Biology of Aging: Observations and Principles

Book Description

Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: DT Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. DT A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. DT Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. DT Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. DT Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. DT Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 and 14-9), whose meanings are elucidated as the reader progresses through the book.

Customer Reviews:

Biology of Aging: Observations & Principles.......2006-03-09

It was exactly the edition I needed for my Biology of Aging course. It was delievered on time by Amazon

WOW!.......2002-10-18

I got this book because I used to do work on the author's lab and I was amazed by the work they were pursuing there.
I have read other bio textbooks, but what strikes me most about this one is that if you really just want to read one, this one has got it all. It is a complete survey, of all that is known and being studied currently on the topic of aging. From how to study aging to the goals of society in aging to everything inbetween. From the stuff that works, to might works, to absolutely does not, this is an excellent overview of the field.

BIOLOGY OF AGING:OBSERVATIONS & PRINCIPLES 3E

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BIOLOGY OF AGING:OBSERVATIONS & PRINCIPLES 3E
ARKING
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback
ASIN: B000OKQHW6

Book Description

This revision brings the reader completely up to date on the evolving methods associated with increasingly more complex sample types analyzed using high-performance liquid chromatography, or HPLC. The book also incorporates updated discussions of many of the fundamental components of HPLC systems and practical issues associated with the use of this analytical method. This edition includes new or expanded treatments of sample preparation, computer assisted method development, as well as biochemical samples, and chiral separations.

Customer Reviews:

A great book - information overload.......2002-07-16

This is a very useful reference to have if you work extensively on HPLC. I find its of more use to understand concepts ...there is a lot of information here.

Which means - if you are looking for a solution to a problem and you want to research separation theory - a great book.

If your looking for a quick fix to an HPLC problem - not as good. This is a detailed, extensive and well written text on HPLC Method development - wish there was more on validation here though.

Plactical and Rational method Development!.......2000-03-15

Rational Method development for HPLC is resented. Instruction of rational development of 3-solvent separation system is excellent. This book also has useful know-hows and tools in practical laboratory experiments, such as strength of hydrogen bonding of base silica and nomograph for estimation of "solvent strength" for reversed phase HPLC.

an excellent book on pratical HPLC.......1998-01-20

The book is useful for gerenal operator who are both novice and expert. It do is pratice. It's better give another chapter for troubleshooting and maintence.

LC/MS Applications in Drug Development (Wiley - Interscience Series on Mass Spectrometry)

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LC/MS Applications in Drug Development (Wiley - Interscience Series on Mass Spectrometry)
Mike S. Lee
Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Hardcover

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ASIN: 0471405205

Book Description

Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include:

Proteomics
Glycoprotein Mapping
Natural Products Dereplication
Lead Identification Screening
Open-Access LC/MS
In Vitro Drug Screening

Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.

Download Description

Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include:

-Proteomics
-Glycoprotein Mapping
-Natural Products Dereplication
-Lead Identification Screening
-Open-Access LC/MS
-In Vitro Drug Screening

Book Description

Describes analytical methods development, optimization and validation, and provides examples of successful methods development and validation in high-performance liquid chromatography (HPLC) areas. The text presents an overview of Food and Drug Administration (FDA)/International Conference on Harmonization (ICH) regulatory guidelines, compliance with validation requirements for regulatory agencies, and methods validation criteria stipulated by the US Pharmacopia, FDA and ICH.

Customer Reviews:

Limited scope.......2007-09-30

I have to admit being a bit disappointed with this book. The content is sound, based to a large extent on ICH guidance, and for the most part, applies concepts to HPLC analysis. The actual text begins on p17 and ends on p 83, with an average words/page <250 (there are likely less than 16000 words in the entire text). So my rating is biased by what I consider a poor value in terms of cost/content. By way of comparison, the ICH Q2A and Q2B comprise almost 3700 words.

Although the book focuses on HPLC, the title concept also applies to other analytical methods (immunoassays, bioassays, mass spec., flow cytometry, etc.) There is clearly more to be learned on this topic. This text may be considered an intorductory primer, or a concise summary.

In retrospect, I would preferred to have spent more money to receive a more thorough text with applications in more diverse methods.

Great Introduction.......2006-10-12

This book is a very good basic (and comparatively inexpensive) introduction to the terms and definitions of method validation. Certainly worth the price until the next edition comes out in early 2007.
Protocol sugestions, and the bibliography are worth the price alone.

Analytical Method Development and Validation.......2006-07-24

Very general description of the method validation process. This book could only be the first step in undestanding of the general requirements for the method validation process. To deepen one's knowledge, the reader should choose the books (e.g. Development and Validation of Analytical Methods by Christopher Riley) which are focused on explaining the concept from the scientific prospective.

Chromatography and Separation Chemistry: Advances and Developments (Acs Symposium Series)

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Chromatography and Separation Chemistry: Advances and Developments (Acs Symposium Series)

Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover

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Book Description

Highlights exciting developments in the science of chromatography and separations. Provides a unified theory to explain the manner of sorption in various forms of chromatography. Explores selectivity in reversed-phase HPLC, characterization of bonded-phases, relationship of column-packing
structure and performance, variability of reversed-phase packing materials, and the differences between silica-based reversed-phase and poly(styrene-divinylbenzene) columns. Includes a special section on computerization in chromatography. Organic chemists, theorists, and bioscience researchers will
find this work a stimulating, timely look at the science of chromatography.

Computer-Assisted Method Development for High-Performance Liquid Chromatography (Journal of Chromatography Library)

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Computer-Assisted Method Development for High-Performance Liquid Chromatography (Journal of Chromatography Library)
Joseph L. Glajch
Manufacturer: Elsevier Science Ltd
ProductGroup: Book
Binding: Paperback

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ASIN: 0444887482

Contemporary Practice of Chromatography (Developments in mineral processing)

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Contemporary Practice of Chromatography (Developments in mineral processing)
Colin F. Poole , and Sheila A. Schuette
Manufacturer: Elsevier Science Ltd
ProductGroup: Book
Binding: Hardcover

Chromatography | Chemistry | Science | Subjects | Books
ASIN: 0444424105

Current Developments in the Clinical Applications of Hplc, Gc, and MS: [Proceedings of a Symposium Held at the Clinical Research Centre, Watford Roa (Clinical Research Centre symposium ; no. 1)

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Current Developments in the Clinical Applications of Hplc, Gc, and MS: [Proceedings of a Symposium Held at the Clinical Research Centre, Watford Roa (Clinical Research Centre symposium ; no. 1)

Manufacturer: Academic Pr
ProductGroup: Book
Binding: Hardcover

Development of a rapid high performance liquid chromatography assay for the determination of dopamine in retinal tissue utilizing a simple extraction procedure : (Dissertation)

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Development of a rapid high performance liquid chromatography assay for the determination of dopamine in retinal tissue utilizing a simple extraction procedure : (Dissertation)
Edward Robert Limowski
Manufacturer: ProQuest Information and Learning
ProductGroup: Book
Binding: Digital

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Citation Details

Distributed by ProQuest Information and Learning

Developments in Chromatography (Developments Series)

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Developments in Chromatography (Developments Series)

Manufacturer: Applied Science Publishers
ProductGroup: Book
Binding: Hardcover

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Book Description

An advanced reference containing 21 selected or consolidated papers presented at an international conference in April 1988 at Tunxi (now Hunangshan), China. Contains recent, previously unavailable findings of Chinese mathematicians; discusses problems, results, and proving methods of combinatorial d

Amazon.com

Alice Walker, author of The Color Purple, is an international activist and self-professed womanist. This pleasing collection of short essays amounts to a very personal stroll through her psyche. Sharing touchstones and demons, she serves up a spirited defense of Winnie Mandela, accused of taking part in kidnapping and torture; a quest to mark the grave of Zora Neale Hurston, an "African AmerIndian" folklorist who chronicled the lives of Southern American blacks in the 1920s and '30s; poignant, angry witnesses at a conference in Ghana devoted to stopping female genital mutilation; and life lessons her daughter taught her. Walker's opinions are enriched by her poetry and highlighted by the whimsical phrases and titles with which she frames serious subjects.

Book Description

In Anything We Love Can Be Saved, Alice Walker writes about her life as an activist, in a book rich in the belief that the world is saveable, if only we will act. Speaking from her heart on a wide range of topics--religion and the spirit, feminism and race, families and identity, politics and social change--Walker begins with a moving autobiographical essay in which she describes her own spiritual growth and roots in activism. She goes on to explore many important private and public issues: being a daughter and raising one, dreadlocks, banned books, civil rights, and gender communication. She writes about Zora Neale Hurston and Salman Rushdie and offers advice to Bill Clinton. Here is a wise woman's thoughts as she interacts with the world today, and an important portrait of an activist writer's life.

Customer Reviews:

Pagan to its Core!.......2006-12-04

This is one of the most wonderful books I have ever read. Anybody who wants to know anything about the soul of Paganism should burn all of their "So You Want to be A Wiccan" trash and read Anything We Love Can Be Saved. Walker's connection to the land, to Mother Earth, and to Spirit is as Pagan as it gets. This book is profoundly beautiful, profoundly Pagan. She understands that we belong to this wonderful planet, and that real worship of deity is not possible unless we're free, including free to explore and revel in our sexuality. She understands our connectedness to other animals, the nonhuman ones, and espouses their humane treatment as well.

Hope Doesn't Spring Eternal Without Human Compassion, Desires, and Activism .......2006-10-31

Alice Walker writes ideas I don't already know, and she gives me new ways of interpreting people. She is worth considering, especially when you think you disagree with her. It is better to engage her in thoughtful debate than to not listen to what she has to say. Ms. Walker did not title this book "Anything I Love Can Be Saved." Importantly, she chose "Anything WE Love Can Be Saved." The book discusses pursuits she has shared with others.

"Now I know that . . .activism is often my muse . . . All we own, at least for the short time we have it, is our life . . . Whenever I experience evil, and it is not, unfortunately, uncommon to experience it in these times, my deepest feeling is disappointment. I have learned to accept the fact that we risk disappointment, disillusionment, even despair, every time we act. Every time we decide to believe the world can be better. Every time we decide to trust others to be as noble as we think they are. And that there might be years during which our grief is equal to, or even greater than, our hope. The alternative, however, not to act, and therefore to miss experiencing other people at their best, reaching toward their fullness, has never appealed to me." pp. xxiv-xxv.

I've spent a good deal of time researching concepts of love. Many people are familiar with Paul's description of love's attributes from 1 Corinthians 13. Alice Walker highlights the next chapter's oppression of women in the verses of 1 Corinthians 14:33-35. "For God is not a God of disorder but of peace. As in all the congregations of the saints, women should remain silent in the churches. They are not allowed to speak, but must be in submission, as the Law says. If they want to inquire about something, they should ask their own husbands at home; for it is disgraceful for a woman to speak in the church." I have to agree with Ms. Walker's assertion that the Bible was written by men. And I doubt any intelligent "god" would seek any "peace" that silences women or dictates they become intellectual subordinates to their husbands. As I have grown older, I've found more community and guidance from the voices of women.

"If the women of the world were comfortable, this would be a comfortable world."

To understand what the title of this book might be saying, a person must interpret how Alice Walker is using the word "saved." "Saved" is a word I have trouble with because I grew up in a religious community where a person could only be "saved" by choosing one being and one way. Seeking additional voices or additional community was "fallen" or "depraved." Alice Walker does not appear to be primarily be using the word "saved" in the commonly connotated evangelical "conversion to more enlightened path" sense. She is also not primarily using the word "saved" to promote "possession or acquisition of" another human being.

Ms. Walker emphasizes "saved" in the sense that any person, idea, or object of good character can be remembered, preserved, nourished, grown, and sheltered by love. She says "love and justice and truth are the only monuments that generate everwidening circles of energy and life . . . though trashed and trampled, generation after generation."

She discusses principles of preserving and sharing past loves in relation to recounting how written word efforts and community acknowledgement have honored Zora Neale Hurston, a woman who herself wrote in order to honor and preserve the often concealed, but discretely passed down, African American culture that survived hundreds of years of slavery and discriminatory religious & cultural practices.

Zora also wrote to preserve the memory of specific loves from her personal history. In Zora's work, Alice found a character named Shug, Alice's "outside" grandmother, her grandfather's lover, whose descendant Alice was named after. And if you've read or watched The Color Purple, you are familiar with Shug. There are real people behind most great literary characters.

Alice believes in preserving and sharing the good qualities of those who were unjustly dishonored and have passed from view. Her essay "Anything We Love Can Be Saved" was an address she gave at the the First Annual Zora Neale Hurston Festival in 1990, a festival bringing attention to and honoring the writings of Zora Neal Hurston. Injustice is not overcome through silence. As the subtitle of this book "A Writer's Activism" emphasizes, love is active, notorious, and publicized. The act of love may start "First in their own hearts," but it must be communicated to and shared with "the hearts of others. They have only to make their love inseparable from their belief. And both inseparable from hard work . . . Paying homage to her, memorializing her light, her struggle . . . brought us peace."

Sadness, not Depression.......2006-10-30

I am a lonely and sad person regularly. I would not describe myself as depressed, because depression too often has a meaning that the person is down due to misunderstanding. My sadness is borne out of knowing that worthwhile ideas, methods, and interactions exist, and knowing I am no longer able to participate with them. (Which ironically is an underestimated and underdiagnosed cause of real, clinical depression.)

When I get too sad, I pick up a book like this one by an author who has an insightful & challenging voice. When I feel an absence of someone challenging me with new & good ideas, I pretend that instead of just reading Ms. Walker's books - I pretend she is in the room with me discussing her radical ideas and intent on keeping me company with her arousing ideals. I imagine she appreciates attentive feedback, and a willingness to thoroughly consider all her ideas, even when she is angry.

And when I pause between ideas, I dream of a world that doesn't exist. I dream that most people would choose to act in ways similar to Ms. Walker. I allow myself to fantasize that most parents might choose to be less hypocritical and would agree to say for the sake of their daughters, "all I can promise her is not to lie" even if it "is painful to her, I believe nonetheless it is better than a lie. Surely better than the lies I was told - 'for my own good' - only to sniff them out eventually and become entangled in them."

Then I get a peaceful, easy feeling and like a mad one, I choose to live as if "love is best expressed through truth," "Because to me, it is precisely our personal memories of joy and delight in each other and our present passions and loves that sustain us." p. 66

And like Ms. Walker, I stubbornly refuse to forget or to pretend those memories never occured. It is a lonely refusal. It may be an unwise refusal. But it is a less unhealthy refusal for me than hypocrisy. It is not a raging refusal (as Ms. Walker indicates it is in her at times). And it is not a depressed refusal. It is a clear, conscious, chosen & sad refusal. And in that existence, I thank Ms. Walker for her ideas, her stubborn voice, her words against likely failures, and in my imaginary world - her companionship.

I love this book........2006-05-02

I want to be Alice Walker when I grow up, too bad that job has already been taken.

Thought Provoking.......2000-11-28

This is a very interesting book. One of the things that I enjoy most about Walker's writing is her ability to convey her perspective of the world. I esspecially liked the first two essay's, and the essay on her cat. I don't agree with absolutly all of Walker's points (Though I do agree with most of them), but this does nothing to undermine the power of the book. The book is sub-titled "A Writer's Activism" and it left me thinking about the place of activism in my own life. I would certainly recommend this book to anyone with an open mind, especially when read in conjunction with Walker's book of short stories, "You Can't Keep a Good Woman Down".

Anything We Love Can Be Saved - A Writer's Activism

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Anything We Love Can Be Saved - A Writer's Activism
Alice Walker
Manufacturer: Random House
ProductGroup: Book
Binding: Hardcover

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Anything We Love Can Be Saved: A Writer's Activism
Alice, 1944- Walker
Manufacturer: see notes for publisher info
ProductGroup: Book
Binding: Hardcover
ASIN: B000NP12TA

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Anything We Love Can be Saved: A Writer's Activism
Alice Walker
Manufacturer: Random House
ProductGroup: Book
Binding: Paperback

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Anything We Love Can Be Saved

Manufacturer: PHOENIX (ORIO)
ProductGroup: Book
Binding: Paperback
ASIN: B000GSI9IG

Anything We Love Can Be Saved : A Writer's

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Anything We Love Can Be Saved : A Writer's
Alice Walker
Manufacturer: Ballantine Books
ProductGroup: Book
Binding: Paperback

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