Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling (Methods and Principles in Medicinal Chemistry, Volume 15)

Book Description

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes.
Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given.
This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

Lipid Bilayers: Structure and Interactions (Biological and Medical Physics, Biomedical Engineering)

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Lipid Bilayers: Structure and Interactions (Biological and Medical Physics, Biomedical Engineering)
J. Katsaras , and T. Gutberlet
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

Biophysics | Biological Sciences | Science | Subjects | Books

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ASIN: 3540675558

Book Description

A general review of lipid bilayer structure and dynamics is given, including such current topics as the hydration of lipid bilayers, the superstructural behaviour of bilayers at different states of hydration and external conditions, the role and behaviour of lipid bilayers on fusion and rupture and the interaction of lipid bilayers with small organic molecules and additives and of protein lipid bilayer interactions. In addition, recent research on lipid interaction with proteins and other molecules in monolayers is reviewed, and the use of highly aligned samples under biologically relevant conditions and the benefits derived from such preparations are addressed. Finally, the latest approach in simulation of impurities within a lipid bilayer is introduced. This book will be a comprehensive review of the current state of biologically relevant model membrane systems which will become an indispensible reference for the "working biophysicist".

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Lipid Bilayers : Structure and Interactions (Biological and Medical Physics, Biomedical Engineering)
J. Katsaras
Manufacturer: NY
ProductGroup: Book
Binding: Hardcover
ASIN: B000MU887U

Membrane proteins and their interactions with lipids (Membrane proteins)

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Membrane proteins and their interactions with lipids (Membrane proteins)

Manufacturer: M. Dekker
ProductGroup: Book
Binding: Unknown Binding

Physiology | Basic Science | Medicine | Subjects | Books

Book Description

This text offers a selection of papers on singularity theory presented at the Sixth Workshop on Real and Complex Singularities held at ICMC-USP, Brazil. It should help students and specialists to understand results that illustrate the connections between singularity theory and related fields. The authors discuss irreducible plane curve singularities, openness and multitransversality, the distribution Afs and the real asymptotic spectrum, deformations of boundary singularities and non-crystallographic coxeter groups, transversal Whitney topology and singularities of Haefliger foliations, the topology of hypersurface singularities, polar multiplicities and equisingularity of map germs from C3 to C4, and topological invariants of stable maps from a surface to the plane from a global viewpoint.

Real and Complex Singularities (Pitman Research Notes in Mathematics Series)

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Real and Complex Singularities (Pitman Research Notes in Mathematics Series)
W. L. Marar
Manufacturer: Chapman & Hall/CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 0582277809

Book Description

Much progress has been made recently in a number of areas by the application of new geometrical methods arising from advances in singularity theory. This collection of invited papers presented at the 3rd International Workshop on Real and Complex Singularities, held in August 1994 at ICMSC-USP (Sao Carlos), documents the geometric study of singularities and its applications.

Real and Complex Singularities (Research Notes in Mathematics Series)

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Real and Complex Singularities (Research Notes in Mathematics Series)

Manufacturer: Chapman & Hall/CRC
ProductGroup: Book
Binding: Paperback

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Book Description

The boundaries of singularity theory are broad and vague, connecting the most important applications of mathematics and science with more abstract areas. Optics, robotics, computer vision, Hamiltonian mechanics, bifurcation theory and differential equations are among the variety of topics that benefit from developments in the theory. With singularity theory encompassing more and more applications, Real and Complex Singularities provides insight into the future of this expanding field. Comprising refereed contributions to the Fifth Workshop on Real and Complex Singularities, this volume addresses three important areas related to the broad subject of singularities. The first section deals with questions within singularity theory itself, representing the topics currently being investigated. The second explores applications of singularity theory to differential geometry, robotics, and computer vision. The final section consists of applications to bifurcation theory and dynamical systems. With over two-hundred tables that provide quick access to data, this volume is a complete overview of the most current topics and applications of singularity theory. Real and Complex Singularities creates the opportunity for you to stay up-to-date with recent advances and discover promising directions for future research in the field.

Real and Complex Singularities (Trends in Mathematics)

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Real and Complex Singularities (Trends in Mathematics)

Manufacturer: Birkhaueser
ProductGroup: Book
Binding: Hardcover

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Product Description

The São Carlos Workshop on Real and Complex Singularities is the longest running workshop in singularities. It is held every two years and is a key international event for people working in the field. This volume contains papers presented at the eighth workshop, held at the IML, Marseille, July 19-23, 2004.

The workshop offers the opportunity to establish the state of the art and to present new trends, new ideas and new results in all of the branches of singularities - reflected by the contributions in this book: equisingularity of sets and mappings, geometry of singular complex analytic sets, singularities of mappings, characteristic classes, classification of singularities, interaction of singularity theory with some of the new ideas in algebraic geometry imported from theoretical physics, applications of singularity theory to geometry of surfaces in low dimensional euclidean spaces, to differential equations and to bifurcation theory.

Real and Complex Singularities: Proceedings of the Australian-Japanese Workshop, University of Sydney, Australia, 5-8 September 2005

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Real and Complex Singularities: Proceedings of the Australian-Japanese Workshop, University of Sydney, Australia, 5-8 September 2005

Manufacturer: World Scientific Publishing Company
ProductGroup: Book
Binding: Hardcover

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Real And Complex Singularities: Proceedings Of The Seventh International Workshop On Real And Complex Singluarlities, July 29-august 2, 2002, ICMC-USP, Sao Carlos, Brazil (Contemporary Mathematics)

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Real And Complex Singularities: Proceedings Of The Seventh International Workshop On Real And Complex Singluarlities, July 29-august 2, 2002, ICMC-USP, Sao Carlos, Brazil (Contemporary Mathematics)

Manufacturer: American Mathematical Society
ProductGroup: Book
Binding: Paperback

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Real and Complex Singularities Oslo 1976: Proceedings of the Nordic Summer School/Navf Symposium in Mathematics, Oslo, August 5-25, 1976

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Real and Complex Singularities Oslo 1976: Proceedings of the Nordic Summer School/Navf Symposium in Mathematics, Oslo, August 5-25, 1976

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Real & Complex Singularities Notes 333
MARAR
Manufacturer: John Wiley & Sons Inc
ProductGroup: Book
Binding: Hardcover

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Real and Complex Singularities.

ProductGroup: Book
Binding: Paperback
ASIN: B000IBI35K

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Real and Complex Singularities.
W.L. Marar
Manufacturer: Publisher Unknown
ProductGroup: Book
Binding: Paperback
ASIN: B000UFPC30

Book Description

The Assassination Bureau kills people for money, but it also has a social conscience. The leader of the group justifies each killing--until the day he accepts a contract to kill himself.

Customer Reviews:

Outstanding!!.......2004-03-24

This book is one of the most interesting and mind grabbing that I have ever read! It brought me back from a reading hitus that I had suffered for over a year; it reminded me of how much I love books!

The story is about Dragomiloff creating his bureau and justifying the assasinations they carry out. One man challenges him and proves Dragomiloff that his bureau's work is wrong. This causes Dragomiloff to send his bureau after himself, for his assassination.

This book is truly one of his best ever and should be read by everyone, espically the people who think that London writes only about the artic. This is an intreaguing read full of twists and turns. I would reccomend it to anyone.

TERRIBLE.......2003-11-05

Apparently, this unfinished novel was found in the deceased Jack London's trunk. Trying to cash in on JL's name, Robert L. Fish, "finishes" the book. Well, there's a reason London gave up on it and threw it in the trunk in the first place... It's terrible.

Billed as an assassination bureau with a conscience, its chief, Ivan Dragomiloff decides whether the assassinations are "justified." Eventually, someone submits an anonymous name for termination, which Dragomiloff dutifully accepts. Well, he's the target. London quickly paints himself into a corner and the novel deteriorates into idiocy.

At a mere 178 pages it was hard to NOT finish even if you realize about half way through you're wasting your time. Some novels are better left unread. This is one of them.

great concept, but.......2003-04-25

the plot in this book is very interesting. the bureau in question is adminitrated towards killing people who "deserves" it. their clients have to convince the leader that the person deserves to be killed. a man shows up and convinces the leader that it is HIM (the leader) that deserves to be killed, and this person agrees at last. interesting concept. but after a while the plot gets less interesting. L doesn't seem to manage his own idea, and things end up just sort of happening. not his best.

A very good read.......2002-04-12

I read this book after seeing the movie because I'm an Oliver Reed fan, like so many books, the movie version is so different. But I still enjoyed reading this book, written a long time ago (for me) some parts were quite difficult to read in this drama about a group of assassins who are payed to kill their leader, the film continues in a chase to find the member of the bureau who would kill Dragomiloff the leader, or to see if he successfully managed to eliminate all of them. Seeing the film first, I do prefer the film but still find this a very enjoyable read.

Assassination Bureau.......2000-03-23

London supposedly "wrote himself into a corner" in the plot of this story, or else he hadn't the time to finish it, but the resolution by Fish is not only an entertaining conclusion (despite a certain abrupt removal of a key character), but is so similar to London's writing style and his familiarities so that the author transfer is indeterminable. The best part of the book as a whole, as all Londonites will agree, is the simple philisophical dialogue exchanged between characters. For those who are seeking a die-hard, man vs. nature conflict, you still won't be disappointed with the primitiveness of the characters (philisophical, mad, and fanatic) and their interaction with a civilized world that doesn't quite match the truths that they hold to be dear. An excellent read.

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The Assassination Bureau, Ltd

Manufacturer: McGraw-Hill
ProductGroup: Book
Binding: Hardcover
ASIN: B000EIJV1W

Product Description

Completed from his notes by Robert L. Fish. This crime novel was only two-thirds complete when Jack London died.

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The Assassination Bureau Ltd.
Jack London & Robert L. Fish
Manufacturer: Berkeley Medalion Books
ProductGroup: Book
Binding: Mass Market Paperback
ASIN: B000RWIKAS

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The Assassination Bureau Ltd.

Manufacturer: Berkley Books
ProductGroup: Book
Binding: Paperback
ASIN: 0425017192

Product Description

Imagine yourself the mastermind of a syndicate that commits murders for hire - but only after you, the burear chief, have decided that killing is morally "justified". Then imagine a client offering to pay you any price whatsoever, provided you agree to a killing before he tells you who the victim is to be. And THEN imagine how you would feel when your client announces that the proposed murderee is YOU! Made into a motion picture starring: Oliver Reed - Diana Rigg - Telly Savalas

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The Assassination Bureau Ltd.
Jack and Fish, Robert L. London
Manufacturer: Berkley Medallion
ProductGroup: Book
Binding: Mass Market Paperback
ASIN: B000H8E8US

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The Assassination Bureau, Ltd
Jack London
Manufacturer: Penguin Classics
ProductGroup: Book
Binding: Paperback
ASIN: B000OJ1P2O

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The Assassination Bureau, Ltd.
Jack; Fish, Robert L. London
Manufacturer: Penguin Books
ProductGroup: Book
Binding: Paperback
ASIN: B000NXTS2K

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The Assassination Bureau, Ltd.
Jack London & Robert L. Fish
Manufacturer: Berkley Medallion Books
ProductGroup: Book
Binding: Paperback
ASIN: B000Q5AT50

Asesinatos, S.L./ The Assassination Bureau Ltd.

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Asesinatos, S.L./ The Assassination Bureau Ltd.
Jack London
Manufacturer: Alianza Editorial Sa
ProductGroup: Book
Binding: Hardcover

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The Assassination Bureau Ltd
Jack London
Manufacturer: Andre Deutsch
ProductGroup: Book
Binding: Unknown Binding
ASIN: B0000CMDT8

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