Nicotinic Acetylcholine Receptors: From Molecular Biology to Cognition (Odile Jacob)

Book Description

The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor.

Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition.

Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.

Book Description

"This outstanding reference presents the latest scientific findings concerning the synthesis, structure, thermodynamics, and physical and chemical properties of fluorine- and fluoride-carbon compounds elucidating their practical applications in lithium batteries, superhydrophobic composites, and the electrolytic production of elemental fluorine."

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Fluorine Chemistry at the Millennium

Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

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ASIN: 0080434053

Book Description

Hardbound. This volume brings together contributions by leading researchers covering a wide scope so characteristic of fluorine chemistry. It was in 1986 that the centennial of the isolation of fluorine by Moissan was celebrated, and much was said at the time about the impact of fluorine chemistry during its first century.

It is neither a textbook nor a structured exposition of fluorine chemistry as it stands at the beginning of the new millennium, but a monograph of historical character comprising personalized accounts of progress and events in areas of particular interest.

Book Description

Advances in Fluorine Science presents critical multidisciplinary overviews for areas in which fluorine and fluoride compounds have a decisive impact. The individual volumes of Advances in Fluorine Science are thematic, addressing comprehensively both the science and applications on topics including the Environment, Green chemistry, Medicine, Health & Life Sciences, New Technologies & Materials Science, Energy and the Earth Sciences.

For each subject the contributors will clearly inform the reader on the nature of the problem (if any) and on the solutions, combining knowledge from different scientific disciplines, that have been proposed to solve each issue.

This volume covers a wide scope of important issues about our atmospheric environment and contains contributions from both chemists and environmental scientists. Articles review the origin of fluorine-emissions either from natural or anthropogenic origin; the chemistry of fluorine- and halogen-based species in the atmosphere; the monitoring and characterization of atmospheric pollutants; new generations of halocarbons and improved destruction procedures of banned CFCs; the role of fluorides within both our geosphere: volcanic magmas and natural fluorine emissions, and effects on our biosphere: life cycle, plants and animals.

* Examines the role of fluorine and fluoride products in our environment: from the geosphere to the atmosphere through the biosphere
* Discusses the efforts of scientists and industry groups towards the improvement of environmental and sustainability issues
* Multidisciplinary contributions from chemists, geologists, biologists, environmentalists and industry staffs

Chemistry of Organic Fluorine Compounds II: A Critical Review (Acs Monograph)

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Chemistry of Organic Fluorine Compounds II: A Critical Review (Acs Monograph)

Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover

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Book Description

Provides complete coverage of the chemistry of organic fluorine compounds. Topics include fluorinating agents, fluorination processes, reactions of fluorinated compounds, modern analytical methods, and properties and applications of fluorinated compounds. Offers a critical review of the literature and provides over 4,500 references. Updates the 1976 volume Chemistry of Organic Fluorine Compounds.

Aromatic Fluorination (New Directions in Organic and Biological Chemistry)

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Aromatic Fluorination (New Directions in Organic and Biological Chemistry)
James H. Clark , David Wails , and Tony W. Bastock
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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Book Description

Academia and industry join forces in Aromatic Fluorination, as an expert from each domain contributes to this new text on fluorination of carbocyclic and heterocyclic rings. The book begins with a discussion of fluorine's unique combination of properties, including size, electronic effects, and hydrophobicity, as well as the historical development of its product applications. It explains methods for introducing fluorine into an aromatic ring, focusing on nucleophilic fluorine transfer reactions. The role of catalysts, solvents, and other variables are examined, and the scope and limitations of the methods are discussed. Of particular interest to those working in non-specialist laboratories, Aromatic Fluorination includes detailed descriptions of the new electrophilic routes to fluoroaromatics, in addition to traditional routes and alternative methods involving radical chemistry. Because one of the most important fluorine-containing substituent is CF3, the book explains routes to benzotrifluorides (ArCF3), including traditional industrial methods and modern alternatives employing C-1 halofluorocarbons and other fluoroaliphatics. An alternative to CF3 is CF3S, and several methods of synthesizing aromatic CF3S-containing molecules are described. Since the successful development and diverse applications of aromatic fluorine compounds have led to the search for new compounds and novel substituents, the incorporation of other substituents is also explored. Aromatic Fluorination concludes with discussion of the factors responsible for the successful development of pharmaceutical, agrochemical and liquid crystal applications and the potential for applications in high-performance polymers and other areas. This section also describes in detail important industrial aromatic fluorination processes and the relative merits of different process technologies and their costs.

Biomedical Frontiers of Fluorine Chemistry (Acs Symposium Series)

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Biomedical Frontiers of Fluorine Chemistry (Acs Symposium Series)

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0841234426

Book Description

Reviews recent research on fluorine-containing, biologically relevant molecules in biology and medicinal chemistry. Reports applications of bioactive organofluorine compounds as enzyme inhibitors, antithrombotics, anticancer agents, antiviral agents, antibacterials, central nervous system agents, and antifungals and antimalarial agents. Discusses the use of fluorine-containing amino acids as probes for investigating biomedical problems, including applications in fluorine-19 NMR, neurotransmission investigations, and fluorine-18 labeled tracers for positron emission tomography.

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Chemistry of organic fluorine compounds
Milos Hudlicky
Manufacturer: MacMillan
ProductGroup: Book
Binding: Unknown Binding

Chemistry of Tantalum and Niobium Fluoride Compounds

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Chemistry of Tantalum and Niobium Fluoride Compounds
Anatoly Agulyansky
Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

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ASIN: 0444516042

Book Description

Electronic, optical, mechanical and medical appliances are just a few examples of modern applications that use tantalum and niobium. In Chemistry of Tantalum and Niobium Fluoride Compounds, the author draws on thirty years' experience to produce the first ever monograph to systemize and summarize the data available on tantalum and niobium fluoride compounds. This comprehensive reference source offers a rich variety of study methodology and is invaluable to researchers examining the chemistry of fluorides, as well as teachers and students in chemistry and metallurgy.

* Collects the latest research on the chemistry of complex fluorides and oxyfluorides of Tantalum and Niobium.
* Covers both theory and application of Tantalum and Niobium Fluoride Chemistry
* Is suitable for tantalum and niobium producers, researchers studying the chemistry of fluorides, as well as teachers and students in chemistry and metallurgy

Experimental Methods in Organic Fluorine Chemistry

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Experimental Methods in Organic Fluorine Chemistry
Tomoya Kitazume , and Takashi Yamazaki
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 9056991221

Book Description

In the fields of biologically active materials and functional materials, fluorinated organic materials are becoming a focus of significant interest. Over the past decade synthetic methodologies and reagents in fluorine chemistry have been developed, especially stereocontrolled synthetic methods, enzymatic resolution to synthesize enantiomers, fluoromethylated reagents, and fluorination reagents. These methods have contributed to the opening of new pathways for fluorinated materials. However, few fluorinated materials have been put to commercial use. Furthermore, there remain problems to be solved, such as the handling of the materials, availability of reagents and selectivity (stereo-, regio-, and/or chemoselectivity). Research chemists, technical engineers, and graduate students in all branches of chemistry, pharmaceutics, and material science interested in fluorinated materials need to know detailed experimental procedures of how to synthesize the target fluorinated materials. This volume summarizes the chemical and microbial methods for obtaining functionalized fluorinated materials for use as building blocks; detailed experimental methods (reaction conditions, solvent, temperature, handling techniques, etc.); and the stereoview (possible absolute configuration) of the structures with spectral data. Mono-, di-, tri-, and polyfluorinated materials derived from fluorinating agents, fluoromethylated reagents and building blocks are summarized. A chemical name index, molecular formula index, and reagent index are also included. The publication of this monograph will provide access to the enormous possibilities in fluorine chemistry, biological material chemistry, and functionalized material chemistry.

Fluorine and the Environment : Agrochemicals, Archaeology, Green Chemistry & Water, Volume 2 (Advances in Fluorine Science)

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Fluorine and the Environment : Agrochemicals, Archaeology, Green Chemistry & Water, Volume 2 (Advances in Fluorine Science)

Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

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Book Description

Advances in Fluorine Science is a new book series presenting critical multidisciplinary overviews on areas in which fluorine and fluoride compounds have a decisive impact. The individual volumes of Advances in Fluorine Science are thematic, addressing comprehensively both the science and applications on topics including the Environment, Green chemistry, Medicine, Health & Life Sciences, New Technologies & Materials Science, Energy and the Earth Sciences.
In the present volume, the key-position of fluoro-products in agriculture is reviewed, since a large percentage of agro-chemicals and pesticides contain at least one fluorine atom. However, improvements in the use of fluorine-based products in agrochemicals cannot be developed without taking into consideration a safer environment, on both levels of greener synthesis routes and a reduction of the negative impact on plants and organisms. Within this scope, fluorine has a very peculiar place, since its high reactivity yields several advantages, for instance in by-passing various polluting multi-step reactions.
Fluorine-based materials are reviewed as efficient tools for protecting our cultural heritage. Also using up-to-date techniques such as ion beam analysis, this element can help relative dating applications, ranging from burial durations of archaeological bones and teeth to the determination of exposure ages of meteorites on the Antarctic ice shield.

* Providing an original approach of the complex relationships between chemistry and the environment
* Reviewing the key-position of fluoro-products in agriculture
* Multidisciplinary contributions from chemists, geologists, biologists, environmentalists and industry staffs

Book Description

This monograph presents a new theory for analysis, comparison and design of nonlinear smoothers, linking to established practices. Although a part of mathematical morphology, the special properties yield many simple, powerful and illuminating results leading to a novel nonlinear multiresolution analysis with pulses that may be as natural to vision as wavelet analysis is to acoustics. Similar to median transforms, they have the advantages of a supporting theory, computational simplicity, remarkable consistency, full trend preservation, and a Parceval-type identity.

Book Description

A master of naturalism, Theodore Dreiser brought the American novel into the twentieth century. Fascinated by the city street, its parade of fashion and its threat of poverty and degradation, his journalistic eye lets us see as they were first seen the now familiar realities of modern living. "Sister Carrie" traces the fate of a small-town girl drawn into the brutal metropolitan worlds of Chicago and New York, and Sinclair Lewis called it "the first fresh air since Mark Twain and Whitman." "Jennie Gerhardt"'s vital but naive heroine emerges superior to the succession of men who exploit her. With honest emotion and respect for unvarnished truth, "Twelve Men" muses on the exemplary lives of ordinary men in search of lasting values with which to face the new century. Together, these three works exemplify the energy, originality, and genius of one of the great modern American writers.

Sister Carrie; Jennie Gerhardt; Twelve Men.

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Sister Carrie; Jennie Gerhardt; Twelve Men.
Theodore Dreiser
Manufacturer: see notes for publisher info
ProductGroup: Book
Binding: Hardcover
ASIN: B000M43MYU

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