Evolutionary Quantitative Genetics

Book Description

This new textbook in quantitative genetics incorporates an evolutionary viewpoint, combining the theoretical basis of quantitative genetics with respect to evolution in natural populations and various statistical methods of analysis. Topics of current research such as genetic correlation and phenotypic plasticity are included. The book addresses the current problems in quantitative genetic evolutionary theory and presents the most commonly used methods of analysis.

Basic Concepts in Population, Quantitative, and Evolutionary Genetics

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Basic Concepts in Population, Quantitative, and Evolutionary Genetics
James G. Crow
Manufacturer: W.H. Freeman & Company
ProductGroup: Book
Binding: Paperback

General | Evolution | Science | Subjects | Books

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clear reading for beginners
Molecular Evolution and Phylogenetics by Masatoshi Nei, Sudhir Kumar
A valuable addition
OK, until something better comes along
Top in its Field

Molecular Evolution and Phylogenetics
Masatoshi Nei , and Sudhir Kumar
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0195135849

Book Description

During the last ten years, remarkable progress has occurred in the study of molecular evolution. Among the most important factors that are responsible for this progress are the development of new statistical methods and advances in computational technology. In particular, phylogenetic analysis of DNA or protein sequences has become a powerful tool for studying molecular evolution. Along with this developing technology, the application of the new statistical and computational methods has become more complicated and there is no comprehensive volume that treats these methods in depth. Molecular Evolution and Phylogenetics fills this gap and present various statistical methods that are easily accessible to general biologists as well as biochemists, bioinformatists and graduate students. The text covers measurement of sequence divergence, construction of phylogenetic trees, statistical tests for detection of positive Darwinian selection, inference of ancestral amino acid sequences, construction of linearized trees, and analysis of allele frequency data. Emphasis is given to practical methods of data analysis, and methods can be learned by working through numerical examples using the computer program MEGA2 that is provided.

Customer Reviews:

clear reading for beginners.......2007-10-05

this book is realy straightforward, very well-written and really explains the oncept in a very clear way. Excellent choice for non-specialists.

Molecular Evolution and Phylogenetics by Masatoshi Nei, Sudhir Kumar.......2007-03-09

Overall it is a good and complete book on Molecular Evolution, and basic DNA analysis techniques.

A valuable addition.......2003-11-26

I don't look for any one book to answer all my questions. This one carries its weight, though, and maybe a bit more.

The first section gives the clearest and most detailed description of nucleotide sequence comparisons I've seen. I'm no biologist, but it really got me thinking about some new ways to talk about substitution matrices.

The bulk of the book covers what I hoped for originally: phylogenetic trees. The authors choose an unusual approach - it doesn't quite meet the authors' initial promise of math-minimization, but doesn't climb too far up the ivory tower, either. I find it a very practical, usable level of presentation. I'd be nervous about going beyond their formulas, since the math for real understanding isn't all there. Still, the phylogeny discussion covers a lot of material, and covers it well enough for me to write programs about most of it.

The final section addresses population genetics. I have nothing against population genetics, it just never seemed to point where I'm headed. Nei and Kumar corrected my mis-impression. Population gentics is the background model, the null hypothesis, behind the functions that score population differences. It really shows what happens when the tree of life branches out.

The book has some minor weaknesses. It emphasizes nucleotide sequences at the expense of peptides; I can't fault an author for writing what they want as opposed to what I want. On page one, the authors decline an intensely mathematical approach. By page 25, they're up to Poisson and gamma distances. The typography make the section breaks into a "Where's Waldo" experience. Nei's favorite author, based on citations, is Nei. Well, false modesty is no virtue. This book seems authoritative and Nei seems to be an authority, maybe not just in Nei's opinion.

This book really has given me a lot more to work with than most. Education isn't cheap these days, and this book is very educational. I just hope no one asks me to lend it any time soon.

OK, until something better comes along.......2003-02-20

Nei and Kumar's "Molecular Evolution and Phylogenetics" is basically an updated version of Nei's 1987 "Molecular Evolutionary Genetics" book. Accordingly, attention is shifted to reviewing many recent advances in methods of phylogenetic inference with an obvious bias towards distance methods, particularly those which the senior author devised. In fairness, they give decent coverage to the more popular parsimony and likelihood methods as well. The great strength of the book is the number of real examples used to illustrate properties of the methods, and their focus on statistical methodology without miring the reader in detailed mathematics. The disappointment is that while breadth of coverage is tolerable, depth is lacking. Expanding their views on the shortcomings of likelihood in choosing tree topology and likelihood ratio-tests in choosing models of sequence evolution would have been most enlightening, particularly as these issues have been brushed lightly aside by phylo-likelihoodists. Other methods (Hadamard transformations, Bayesian phylogenetic inference) were absent altogether. Further the chapter on molecular clocks was disappointing--old 1980s controversies were rehashed, while there was nothing on methods that relax the assumption of rate constancy while still allowing divergences to be dated. Admittedly some of this is very new and research is ongoing, but there isn't even a hint of these developments in this chapter. Another plus though is the addition of a chapter on inferring ancestral states of molecular sequences.

Unlike Molecular Evolutionary Genetics, far too little of the book is devoted to methods at the population level, and what is there again smacks of state-of-the-art 15-20 years ago. I was hoping for much more coverage of microsatellite and AFLP data. There was very little for either, while now rarely-used RFLPs were given extensive coverage.

In short, this book was too short, particularly for the price, and I almost gave it 3 stars rather than 4. However, if you are a phylogeneticist, you will probably want to have this book on your shelf. A lighter introduction for the uninitiated would be Rod Page's "Molecular Evolution" or Graur and Li's "Fundamentals of Molecular Evolution". However, my hopes for a good comprehensive text and reference on phylogenetic methods now rest on publication of Joseph Felsenstein's "Inferring Phylogenies".

Top in its Field.......2000-09-21

This book is an excellent text and reference for both graduate students and faculty. It covers several topics in molecular evolution and phylogenetic analysis, as the title suggests. It stands as a unique contribution because the authors explain the mathematical and conceptual framework of a given topic in molecular evolution or phylogenetic analysis and give subsequent examples to show how various analytical methods can be applied to the study of that topic. In that context, the explanation of concepts was exceptionally clear, which made it easy to understand potentially difficult subject matter. This book is highly recommended to those wishing to study the analysis of genes and proteins in an evolutionary framework.

Book Description

The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including...

New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines
New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique
Expanded coverage of the unexpected side reactions that occur with protective groups
New chart covering the selective deprotection of silyl ethers
3,100 new references from the professional literature

The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.

Customer Reviews:

glad i bought it.......2007-08-31

i'm do organic synthesis. i reference this one once a week on average. it's the first stop whenever a protecting group questions comes up.

A must have for any synthetic laboratory.......2006-04-27

There are other protecting group books out there but I found this one to be the most comprehensive and easy to use.

must have.......2006-02-24

if you are synthetic chemist you ought to have this book with you

Protecting my thesis.......2004-08-15

This book contains methods for the installation and removal of practically every protecting group you can think of, and likely some you've never encountered. Most methods are referenced to articles containing representative procedures, saving valuable time scouring the literature. It is compact, well-organized and reasonably priced. Along with March's Advanced Organic Chemistry, this book is a must have for any organic chemist.

The Book Will be Your Bible in Lab.......2002-02-04

If you doing any sort of organic chemistry in the lab, you will really get your hands into this handy reference on protecting groups. The book neatly organized into functional groups and their protecting groups. A Primer for organic chemists. It will save you zillion hours of researching for papers/references on the appropriate protecting groups used in reactions.

Protecting Groups (Thieme Foundations of Organic Chemistry Series)

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Protecting Groups (Thieme Foundations of Organic Chemistry Series)
Philip J. Kocienski
Manufacturer: Thieme Medical Publishers
ProductGroup: Book
Binding: Hardcover

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ASIN: 0865779937

Protecting Group Chemistry (Oxford Chemistry Primers)

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Protecting Group Chemistry (Oxford Chemistry Primers)
Jeremy Robertson
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

General & Reference | Chemistry | Science | Subjects | Books

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Advanced Organic Chemistry, Fourth Edition - Part B: Reaction and Synthesis (Advanced Organic Chemistry / Advanced Organic Chemistry)

ASIN: 0198502753

Book Description

Protecting Group Chemistry provides an overview of the general methods that are used to block the reactivity of - i.e. protect - specific functional grops thus allowing others, present within the same molecule, to be manipulated unambiguously. An introductory chapter outlines protecting group strategy, relevant aspects of functional group reactivity, temporary protection, and introduces the concept of protecting group devices as an aid to unifying the wide range of available methods. The rest of the book is divided on the basis of broad classes of the experimental conditions that lead to cleavage of each protecting group (acid/electrophile, base/nucleophile, oxidising or reducing agent). The treatment differs from traditional texts in that it places the emphasis on making a connection between the fundamental mechanisms of organic chemsitry - ionisation, substitution, addition, elimination, oxidation and reduction, etc. - and how a particular protecting group can best be selected in a given situation.

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Protective Groups in Organic Chemistry

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

The development and analysis of electrochemical manipulation of protective groups

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The development and analysis of electrochemical manipulation of protective groups
Amy Cathryne Almon
ProductGroup: Book
Binding: Unknown Binding

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PROTECTIVE GROUPS IN ORGANIC CHEMISTRY

Manufacturer: Plenum Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000G3JP4S

Book Description

"A treatise on finite difference ineuqalities that have important applications to theories of various classes of finite difference and sum-difference equations, including several linear and nonlinear finite difference inequalities appearing for the first time in book form."

Integral and Finite Difference Inequalities and Applications, Volume 205 (North-Holland Mathematics Studies)

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Integral and Finite Difference Inequalities and Applications, Volume 205 (North-Holland Mathematics Studies)
B. G. Pachpatte
Manufacturer: North Holland
ProductGroup: Book
Binding: Hardcover

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ASIN: 0444527621

Book Description

The monograph is written with a view to provide basic tools for researchers working in Mathematical Analysis and Applications, concentrating on differential, integral and finite difference equations. It contains many inequalities which have only recently appeared in the literature and which can be used as powerful tools and will be a valuable source for a long time to come. It is self-contained and thus should be useful for those who are interested in learning or applying the inequalities with explicit estimates in their studies.

- Contains a variety of inequalities discovered which find numerous applications in various branches of differential, integral and finite difference equations.

- Many inequalities which have only recently discovered in the literature and can not yet be found in bother book.

- A valuable reference for someone requiring results about inequalities for use in some applications in various other branches of mathematics.

- Will be of interest to researchers working both in pure and applied mathematics and other areas of science and technology, and it could also be used as a text for an advanced graduate course.

- Contains a variety of inequalities discovered which find numerous applications in various branches of differential, integral and finite difference equations
- Valuable reference for someone requiring results about inequalities for use in some applications in various other branches of mathematics
- Highlights pure and applied mathematics and other areas of science and technology

Inequalities for Finite Difference Equations (Pure and Applied Mathematics (Marcel Dekker))

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Inequalities for Finite Difference Equations (Pure and Applied Mathematics (Marcel Dekker))
B.G. Pachpatte
Manufacturer: NY
ProductGroup: Book
Binding: Hardcover
ASIN: B000MU9HUW

Report - State University of New York at Stony Brook, College of Engineering

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Report - State University of New York at Stony Brook, College of Engineering
David A Levine
Manufacturer: State University of New York at Stony Brook, College of Engineering
ProductGroup: Book
Binding: Unknown Binding
ASIN: B0007EE5YG

Book Description

Written in a series of letters to the daughter of a friend, Love and Friendship tells of a young girl’s path to betrayal, by way of a seemingly ecstatic marriage. It is accompanied by The Three Sisters, another expertly crafted epistolary novel. When a noble youth arrives unannounced to request the hand of the matchless Laura, it seems their future is one of contentment and bliss—that is until his family learn of the marriage and, one by one, reject the new bride. Such begins the series of unspeakable events that make up Laura’s lot in life. But tragedy and comedy here go hand in hand as Austen delivers a stringent satire on drawing-room society, brilliantly heralding her later masterpieces.

Customer Reviews:

A Very Interesting Glimpse into Austen: The Writer and The Person.......2007-07-09

This book is almost identical to the original but it has an introduction by Fay Weldon. It is a collection of short stories, drama, humor, and other works written by Jane Austen at least a decade before her major novels. It is a series of letters and other works that Austen wrote, and they show a free spirited Austen, quite unlike her formula books that came later. As a read this is not what one would call great literature, but it is worthwhile to see a young Jane Austen writing without constraints, and writing as a young woman years before her fame.

As background information, I have read all of Austen's novels and I have read various analyses of Austen's work. Jane Austen's formula for success was to write a novel about of a financially disadvantaged young woman who meets and marries a wealthier man. The exception is her novel "Emma" where the protagonist has her own means. There are no axe murderers in an Austen novel or any nasty elements. Her stories take place in small English towns and they all have a variety of characters including a few willful women and usually one male rogue.

"Pride and Prejudice" is Jane Austen's finest novel. That book is the perfect balance of story, prose, structure, and interesting characters. It evokes many emotional responses in the reader. That novel is among the greatest novels of all time on par with for example Flaubert's "Madame Bovary" or Tolstoy's "Anna Karenina." From a strictly literary point of view, "Mansfield Park" is the most complicated and sophisticated literary work penned by Austen. Many like "Emma" as well.

The present work pre-dates her success and one can view it as her practicing her craft or simply developing as a writer. She will surprise most with the amount of humor that she manages to inject into the stories. The stories are short, some less than a page. Also, she has written bits of drama and humorous pieces which are included. I liked her brief humorous descriptions of the various kings and queens of England.

Most Austen fans will think the pieces to be very interesting but short. In any case, we see a completely different Austen here, and she writes with few self imposed limits. It is nothing like her later writings which tend to follow a formula.

As a note, the text is available free on line at the Gutenberg Project, and since it is so short it can be easily down-loaded.

Invaluable Glimpse.......2006-09-20

This edition of Love and Friendship includes the short epistolary novella bearing the same name, another short epistolary novella called Three Sisters, and five short stories written in letter form called A Collection of Letters. Jane Austen has been criticized for her lack of imagination, epsecially by her contemporaries. This is not so in her early work! This volume, written in her teens, indicates quite a healthy imagination. The plot of Love and Friendship is ridiculously silly and the heroine less than honorable, but Jane Austen's intelligence and wry sense of humor are more than apparent. Also, readers familiar with Jane Austen's more famous works will recognize the genesis of many characters and ideas in this volume that are fleshed out more fully in her later works. The mother, over-eager to marry off her daughters, in Three Sisters bears a strong resemblance to Mrs. Bennet in Pride and Prejudice. There is also a precursor to the hypocritical Lady Catherine de Bourgh in "Letter the Third" in A Collection of Letters. Love and Frienship is an invaluable glimpse into the child mind of one of the most cherished authors in literature.

Love and Friendship Review.......2004-03-03

I found the style in which Jane Austen writes very entertaining and captivating. The use of letters to describe all the events in the novel that the main character Laura experiences or hears from her friends Marianne and Isabel. This novel is increadible especially because Jane Austen wrote it at the age of 14, when weighing it against her other sucessful novels, this is not her best piece. I recommend it to any reader who is willing to appreciate the language over the substance.

Love and Friendship And Other Early Works

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A Very Interesting Glimpse into Austen: The Writer and The Person

Love and Friendship And Other Early Works
Jane Austen
Manufacturer: Women's Press, Ltd. (UK)
ProductGroup: Book
Binding: Paperback

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ASIN: 0704346672

Book Description

"Love and Friendship" collects Jane Austen's earliest writings, the "Juvenilia," not published in her lifetime. Immensely funny and remarkably sophisticated, their unerring accuracy has not diminished in 200 years.

Customer Reviews:

A Very Interesting Glimpse into Austen: The Writer and The Person.......2007-07-09

This is a collection of short stories, drama, humor, and other works written by Jane Austen at least a decade before her major novels. It is a series of letters and other works that Austen wrote, and they show a free spirited Austen, quite unlike her formula books that came later. As a read this is not what one would call great literature, but it is worthwhile to see a young Jane Austen writing without constraints, and writing as a young woman years before her fame.

As background information, I have read all of Austen's novels and I have read various analyses of Austen's work. Jane Austen's formula for success was to write a novel about of a financially disadvantaged young woman who meets and marries a wealthier man. The exception is her novel "Emma" where the protagonist has her own means. There are no axe murderers in an Austen novel or any nasty elements. Her stories take place in small English towns and they all have a variety of characters including a few willful women and usually one male rogue.

"Pride and Prejudice" is Jane Austen's finest novel. That book is the perfect balance of story, prose, structure, and interesting characters. It evokes many emotional responses in the reader. That novel is among the greatest novels of all time on par with for example Flaubert's "Madame Bovary" or Tolstoy's "Anna Karenina." From a strictly literary point of view, "Mansfield Park" is the most complicated and sophisticated literary work penned by Austen. Many like "Emma" as well.

The present work pre-dates her success and one can view it as her practicing her craft or simply developing as a writer. She will surprise most with the amount of humor that she manages to inject into the stories. The stories are short, some less than a page. Also, she has written bits of drama and humorous pieces which are included. I liked her brief humorous descriptions of the various kings and queens of England.

Most Austen fans will think the pieces to be very interesting but short. In any case, we see a completely different Austen here, and she writes with few self imposed limits. It is nothing like her later writings which tend to follow a formula.

As a note, the text is available free on line at the Gutenberg Project, and since it is so short it can be easily down-loaded.

The Flower of Friendship: A Renaissance Dialogue Contesting Marriage

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The Flower of Friendship: A Renaissance Dialogue Contesting Marriage
Edmund Tilney
Manufacturer: Cornell University Press
ProductGroup: Book
Binding: Hardcover

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Book Description

Edmund Tilney dedicated to Queen Elizabeth in 1568 a spirited dialogue concerning appropriate behavior in marriage. Extraordinarily popular for a generation following its first publication, it is available here for the first time in a critical edition that includes a comprehensive essay by Valerie Wayne.

Love & Friendship and Other Early Works Now First Published from the Original Ms. By...

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Love & Friendship and Other Early Works Now First Published from the Original Ms. By...
Jane. (Preface By G. K. Chesterton). Austen
Manufacturer: New York: Frederick A. Stokes, (1922).
ProductGroup: Book
Binding: Hardcover
ASIN: B000MACY3Y

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Love And Friendship And Other Early Works
Jane Austen
Manufacturer: Paperbackshop.Co.UK Ltd - Echo Library
ProductGroup: Book
Binding: Paperback

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ASIN: 1846372267

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Love and Friendship and Other Early Works
Jane Austen
Manufacturer: Barnes & Noble
ProductGroup: Book
Binding: Paperback

Classics | General | Literature & Fiction | Subjects | Books

Love and Friendship and Other Early Works (Large Print)

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Love and Friendship and Other Early Works (Large Print)
Jane Austen
Manufacturer: Echo Library
ProductGroup: Book
Binding: Hardcover

Classics | General | Literature & Fiction | Subjects | Books

Book Description

This large print title is set in Tiresias 16pt font as recommended by the RNIB.

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Love and friendship, and other early works
Jane Austen
Manufacturer: Folcroft Library Editions
ProductGroup: Book
Binding: Unknown Binding

Love and friendship [sic] and other early works

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Love and friendship [sic] and other early works
Jane Austen
Manufacturer: Norwood Editions
ProductGroup: Book
Binding: Unknown Binding

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