Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data

Book Description

A fully revised version of the successful First Edition, this one-stop reference book enables all geneticists to improve the efficiency of their research.

The study of human genetics is moving into a challenging new era. New technologies and data resources such as the HapMap are enabling genome-wide studies, which could potentially identify most common genetic determinants of human health, disease and drug response. With these tremendous new data resources at hand, more than ever care is required in their use. Faced with the sheer volume of genetics and genomic data, bioinformatics is essential to avoid drowning true signal in noise. Considering these challenges, Bioinformatics for Geneticists, Second Edition works at multiple levels: firstly, for the occasional user who simply wants to extract or analyse specific data; secondly, at the level of the advanced user providing explanations of how and why a tool works and how it can be used to greatest effect. Finally experts from fields allied to genetics give insight into the best genomics tools and data to enhance a genetic experiment.

Hallmark Features of the Second Edition:

Illustrates the value of bioinformatics as a constantly evolving avenue into novel approaches to study genetics
The only book specifically addressing the bioinformatics needs of geneticists
More than 500f chapters are completely new contributions
Dramatically revised content in core areas of gene and genomic characterisation, pathway analysis, SNP functional analysis and statistical genetics
Focused on freely available tools and web-based approaches to bioinformatics analysis, suitable for novices and experienced researchers alike

Praise for the First Edition:

”…a very valuable and important resource for bringing bioinformatics into the work practice of geneticists… we strongly recommend this book…” CLINICAL CHEMISTRY, 2004

”…a useful addition to the library of a seasoned scientist… a useful resource in itself, cataloguing the ‘how’ and ‘why’…” BRIEFINGS IN BIOINFORMATICS, June 2004

Bioinformatics for Geneticists, Second Edition describes the key bioinformatics and genetic analysis processes that are needed to identify human genetic determinants. The book is based upon the combined practical experience of domain experts from academic and industrial research environments and is of interest to a broad audience, including students, researchers and clinicians working in the human genetics domain.

Customer Reviews:

A Timely Primer for Researchers about the Analysis of Genetic Data.......2007-08-23

This book is a welcomed addition to the literature of bioinformatics. It helps one become familiar with how to find and use genetic data. This is a dauting task for most investigators who must navigate through the sea of genetic data now being produced. Analyzing genetic data is not an easy task but this book helps one identify resources and map a course.

Bioinformatics for Geneticists (Hierarchical Exotoxicology Mini Series)

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Bioinformatics for Geneticists (Hierarchical Exotoxicology Mini Series)

Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Hardcover

Bioinformatics | Biological Sciences | Science | Subjects | Books

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Book Description

This timely book illustrates the value of bioinformatics, not simply as a set of tools but rather as a science increasingly essential to navigate and manage the host of information generated by genomics and the availability of completely sequenced genomes. Bioinformatics can be used at all stages of genetics research: to improve study design, to assist in candidate gene identification, to aid data interpretation and management and to shed light on the molecular pathology of disease-causing mutations. Written specifically for geneticists, this book explains the relevance of bioinformatics showing how it may be used to enhance genetic data mining and markedly improve genetic analysis.

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Bioinformatics for Geneticists describes a step by step approach to key bioinformatics and genetic analysis procedures, based upon practical experience gained after many years of direct bioinformatics support for laboratory geneticists. It features detailed case studies of problems and analytical approaches that are specific to the needs of the genetics researcher. The book contains reviews of bioinformatics tools and genetic databases. Each chapter is written to capture the principles of analysis regardless of the tool used, thereby ensuring that the book stays relevant as new data and tools become available. As the first book specifically addressing the informatics requirements of geneticists, Bioinformatics for Geneticists is essential reading for all those engaged in genetic research and should prove indispensable for both the planning and analysis of such studies. The book provides in-depth coverage of the underlying principles of both genetic and bioinformatic analysis which should make this book suitable for all students of genetics or bioinformatics. The book takes a web-based approach to bioinformatics, suitable for bot h internet novices and more experienced web users. The focus is on public software tools and databases freely available to all. The editors and authors bring a broad range of experience from academic and industrial genetics research environments. The book is accessible to individuals outside the immediate field of molecular genetics, e.g. statisticians, epidemiologists and physicians who wish to improve their knowledge of bioinformatics and genetics. This is currently the only book specifically aimed at the bioinformatics needs and priorities of genetics researchers.

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Bioinformatics for Geneticists
Michael Barnes
Manufacturer: NY
ProductGroup: Book
Binding: Paperback

Bioinformatics | Biological Sciences | Science | Subjects | Books
ASIN: B000N7EO8E

Book Description

This comprehensive volume brings you a resource covering the very latest technological developments for polyolefins. You'll benefit from the expertise of noted authorities and for the first time will find a comprehensive description of the structuring of molten polyolefins in fiber, film and molding processes with correlations between structural order such as crystalline unit cell, polymorphic effect and orientation, and processing parameters.

Written by leading experts, this book provides a truly authoritative resource for polyolefins. The book treats the history, commercialization, characterization, and crystallography of various commercial polyolefins and polystyrenes and describes development of structure during fabrication of these polymers into various shapes.

Book Description

This digital document is an article from Polymer Engineering and Science, published by Society of Plastics Engineers, Inc. on June 1, 1997. The length of the article is 2855 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: In this work a preliminary study on the viscoelastic behavior of polyolefinic foam sheets with different chemical (polyethylene and polypropylene) and cellular structure by means of Dynamical Mechanical Analysis (DMA), in the low frequency and low compression ranges, is presented. Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM) are also used to determine the morphological parameters of the samples. A connection between the morphological parameters (apparent degree of crystallinity, type of cellular structure, homogeneity, cell size and shape, cell-wall thickness) and the viscoelastic behavior, a basic key for the development of mechanical and insulating applications, has been established.

Citation Details
Title: Dynamic mechanical properties of polyolefin foams studied by DMA techniques. (dynamical mechanical analysis)(International Forum on Polymers - 1996)
Author: M.A. Rodriguez-Perez
Publication: Polymer Engineering and Science (Refereed)
Date: June 1, 1997
Publisher: Society of Plastics Engineers, Inc.
Volume: v37 Issue: n6 Page: p959(7)

Distributed by Thomson Gale

Structure and properties of in situ compatibilized polystyrene/polyolefin elastomer blends.: An article from: Polymer Engineering and Science

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Structure and properties of in situ compatibilized polystyrene/polyolefin elastomer blends.: An article from: Polymer Engineering and Science
Zhenghong Guo , Lifang Tong , Zhongbin Xu , and Zhengping Fang
Manufacturer: Thomson Gale
ProductGroup: Book
Binding: Digital

Book Description

This digital document is an article from Polymer Engineering and Science, published by Thomson Gale on June 1, 2007. The length of the article is 4811 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: To increase the compatibility of polystyrene (PS) and polyolefin elastomer (POE) blends, a Lewis acid catalyst, aluminum chloride (Al[Cl.sub.3]), was adopted to initiate the Friedel-Crafts alkylation reaction for the formation of PS-graft-POE copolymer. Dynamic mechanical analysis indicated that PS/POE and PS/POE/Al[Cl.sub.3] blends are partially miscible, and the formation of PS-graft-POE copolymer increased the compatibility between PS and POE. Scanning electron microscope and transmission electron microscope results showed that the domain size of the blends decreased dramatically and the size distribution became more uniform with the addition of Al[Cl.sub.3]. Such in situ compatibilization also induced hindrance to the macromolecular chain movement, as reflected by the results of the dynamic rheological analysis. The dynamic rheological behaviors of PS/POE and PS/POE/Al[Cl.sub.3] blends under different temperature showed that in situ compatibilization weakened the effects of thermooxidation on PS/POE blends. Moreover, in situ compatibilization decreased the activation energy of viscous flow and reduced the influence of temperature on PS/POE blends. POLYM. ENG. SCI., 47:951-959, 2007. [c] 2007 Society of Plastics Engineers

Citation Details
Title: Structure and properties of in situ compatibilized polystyrene/polyolefin elastomer blends.
Author: Zhenghong Guo
Publication: Polymer Engineering and Science (Magazine/Journal)
Date: June 1, 2007
Publisher: Thomson Gale
Volume: 47 Issue: 6 Page: 951(9)

Distributed by Thomson Gale

Structure/property relationships in polyolefins made by constrained geometry catalyst technology.: An article from: Plastics Engineering

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Structure/property relationships in polyolefins made by constrained geometry catalyst technology.: An article from: Plastics Engineering
P.S. Chum , C.I. Kao , and G.W. Knight
Manufacturer: Society of Plastics Engineers, Inc.
ProductGroup: Book
Binding: Digital

Book Description

This digital document is an article from Plastics Engineering, published by Society of Plastics Engineers, Inc. on June 1, 1995. The length of the article is 1679 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Structure/property relationships in polyolefins made by constrained geometry catalyst technology.
Author: P.S. Chum
Publication: Plastics Engineering (Refereed)
Date: June 1, 1995
Publisher: Society of Plastics Engineers, Inc.
Volume: v51 Issue: n6 Page: p21(3)

Distributed by Thomson Gale

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Polyolefins: Structure and Properties.
Herman V. Boenig
Manufacturer: see notes for publisher info
ProductGroup: Book
Binding: Unknown Binding
ASIN: B0000CN5L5

Book Description

Fuzzy logic provides a unique method of approximate reasoning in an imperfect world. This text is a bridge to the principles of fuzzy logic through an application-focused approach to selected topics in Engineering and Management. The many examples point to the richer solutions obtained through fuzzy logic and to the possibilities of much wider applications.
There are relatively few texts available at present in fuzzy logic applications. The style and content of this text is complementary to those already available. New areas of application are presented in a graded approach in which the underlying concepts are first described. The text is broadly divided into two parts which treat Processes and Materials and also System Applications.
The level enables a selection of the text to be made for the substance of a senior undergraduate level course. There is also sufficient volume and quality for the basis of a postgraduate course. A more restricted and judicious selection can provide the material for a professional short course.

An Introduction to Fuzzy Logic Applications in Intelligent Systems (The International Series in Engineering and Computer Science)

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An Introduction to Fuzzy Logic Applications in Intelligent Systems (The International Series in Engineering and Computer Science)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

General | Computers & Internet | Subjects | Books

General | Software | Computers & Internet | Subjects | Books

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Book Description

An Introduction to Fuzzy Logic Applications in Intelligent Systems consists of a collection of chapters written by leading experts in the field of fuzzy sets. Each chapter addresses an area where fuzzy sets have been applied to situations broadly related to intelligent systems.
The volume provides an introduction to and an overview of recent applications of fuzzy sets to various areas of intelligent systems. Its purpose is to provide information and easy access for people new to the field. The book also serves as an excellent reference for researchers in the field and those working in the specifics of systems development. People in computer science, especially those in artificial intelligence, knowledge-based systems, and intelligent systems will find this to be a valuable sourcebook. Engineers, particularly control engineers, will also have a strong interest in this book.
Finally, the book will be of interest to researchers working in decision support systems, operations research, decision theory, management science and applied mathematics. An Introduction to Fuzzy Logic Applications in Intelligent Systems may also be used as an introductory text and, as such, it is tutorial in nature.

Introduction to Fuzzy Sets, Fuzzy Logic, and Fuzzy Control Systems

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Introduction to Fuzzy Sets, Fuzzy Logic, and Fuzzy Control Systems
Guanrong Chen , and Trung Tat Pham
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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Similar Items:

Numerical Analysis: Mathematics of Scientific Computing

ASIN: 0849316588

Book Description

In the early 1970s, fuzzy systems and fuzzy control theories added a new dimension to control systems engineering. From its beginnings as mostly heuristic and somewhat ad hoc, more recent and rigorous approaches to fuzzy control theory have helped make it an integral part of modern control theory and produced many exciting results. Yesterday's "art" of building a working fuzzy controller has turned into today's "science" of systematic design. To keep pace with and further advance the rapidly developing field of applied control technologies, engineers, both present and future, need some systematic training in the analytic theory and rigorous design of fuzzy control systems. Introduction to Fuzzy Sets, Fuzzy Logic, and Fuzzy Control Systems provides that training by introducing a rigorous and complete fundamental theory of fuzzy sets and fuzzy logic, and then building a practical theory for automatic control of uncertain and ill-modeled systems encountered in many engineering applications. The authors proceed through basic fuzzy mathematics and fuzzy systems theory and conclude with an exploration of some industrial application examples. Almost entirely self-contained, Introduction to Fuzzy Sets, Fuzzy Logic, and Fuzzy Control Systems establishes a strong foundation for designing and analyzing fuzzy control systems under uncertain and irregular conditions. Mastering its contents gives students a clear understanding of fuzzy control systems theory that prepares them for deeper and broader studies and for many practical challenges faced in modern industry.

Customer Reviews:

A Spicy Brew.......2005-06-23

Some give the sheaf to Charles Brockden Brown but I far prefer the mellow stylings of Washington Irving, the sage of Tarrytown. When I was a boy I was introduced to this splendid body of work by one of my grade school teachers, a collateral relative of Washington Irving, a man who hailed from upstate New York and who carried in his bloodlines some of the authentically spooky platelets of colonial America. During the Napoleonic period the US was not necessarily a pretty place to live in, and Irving's famous story THE HEADLESS HORSEMAN shows us some of the dark underbelly of American life. You really weren't safe out of your own good, and at night travel was even more dangerous. Plus, as anyone who's read the story of Ichabod Crane knows, people were just as prone to jeer and mock the funny-looking as they are today. The story is heartbreaking on two levels, the naturalistic and the symbolic. We all know someone like Ichabod Crane, and many of us find ourselves mirrored in his lonely gaze and terrifying gallop through Hessian country. Irving, like Hawthorne, wrote out many of his tales swearing they were as "his grandfather told him," and thus they are set in a period before his own, a misty place of the past that he knew how to make terrifyingly real and relevant.

My teacher also reminded us that Washington Irving was a very cultured man who believed, like Johnny Appleseed, in planting America with the fruits of other, older lands, so that among his stories you will find some from Europe, re-told to make them apropos and socially relevant for the rawness of a new world.

For horror and fright Washington Irving has few rivals, and the bonus is an added richness as of old apples carpeting a winter meadow, and thus this book, edited by a Twain expert, smells like spicy cider on New Years Eve; lots of good cheer along with your ghosts.

Mystery and Romance in Rural Settings.......2004-01-19

(This review refers to the PUFFIN Anthology.)

This Puffin anthology presents five of Irving's short stories--tales of fantasy, legend and unrequited love--all set in rural New York and Europe, orignally published in 1820. His literary genius
was quickly evident; the elegant style contributed to his
accolade as "the father of American literature." Despite minimal dialogue the author captivates serious readers with his lush descriptions of scenery, bizarre twists of fate or

imagination, often interspersed with touches of wry humor.

Examining the follies of the human mind, as well as the foibles of the human heart, Irving has chosen the following subjects:
romance, ghosts, ambition, naivety, and pedantry. RIP VAN WINKLE and THE LEGEND OF SLEEPY HOLLOW are set in Dutch New York; THE SPECTRE BRIDEGROOM in the forests of Germany. THE PRIDE OF THE VILLAGE takes place in rural, Hardyesque England, while MOUNTJOY returns readers to Yankee New York state. This anthology provides delectable reading for an armchair by the hearth--especially in chilly, hobgoblin weather--by a premier raconteur
and US diplomat.

Proof of the talent of an important American author.......1998-04-11

This wonderful collection proves once and for all that there is more to Irving than "Rip Van Winkle" and "The Legend of Sleepy Hollow". The stories contained within this volume are wonderfully told and sparkle with imagination. The pieces from "The Alahambra" were the most impressive.

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The Complete Tales of Washington Irving
Washington / Neider, Charles [ed, intro] Irving
Manufacturer: Doubleday
ProductGroup: Book
Binding: Hardcover
ASIN: B000JOFD18

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Complete Tales
Washington Irving
Manufacturer: International Collectors Library
ProductGroup: Book
Binding: Hardcover

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The Complete Tales of Washington Irving
Washington Irving
Manufacturer: Book Club
ProductGroup: Book
Binding: Hardcover

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The Complete Tales of Washington Irving
Charles Neider
Manufacturer: Doubleday and Company, Inc
ProductGroup: Book
Binding: Hardcover
ASIN: B000PBO0J6

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The Complete Tales of Washington Irving
Washington Irving
Manufacturer: International Collectors Library
ProductGroup: Book
Binding: Hardcover

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The Complete Tales of Washington Irving
Washington: Neider, Charles [editor] Irving
Manufacturer: International Collectors Library
ProductGroup: Book
Binding: Hardcover
ASIN: B000LBWIIK

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The Complete Tales of Washington Irving
Washington (edited By Neider, Charles) Irving
Manufacturer: Doubleday & Company
ProductGroup: Book
Binding: Hardcover
ASIN: B000K092PO

Tales of a Traveller/by Geoffrey Crayon, Gent (Complete Works of Washington Irving, Vol 10)

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Tales of a Traveller/by Geoffrey Crayon, Gent (Complete Works of Washington Irving, Vol 10)
Washington Irving
Manufacturer: Twayne Pub
ProductGroup: Book
Binding: Hardcover

United States | Short Stories | Literature & Fiction | Subjects | Books

British | Short Stories | Literature & Fiction | Subjects | Books

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The Complete Tales of Washington Irving
Charles) Irving Washington (edited By Neider
Manufacturer: Doubleday & Company
ProductGroup: Book
Binding: Hardcover
ASIN: B000U35JQW

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