lawrence's Twilight in Italy and George Orwell's Coming Up for Air.

In a series of intelligent and fast-moving essays -- each devoted to a single book -- Carey mixes criticism, biography, and cultural context about each selection with illuminations on the author's inspiration and how each work was written. The end result is a book that no one who is passionate about reading should be without.

Customer Reviews:

An Accessible Introduction to 50 Good Books.......2005-11-08

This book collects the essays commissioned from Carey (editor, Oxford English professor, and accomplished author of studies on Dickens, Thackeray, Donne) by London's Sunday Times. The list of books he compiled is all 20th-century, limited to one book per author, and aims for balance between the decades. (That said, it's definitely weighted toward the first 2/3 of the century -- the '60s have four books, '70s have two, '80s have three, and the '90s also three.) In the introduction, Carey explains some of the rationale for his selections: "The list that I have put together is.... not chosen on grounds of literary 'greatness', the testimony they bear to the human spirit, or anything of that kind.... Instead I took pure reading-pleasure as my criterion -- the pleasure the books have given me, and the pleasure I hope others will get from being reminded of them, or perhaps introduced to them..." and similarly he decided to "omit books that gain their power more from their subjects more than their writing."

The resulting list of selections is a mix of 33 novels and short story collections, 10 poetry collections and 7 works of non-fiction. Most of authors will be instantly recognizable to anyone with more than a passing interest in 20th-century Western letters: Amis, Auden, Chesterton, Conan Doyle, Conrad, Eliot, Fitzgerald, Forester, Gide, Graves, Greene, Hardy, Huxley, Joyce, Kipling, Mann, Naipaul, Orwell, Sarte, Steinbeck, Waugh, Wells -- albeit with a few notable exceptions (no Faulkner, Hemingway, Nabokov). Those with a particular interest in female writers may be a little dismayed by their relative absence (five are included: Elizabeth Bowen, Katherine Mansfield, poetess Stevie Smith, Muriel Spark, and Sylvia Townsend Warner), but as Carey makes clear from the outset, it is a very personal selection.

Each selection is accorded a 3-4 page essay which combines concise summary with authorial context and insightful analysis. These benefit from Carey's expertise and clear writing, which manages to convey both his erudition and enthusiasm for each work. On the one hand, I found myself newly enriched by his comments on books I'd long ago read, such as "The Great Gatsby", "Brighton Rock", and "The Good Soldier Svejk". And on the other, I was greatly appreciative of Carey's discovery that "I found myself avoiding the thumping masterpieces, and going instead for less trumpeted and less familiar favorites..." Among the books I'll be seeking out at some point in the future are Bulgakov's "A Country Doctor's Notebook", Isherwood's "Mr. Norris Changes Trains", Mann's "Confessions of Felix Krull, Confidence Man", and Orwell's "Coming Up for Air". Easy to dip into, this is an excellent resource for the reader looking for an accessible introduction to some of the best of 20th-century writing.

Unpretentious tour of favorite books.......2004-07-15

I picked this book up after it was mentioned in a 'Reason' magazine article about James Joyce and Bloomsday celebrations. Carey writes well, has well-reasoned opinions, and is humane in his critical judgments. His list is less should-do and more want-to. I will return to it again and again when considering what to read next. Thank you, Mr. Carey!

Great reading for readers!.......2001-07-31

This is a truly enjoyable book. Carey discusses (or should that be: enthuses about) his personal favourites with a passion that makes one want to go out and read, or re-read, all of them. And he does so in a wonderfully concise and clear manner, never academic in tone.

This is a book for anybody who love reading, to read, but also to refer back to from time to time. I cannot but recommend it.

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Pure Pleasure: a Guide to the Twenieth Century's Most Enjoyable Books
John Carey
Manufacturer: Faber & Faber
ProductGroup: Book
Binding: Paperback
ASIN: B000NI7W1E

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