Epigenetics Protocols (Methods in Molecular Biology)

Book Description

A collection of state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer.

Telomeres, Second Edition
<br>
<i>Cold Spring Harbor Monograph Series 45</i> (Cold Spring Harbor Monograph Series)

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Very Up To Date Report on Current Research

Telomeres, Second Edition
Cold Spring Harbor Monograph Series 45 (Cold Spring Harbor Monograph Series)

Manufacturer: Cold Spring Harbor Laboratory Press
ProductGroup: Book
Binding: Hardcover

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Biology of Cancer

ASIN: 0879697342
Release Date: 2005-12-01

Product Description

An uptodate survey of the current exciting state of telomere biology. Telomeresspecialized structures found at the ends of chromosomes are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

Customer Reviews:

Very Up To Date Report on Current Research.......2006-03-17

It has been ten years since the first edition of this book. In that decade interest in telomeres has skyrocketed as a relation between telomeres and cancer has become more likely.

As is common with fields that are developing so rapidly, no 'standard' textbook has been written because it would become out of date so fast. Instead this book is a compendium of articles from researchers from around the world. Each of the articles has been peer reviewed and selected for this book by the editiors, each of whom is a pioneer in the field. The articles come from laboratories literally around the world, where ever the most important basic research is being conducted.

Cold Spring Harbor Laboratory Press is a very fast publisher. The basic material was finally collected for the book in July of 2005. By November of that year the book was in print. This means that the research being described is current to within half a year -- remarkably short timing for a published hardback book.

A cat called Telomere: The 1998 science columns of Walter R.T. Witschey, Ph.D

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A cat called Telomere: The 1998 science columns of Walter R.T. Witschey, Ph.D
Walter Robert Thurmond Witschey
Manufacturer: Gatewood Co
ProductGroup: Book
Binding: Unknown Binding

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ASIN: B0006RGAGA

Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA

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Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA
Catherine Brady
Manufacturer: The MIT Press
ProductGroup: Book
Binding: Hardcover

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Book Description

Molecular biologist Elizabeth Blackburn--one of Time magazine’s 100 âMost Influential People in the Worldâ in 2007--made headlines in 2004 when she was dismissed from the President's Council on Bioethics after objecting to the council's call for a moratorium on stem cell research and protesting the suppression of relevant scientific evidence in its final report. But it is Blackburn's groundbreaking work on telomeric DNA, which launched the field of telomere research, that will have the more profound and long-lasting effect on science and society. In this compelling biography, Catherine Brady tells the story of Elizabeth Blackburn's life and work and the emergence of a new field of scientific research on the specialized ends of chromosomes and the enzyme, telomerase, that extends them.

In the early stages of telomere research, telomerase, heralded as a potential cure for cancer and diseases related to aging, attracted the voracious interest of biotech companies. The surrounding hype succeeded in confusing the role of telemorase in extending the life of a cell with a mechanism that might extend the lifespan of an entire organism. In Brady's hands, Blackburn's story reveals much about the tension between pure and applied science, the politicking that makes research science such a competitive field, and the resourceful opportunism that characterizes the best scientific thinking.

Brady describes the science accessibly and compellingly. She explores Blackburn's struggle to break down barriers in an elite, male-dominated profession, her role as a mentor to other women scientists (many of whom have made their mark in telomere research), and the collaborative nature of scientific work. This book gives us a vivid portrait of an exceptional woman and a new understanding of the combination of curiosity, imaginative speculation, and aesthetic delight that powers scientific discovery.

Retrotransposition, Diversity and the Brain (Research and Perspectives in Neurosciences)

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Retrotransposition, Diversity and the Brain (Research and Perspectives in Neurosciences)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Book Description

This Fondation IPSEN Colloque Médecine et Recherche was devoted to the interface between the complexity of brain organization and function, the mechanisms for generating diversity and genetic mobility. The goal was to expand the current limits of research in neurobiology not only to the benefit of those interested in the cellular and molecular processes but also for the understanding of high-level cognitive functions and the understanding of complex mental diseases.

Telomerases, Telomeres and Cancer (Molecular Biology Intelligence Unit)

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Telomerases, Telomeres and Cancer (Molecular Biology Intelligence Unit)

Manufacturer: Springer
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Binding: Hardcover

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ASIN: 0306474379

Book Description

This volume provides broad insights to the most recent discoveries in telomere biology, with current applications in tumor diagnostics and future potentials in therapy. Special features of diverse organisms are presented, with ciliates, the "telomerase discoverer organisms"; yeasts, the "molecular genetisists' toy for eukaryotes"; including plants and insects as well. 28 chapters were written by a group of leading research scientists, working in the telomere/telomerase fields today. This book will be a core reference for any physician, scientist or "educated reader" with an interest in the exciting developments in this research field.

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The Telomere
David Kipling
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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Book Description

Telomeres are specialised structures at ends of linear chromosomes. They are involved in a wide range of genetic phenomena ranging from novel biochemistry to a potential role in human ageing and cancer. This book covers a number of diverse subjects including: the role of telomeres in nuclear organisation; telomere DNA sequence and unusual structures formed by telomeric sequences in vitro; replication of telomere sequences by telomerase and how this relates to various DNA sequence features; proteins that bind or interact with telomeres; the role of telomeres in programmed and spontaneous chromosome breakage; recent speculation on the relationship between telomere loss, aging and cancer; telomere position effects on replication and transcription; human telomere structure, genome analysis and genetic disease. This is the first book of its kind to cover this exciting and rapidly expanding field of molecular biology and genetics. It will provide an invaluable teaching tool, and introduction to the subject for newcomers to the field, and also act as an invaluable reference for established researchers.

Telomeres and Telomerase - Symposium No. 211

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this book will surely turning back the strands of time
it is very informative!

Telomeres and Telomerase - Symposium No. 211
CIBA Foundation Symposium
Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Hardcover

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Book Description

Telomeres and Telomerase Chairman: Sydney Brenner 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5??? to 3??? direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short stretches of nucleotide repeats using a portion of its integral RNA component as the template. Recently, much excitement has been generated by the suggestion that telomerase, or rather the absence of telomerase and the resultant loss of terminal DNA, is a cause of human ageing. The evidence for this is twofold: the telomeres of certain cells in culture shorten during their lifespan; and immortalization of cells is associated, at least in some cases, with the maintenance of telomeres and telomerase activity. The latter observation prompted the analysis of clinical samples from patients with cancer and the demonstration that, in contrast to normal somatic cells, malignant cells possess telomerase activity. This is a unique book. Not only does it contain the latest experimental results from an international group of experts, but it also includes critical examinations of the current evidence, and discussions that attempt to identify the central and underlying concepts of this rapidly expanding field.

Customer Reviews:

this book will surely turning back the strands of time.......1999-10-25

as a senior scientist, I couldn't write better book. this book reports on the discovery of an enzyme that slows down the aging process in every cell of our body. the authors found a pupular way to show how and why this remarkable enzyme works and the reader learns what the applications of this amazing discovery may be for everyone of us.

you may say the book cost a lot. well, if wrinkles is a past story. isnt it worth? this book might add years of happiness to your life. great writing ability. humur. intersting book.

it is very informative!.......1998-08-29

I readthis book and found some very basic questions answered on telomeres.This is a great book for people who are interested in knowing about telomeres.The discussions in it are very informative and make good reading.

Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing

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Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Book Description

This book provides an in depth review of our current knowledge on the role of telomeres and telomerase in ageing, disease and cancer. Telomere shortening results in telomere dysfunction, which represents one of the basic aspects of ageing contributing to the accumulation of DNA damage during ageing. The book describes cell intrinsic checkpoints (senescence and apoptosis) and environmental alterations that limit stem cell function during ageing and disease. The book focuses on experimental data in mouse models and cell lines and, in addition, provides and overview on telomere shortening in human diseases and ageing. The book also describes future directions in research on adult stem cell ageing, telomeres, and cancer. In addition, the book points to potential targets for molecular therapies aiming to improve regeneration and stem cell function during ageing or to impair cancer cell proliferation.

A special focus of the book is on adult stem cells. There is emerging evidence that adult stem cell ageing impairs organismal fitness and survival and contributes to cancer formation (cancer stem cells). The book summarizes basic mechanisms of adult stem cell ageing. Moreover, the authors describe consequences of telomere dysfunction on stem cell function involving cell intrinsic checkpoints as well as environmental alteration of the stem cell niche.

The above subjects appear to be of utmost importance to ageing researchers and physicians. Due to the advances in medicine, food supply and housing a growing percentage of humans reaches a long lifespan (>70 years). At this age molecular mechanisms of ageing limit organ maintenance, fitness and survival. A detailed understanding of the molecular mechanisms underlying the ageing process is essential to further improve quality of life and ‘health span’ in the ageing human populations.

In summary, this book provides an excellent basis for academic teachers, scientists, and students interested in the areas of stem cell ageing, telomeres & telomerase, regeneration, and cancer. In addition, the book is of interest for physicians since the development of molecular therapies targeting ageing stem cells represents a promising approach to improve regenerative reserve and organ function during ageing and could also serve to target cancer stem cells.

Telomeres and Telomerase: Methods and Protocols (Methods in Molecular Biology)

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Telomerase Book
Telomerase Book

Telomeres and Telomerase: Methods and Protocols (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 089603657X

Book Description

John A. Double and Michael J. Thompson have collected a critically important series of novel and essential techniques for studying telomeres and telomerase. These readily reproducible methods provide cutting-edge tools to identify, measure, and analyze telomeres, to determine telomerase expression at the RNA level, to determine telomerase activity, and to detect potential modifiers of this activity. The techniques for assaying telomerase activity range from standard radiological TRAP assays to nonradioactive methods, from non PCR-based methods to techniques using real-time PCR. Telomeres and Telomerase: Methods and Protocols provides the core array of productive techniques needed today to develop telomerase inhibitors or diagnostic/prognostic telomerase markers.

Customer Reviews:

Telomerase Book.......2002-11-09

This book should be called Telomerase Book. Very detailed and helpful on telomerase assays but nothing satisfactory on telomere assays actually there is not one single protocol on actual telomere length measurement (only one method for detection one for distribution).

If you research the activity go for it, is a good book but if you want information on the length like me this is not a book for you.

Telomerase Book.......2002-11-09

If you research the activity go for it, is a good book but if you want information on the length like me this is not a book for you.

Book Description

Based on the Third International Workshop Conference on Evolution Equations, Control Theory and Biomathematics, held in Hans-sur-Lesse, Belgium. The papers examine important advances in evolution equations related to physical, engineering and biological applications.

Evolution Equations, Control Theory, and Biomathematics (Lecture Notes in Pure and Applied Mathematics)

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Evolution Equations, Control Theory, and Biomathematics (Lecture Notes in Pure and Applied Mathematics)
Philippe Clement
Manufacturer: NY
ProductGroup: Book
Binding: Paperback
ASIN: B000MUD51E

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IAN FLEMING'S STORY OF CHITTY CHITTY BANG BANG! THE MAGICAL CAR

Manufacturer: Random House
ProductGroup: Book
Binding: Hardcover
ASIN: B000H3BF7W

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Chitty Chitty Bang Bang: The Magical Car
Ian Fleming
Manufacturer: Random House
ProductGroup: Book
Binding: Hardcover
ASIN: B000JWR8YU

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Ian Fleming's Story of Chitty Chitty Bang Bang! the Magical Car.
Al. Perkins
Manufacturer: Random House (Merchandising)
ProductGroup: Book
Binding: Hardcover

Magic & Wizards | Fantasy | Science Fiction & Fantasy | Subjects | Books
ASIN: 0394800532

Average customer rating:

Yes, it is by THAT Ian Flemming!

great for all ages

A wonderful story for all ages

Not the movie--even better!

A Delightful Ride!

Chitty Chitty Bang Bang: the magical car. Adventure number two (2). Illustrated by John Burningham.
Ian, and Burningham, John Fleming
Manufacturer: Jonathan Cape
ProductGroup: Book
Binding: Hardcover

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Bed-Knob and Broomstick (A Combined Edition of: "The Magic Bed-Knob" and "Bonfires and Broomsticks")

Chitty Chitty Bang Bang (Full Screen Edition)

Mary Poppins (Odyssey Classics)

The Borrowers

Mary Poppins Comes Back

ASIN: 0224608495

Customer Reviews:

Yes, it is by THAT Ian Flemming!.......2007-04-08

A wonderful book. I loved it as a child, and going back to read it as an adult I realize that there are a lot of things that I missed. I remember my teacher reading it aloud in class--wonderful!

The movie, although very nice, has only a superficial resemblance to the book. For one thing, it moves the time a generation or so back. For another, in the book both parents are alive, rather than Caracticus Pott's being a widower; consequently, there is no romance.

I could very well wish that a new movie be made, NOT a musical and following the original plot.

great for all ages.......2006-06-29

Just like when I was a kid at my moms knee listening to her read this to me I wsa again transported to another time. This audio is great. Kids and adults alike will fall inlove with this audio book. Some what diffrent than the movie staring Dick Van Dyke. which is always a welcome suprise.

A wonderful story for all ages.......2006-02-06

It is a charming and delightful story that you will love to read to your children. I read this book to my 6 year old. She loved it!! We both wish we could find more books about this wonderful family and car.

Not the movie--even better!.......2005-09-04

I remember the 1968 movie based on this novel fondly, but had never picked up the novel itself until just the other day. I was surprised at how different the book is. Although Chitty-Chitty-Bang-Bang herself is very similar in both, the plot of the story is much different. I enjoyed this simple little story, with Fleming's humorous asides, very much. Those asides reminded me of the "Series of Unfortunate Events" books I have read and I would be interested in learning if Lemony Snicket drew from Fleming's story style for his own series. This is a fun, quick story that most kids will enjoy. I do, however, fear that the admittedly crude illustrations in my original edition would not be as popular with modern children.

A Delightful Ride!.......2005-04-28

The story of Caractacus Pott, his family, and that wonderful magical car is one of the best children's stories you will ever read. Ian Fleming, the creator of James Bond, tells a fantastic story about Chitty Chitty Bang Bang, the magical flying car that can even turn into a boat! It's a delightful story, filled with crooks and gangsters, and you won't be sorry you bought this fantastic little book. Should be added to every child's bookshelf. Just delightful! The book is so much better than the movie, eliminating that silly Vulgaria story. If you want to read the story Ian Fleming intended, you'll have to buy the book. You won't be sorry.

Weekly reader children's book club presents Chitty Chitty Bang Bang: The magical car

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This is based on another edition, apparently now OOP.

Weekly reader children's book club presents Chitty Chitty Bang Bang: The magical car
Ian Fleming
Manufacturer: Random House
ProductGroup: Book
Binding: Unknown Binding

Magic & Wizards | Fantasy | Science Fiction & Fantasy | Subjects | Books
ASIN: B0007GPQNS

Customer Reviews:

This is based on another edition, apparently now OOP........2005-01-29

When most people think of Ian Fleming, they think of "James Bond." This is the only children's book he ever wrote, and one wishes that he wrote more.

Forget the Dick VanDyke film, which has very little resemblance to the book. (Not that it is a bad film, mind you, taken by itself.)

In the film, Mr. Potts was a widower; in the book, Mrs. P. was very much alive. They pushed the time-frame of the book about 75 years, also, and (aside from using the idea of the rehabilitated racecar that could convert into a boat or an airplane) the plot had very little resemblance to that of the book.

The story is fairly simple, but is well told, rather in the manner of a parent telling a bedtime story. The author is not afraid to use big words, but he explains them. I remember at about age eight (shortly after I heard my teacher read it out loud to us in school) I used the word 'transmogrification' at home; my Mother told me that wasn't a real word, and I said it was, and we looked it up in the dictionary--and there it was! (Mother wasn't a stupid or uneducated woman; she was a college professor.)

The book could be read TO a child as young as four or five, and could be read BY a child of nine or up.

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Chitty Chitty Bang Bang - Magical Car
Ian Fleming
Manufacturer: Random House
ProductGroup: Book
Binding: Unknown Binding
ASIN: B0000CMBBX

Chitty Chitty Bang Bang - The Magical Car

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Chitty Chitty Bang Bang - The Magical Car
Ian Fleming
Manufacturer: Scholastic
ProductGroup: Book
Binding: Paperback
ASIN: B000JKX6Y8

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CHITTY CHITTY BANG BANG THE MAGICAL CAR
IAN FLEMINGS
Manufacturer: RANDOM HOUSE, INC.
ProductGroup: Book
Binding: Hardcover
ASIN: B000OHK3MY

Chitty Chitty Bang Bang The Magical Car Adventure Number 1

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Chitty Chitty Bang Bang The Magical Car Adventure Number 1

Manufacturer: Jonathan Cape
ProductGroup: Book
Binding: Hardcover
ASIN: B000BJIY3K

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Chitty Chitty Bang Bang! The Magical Car
Ian Fleming
Manufacturer: Random House
ProductGroup: Book
Binding: Hardcover
ASIN: B000NTV19M

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