The Clock of Ages: Why We Age, How We Age, Winding Back the Clock
Average customer rating: 4 out of 5 stars
  • A very interesting book
  • A journey into the mechanics of aging
  • Good Summary But Missing One Discussion
  • "The Clock of Ages" Makes for Good Time
The Clock of Ages: Why We Age, How We Age, Winding Back the Clock
John J. Medina
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0521462444

Book Description

A few gray hairs and a couple of wrinkles are often the first visible signs of aging on our bodies. For most of us, however, aging remains largely a mystery. We can only wonder why we have to age and what casualty of age hovers nearby. Written in everyday language, The Clock of Ages takes us on a tour of the aging human body--all from a research scientist's point of view. From the deliberate creation of organisms that live three times their natural span to the isolation of genes that may allow humans to do the same, The Clock of Ages also examines the latest discoveries in geriatric genetics. Sprinkled throughout the pages are descriptions of the aging of many historical figures, such as Florence Nightingale, Jane Austen, Billy the Kid, Napoleon, and Casanova. These stories underscore the common bond of senescence that unites us all. The Clock of Ages tells us why.

Customer Reviews:

4 out of 5 stars A very interesting book.......2005-12-30

I really enjoyed reading this didactic book, but I was a little dissapointed at the end.... I thought he was going to talk more about diet and life style, but he didn't. Maybe in a future edition, who knows. Anyway, it's a very good book, you should read it.

4 out of 5 stars A journey into the mechanics of aging.......2000-03-25

Reading this book reminded me of a ride I once took at Disneyland where everything gets bigger and bigger so that you feel as if you are being reduced to microscopic size. You then travel into the human body, then a cell and then see the molecules that make them up. Medina starts with the human face of ageing - the final moments in the life of his aged mother - and then takes us on a journey from the outward signs of ageing to the molecular machinery which makes what he calls the "clock of ages" tick.

Despite our anxieties of "getting old" ageing starts long before we see wrinkles or grey hair. In fact, ageing is a complex developmental process which starts at conception. Despite taking such a biological view Medina never loses sight of the individual. The effects of ageing on the lives of many famous people are interspersed through the book with amazing facts about the body: Florence Nightingale was a hypochondriac who spent most of her adult life in bed and each of us contains about 60,000 miles of blood vessels!

Some in the field claim that our exploding knowledge of the mechanics of cellular renewal and DNA will see us living twice or three times our current life spans in approximately 30 years.

4 out of 5 stars Good Summary But Missing One Discussion.......1999-04-08

Medina's work is an excellent, readable summary of what's currently known about aging. As it turns out, there are more questions than answers.

However, in amongst all the discussion of immortality I wish he had devoted a chapter to the wisdom of such a quest. He mentions in passing the ants and bees who each perform a distinct function and, separated from their hive or nest, expire rather quickly. Medina repeats the oft-quoted maxim that they are more like a single organism with independently-functioning cells than like distinct individuals.

I wish he had extended this analogy to mankind, and showed how immortality would be to the detriment of long-term species survival in a changing environment. "Descent with modifications" relies on continual refreshing of the genetic material. Lewis Thomas and Stephen Jay Gould (and even Richard Dawkins) have put forward the idea that the individual is not the prime target of evolution, and I think this paradigm shift helps explain the causes of, and need for, aging.

4 out of 5 stars "The Clock of Ages" Makes for Good Time.......1997-02-02

"The Clock of Ages" by John J. Medina is subtitled 'Why We Age, How We Age, Winding Back the Clock.' Dr. Medina more adequately addressed the 'Why' and the 'How' of aging than the 'Winding Back the Clock.' As might be expected from a molecular biologist, Medina is at his most technical and most detailed when he is describing the major theories of aging--error accumulation and programmed death. Generally, he succeeds in clarifying technical concepts for the non-technical reader. The book is liberally seasoned with historical vignettes, analogies and diagrams. "Clock" clarifies various definitions of aging, different philosophies of aging and various theories of the biochemistry of aging. At the same time we are introduced to such diverse people as Casanova, Billy the Kid, Isadora Duncan, Alfred Nobel and Florence Nightingale. The vignettes of these people often liven up the book, but at times the analogies made from person to concept are a bit of a stretch. Medina serves as a tour guide of the aging body with stops at the skin and hair; the bones, the muscles and joints; the brain; the heart; the lungs; the digestive system; the senses; and the sexual anatomy and physiology. "Clock" is mostly a story of decline and fall of the human body with predictions about future high-tech genetic and hormonal antidotes. The third part of the sub-title 'Winding Back the Clock' only consumes 17 of 316 pages which is not in balance with the other two parts. Medina acknowledges but underplays the role of diet and exercise in winding back the clock. And although Dr. Medina recognizes the wide variability in the way people age as well as the variability of aging within individual body systems, he does not fully recognize the affects of culture and attitude on the aging process, but coming from a biologist this is to be expected. Overall, "Clock" is engaging and thought-provoking. I would, however, recommend several other books to give other views on aging other than the biological--try Betty Friedan's "Fountain of Age," Deepak Chopra's "Ageless Body, Timeless Mind" or Delany, Delany & Hearth's "Having Our Say: The Delany Sisters' First 100 Years."
The Clock of Ages: Why We Age - How We Age - Winding Back the Clock.: An article from: American Scientist
Average customer rating: Not rated
    The Clock of Ages: Why We Age - How We Age - Winding Back the Clock.: An article from: American Scientist

    Manufacturer: Sigma Xi, The Scientific Research Society
    ProductGroup: Book
    Binding: Digital

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    ASIN: B00097KP7C
    Release Date: 2005-07-28

    Aliphatic & Related Natural Product Chemistry
    Average customer rating: Not rated
      Aliphatic & Related Natural Product Chemistry
      Royal Society Of Chemistry
      Manufacturer: Science and Behavior Books
      ProductGroup: Book
      Binding: Hardcover

      OrganicOrganic | Chemistry | Professional Science | Professional & Technical | Subjects | Books
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      ASIN: 0851866425
      Aliphatic and Related Natural Product Chemistry Volume 1
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        Aliphatic and Related Natural Product Chemistry Volume 1

        Manufacturer: The Chemical Society
        ProductGroup: Book
        Binding: Hardcover
        ASIN: B000HNFZGY
        Aliphatic and Related Natural Product Chemistry Volume 2
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          Aliphatic and Related Natural Product Chemistry Volume 2

          Manufacturer: C R C Press LLC
          ProductGroup: Book
          Binding: Hardcover
          ASIN: B000HNBHL6
          Aliphatic and Related Natural Product Chemistry Volume 3
          Average customer rating: Not rated
            Aliphatic and Related Natural Product Chemistry Volume 3

            Manufacturer: Royal Society of Chemistry
            ProductGroup: Book
            Binding: Hardcover
            ASIN: B000HNDZTS

            Fuzzy Cluster Analysis: Methods for Classification, Data Analysis and Image Recognition
            Average customer rating: 2 out of 5 stars
            • Excellent advanced book in fuzzy cluster analysis
            • Worst book I have ever read
            • Too many unnecessary definitions
            Fuzzy Cluster Analysis: Methods for Classification, Data Analysis and Image Recognition
            Frank Höppner , Rudolf Kruse , Frank Klawonn , and Thomas Runkler
            Manufacturer: Wiley
            ProductGroup: Book
            Binding: Hardcover

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            ASIN: 0471988642

            Book Description

            Provides a timely and important introduction to fuzzy cluster analysis, its methods and areas of application, systematically describing different fuzzy clustering techniques so the user may choose methods appropriate for his problem. It provides a very thorough overview of the subject and covers classification, image recognition, data analysis and rule generation. The application examples are highly relevant and illustrative, and the use of the techniques are justified and well thought-out.

            Features include:

            * Sections on inducing fuzzy if-then rules by fuzzy clustering and non-alternating optimization fuzzy clustering algorithms

            * Discussion of solid fuzzy clustering techniques like the fuzzy c-means, the Gustafson-Kessel and the Gath-and-Geva algorithm for classification problems

            * Focus on linear and shell clustering techniques used for detecting contours in image analysis

            * Accompanying software and data sets pertaining to the examples presented, enabling the reader to learn through experimentation

            * Examination of the difficulties involved in evaluating the results of fuzzy cluster analysis and of determining the number of clusters with analysis of global and local validity measures

            This is one of the most comprehensive books on fuzzy clustering and will be welcomed by computer scientists, engineers and mathematicians in industry and research who are concerned with different methods, data analysis, pattern recognition or image processing. It will also give graduate students in computer science, mathematics or statistics a valuable overview.

            Customer Reviews:

            4 out of 5 stars Excellent advanced book in fuzzy cluster analysis.......2004-05-11

            Previous reviews are correct, this is not a book for beginners. This is an advanced text for specialists in the area of fuzzy clustering, and as such it is an excellent work. Standard fuzzy c-means, Gustafson-Kessel c-means and Gath-Geva c-means are drawn together in a single modeling framework for near-arbitrary cluster shapes. The cluster validity problem is examined in depth, and experimental results in image analysis are used to illustrate the theoretical material. An excellent monograph.

            1 out of 5 stars Worst book I have ever read.......2004-03-24

            This book is ridiculous. It has too many unnecessary and, even worse, unclear definitions. It never gives us the meanings of the strange symbols in those absurd definitions. If you want to understand fuzzy cluster analysis in a relatively short time and do not want to suffer, please do not buy this book.

            1 out of 5 stars Too many unnecessary definitions.......2004-03-24

            This is not a good book for people who want to understand the basic idea of fuzzy cluster analysis in a short time.
            Computer-Assisted Reasoning in Cluster Analysis
            Average customer rating: Not rated
              Computer-Assisted Reasoning in Cluster Analysis
              E. Backer
              Manufacturer: Prentice Hall PTR
              ProductGroup: Book
              Binding: Textbook Binding

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              ASIN: 0133418847
              Data Engineering: Fuzzy Mathematics in Systems Theory and Data Analysis
              Average customer rating: Not rated
                Data Engineering: Fuzzy Mathematics in Systems Theory and Data Analysis
                Olaf Wolkenhauer
                Manufacturer: Wiley-Interscience
                ProductGroup: Book
                Binding: Hardcover

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                ASIN: 0471416568

                Book Description

                Although data engineering is a multi-disciplinary field with applications in control, decision theory, and the emerging hot area of bioinformatics, there are no books on the market that make the subject accessible to non-experts. This book fills the gap in the field, offering a clear, user-friendly introduction to the main theoretical and practical tools for analyzing complex systems. An ftp site features the corresponding MATLAB and Mathematical tools and simulations.
                Market: Researchers in data management, electrical engineering, computer science, and life sciences.
                Fuzzy Neural Intelligent Systems: Mathematical Foundation and the Applications in Engineering
                Average customer rating: Not rated
                  Fuzzy Neural Intelligent Systems: Mathematical Foundation and the Applications in Engineering
                  Hongxing Li , C.L. Philip Chen , and Han-Pang Huang
                  Manufacturer: CRC
                  ProductGroup: Book
                  Binding: Hardcover

                  Fuzzy LogicFuzzy Logic | Algorithms | Programming | Computers & Internet | Subjects | Books
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                  ASIN: 0849323606

                  Book Description

                  Although fuzzy systems and neural networks are central to the field of soft computing, most research work has focused on the development of the theories, algorithms, and designs of systems for specific applications. There has been little theoretical support for fuzzy neural systems, especially their mathematical foundations. Fuzzy Neural Intelligent Systems fills this gap. It develops a mathematical basis for fuzzy neural networks, offers a better way of combining fuzzy logic systems with neural networks, and explores some of their engineering applications. Dividing their focus into three main areas of interest, the authors give a systematic, comprehensive treatment of the relevant concepts and modern practical applications: · Fundamental concepts and theories for fuzzy systems and neural networks. · Foundation for fuzzy neural networks and important related topics · Case examples for neuro-fuzzy systems, fuzzy systems, neural network systems, and fuzzy-neural systems Suitable for self-study, as a reference, and ideal as a textbook, Fuzzy Neural Intelligent Systems is accessible to students with a basic background in linear algebra and engineering mathematics. Mastering the material in this textbook will prepare students to better understand, design, and implement fuzzy neural systems, develop new applications, and further advance the field.

                  Modeling Techniques for Uncertain Systems: Proceedings of a Conference held in Sopron, Hungary, July 1992 (Progress in Systems and Control Theory)
                  Average customer rating: Not rated
                    Modeling Techniques for Uncertain Systems: Proceedings of a Conference held in Sopron, Hungary, July 1992 (Progress in Systems and Control Theory)

                    Manufacturer: Birkhäuser Boston
                    ProductGroup: Book
                    Binding: Hardcover

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                    ASIN: 081763746X
                    Possibility Theory With Applications to Data Analysis (UMIST Control Systems Centre Series, 5)
                    Average customer rating: Not rated
                      Possibility Theory With Applications to Data Analysis (UMIST Control Systems Centre Series, 5)
                      Olaf Wolkenhauer , and O. Wolkenhauer
                      Manufacturer: Research Studies Pr
                      ProductGroup: Book
                      Binding: Hardcover

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                      ASIN: 0471981613

                      Sunrise with Seamonsters
                      Average customer rating: 4.5 out of 5 stars
                      • Magazine writing
                      • essay writing at its best
                      • A quirky, evocative collection.
                      Sunrise with Seamonsters
                      Rh Value Publishing
                      Manufacturer: Random House Value Publishing
                      ProductGroup: Book
                      Binding: Hardcover

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                      5. Riding the Iron Rooster Riding the Iron Rooster

                      ASIN: 0517661616
                      Release Date: 1987-11-25

                      Book Description

                      The journeys of Paul Theroux take place not only in exotic, unexpected places of the world but in the thoughts, reading, and emotions of the writer himself. A gathering of people, places, and ideas in fifty glittering pieces of gold.

                      Customer Reviews:

                      3 out of 5 stars Magazine writing.......2007-01-15

                      This is a collection of 50-some articles Theroux sold to magazines over the years to finance his book-writing. His parents had seven children - considering how talented Paul and Alexander Theroux are, and that their brother Peter is a translator from the Arabic, I wonder what the rest of their siblings grew up to be. When in his article on the subways of New York for the New York Times magazine Paul Theroux quoted the graffito, "Guzmán - Ladrón, Maricón y Asesino" (Guzmán is a thief, a homosexual and a murderer), the editors cut out the word "Maricón" despite it being a part of the quotation: we do not allow such words to appear in our paper.

                      5 out of 5 stars essay writing at its best.......2000-07-06

                      This is a wonderful collection for fans of Theroux and writers who want to study the craft of essay writing. The range of topics is wide, covering everything from travel (of course) to politics (Nixon) to Tarzan-as-expatriate. It's also a great window into Theroux's development as a writer as it spans two and a half decades of his career.

                      I had the pleasure of reading these when I was in the Peace Corps myself, stationed in the Nepal highlands. Thanks for the fun and inspiration, Paul!

                      5 out of 5 stars A quirky, evocative collection........1999-12-06

                      Even without taking my copy of this down from the shelf, a mental vision of the cover conjures up brief mnemonic wisps of mental perfume: sailing on Cape Cod, his memories of Africa, the tale of the unironed shirt and the burrowing mites, the essay on extended family that has always made me wistful for the experience or at least envious to have a doctor and lawyer available for free consultations. Influential stuff from a more or less acerbic personality.
                      SUNRISE WITH SEAMONSTER
                      Average customer rating: Not rated
                        SUNRISE WITH SEAMONSTER
                        Neil Jordan
                        Manufacturer: Chatto & Windus
                        ProductGroup: Book
                        Binding: Hardcover
                        ASIN: B000K5O0SI
                        Sunrise with Seamonsters
                        Average customer rating: Not rated
                          Sunrise with Seamonsters
                          Paul Theroux
                          Manufacturer: Houghton, Mifflin and Co
                          ProductGroup: Book
                          Binding: Paperback
                          ASIN: B000FMDIM0
                          Sunrise with Seamonsters
                          Average customer rating: Not rated
                            Sunrise with Seamonsters
                            Paul THEROUX
                            Manufacturer: see notes for publisher info
                            ProductGroup: Book
                            Binding: Hardcover

                            TravelTravel | Writing | Reference | Subjects | Books
                            ASIN: 0241115434
                            Sunrise With Seamonsters  Travels & Discoveries 1964-1984
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                              Sunrise With Seamonsters Travels & Discoveries 1964-1984
                              Paul Theroux
                              Manufacturer: Houghton Mifflin Co.
                              ProductGroup: Book
                              Binding: Hardcover
                              ASIN: B000HZ6426
                              Sunrise With Seamonsters 1ST Edition
                              Average customer rating: Not rated
                                Sunrise With Seamonsters 1ST Edition
                                Paul Theroux
                                Manufacturer: HOUGHTON MIFFLIN CO@
                                ProductGroup: Book
                                Binding: Hardcover
                                ASIN: B000PZP2CQ
                                SUNRISE WITH SEAMONSTERS Travels and Discoveries
                                Average customer rating: Not rated
                                  SUNRISE WITH SEAMONSTERS Travels and Discoveries

                                  Manufacturer: Houghton Mifflin Company
                                  ProductGroup: Book
                                  Binding: Hardcover
                                  ASIN: B000HZICVC
                                  Sunrise With Seamonsters: Essays and Pieces
                                  Average customer rating: Not rated
                                    Sunrise With Seamonsters: Essays and Pieces
                                    Paul Theroux
                                    Manufacturer: Recorded Books
                                    ProductGroup: Book
                                    Binding: Audio Cassette

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                                    ASIN: 9999880436
                                    Sunrise with Seamonsters: Travels & Discoveries
                                    Average customer rating: Not rated
                                      Sunrise with Seamonsters: Travels & Discoveries

                                      Manufacturer: Houghton Mifflin
                                      ProductGroup: Book
                                      Binding: Hardcover
                                      ASIN: B000FLPEPK
                                      SUNRISE WITH SEAMONSTER
                                      Average customer rating: Not rated
                                        SUNRISE WITH SEAMONSTER
                                        Neil Jordan
                                        Manufacturer: Chatto & Windus
                                        ProductGroup: Book
                                        Binding: Hardcover
                                        ASIN: B000K5Q1F8

                                        Books:

                                        1. The Philosopher Fish: Sturgeon, Caviar, and the Geography of Desire
                                        2. The Pneumococcus
                                        3. The Stuff of Life: Profiles of the Molecules That Make Us Tick
                                        4. The Vascular Smooth Muscle Cell: Molecular and Biological Responses to the Extracellular Matrix (Biology of Extracellular Matrix)
                                        5. Theoretical Ecosystem Ecology: Understanding Element Cycles
                                        6. Transmission Electron Energy Loss Spectrometry in Materials Science and the EELS Atlas
                                        7. Tropical Fruits and Frugivores: The Search for Strong Interactors
                                        8. Video Microscopy : The Fundamentals (The Language of Science)
                                        9. Why Elephants Have Big Ears: Understanding Patterns of Life on Earth
                                        10. Yeast Physiology and Biotechnology

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